标题
Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models
作者
关键词
Anticonvulsants, Clonic seizures, Epilepsy, Immunofluorescence, Microglial cells, Tonic-clonic seizures, Blood plasma, Astrocytes
出版物
PLoS One
Volume 11, Issue 6, Pages e0156468
出版商
Public Library of Science (PLoS)
发表日期
2016-06-10
DOI
10.1371/journal.pone.0156468
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy
- (2016) Halima Amhaoul et al. NEUROPHARMACOLOGY
- Astrocyte uncoupling as a cause of human temporal lobe epilepsy
- (2015) Peter Bedner et al. BRAIN
- P2X Receptors and Inflammation
- (2015) Francesco Virgilio CURRENT MEDICINAL CHEMISTRY
- Up-regulation of P2X7 receptor-mediated inhibition of GABA uptake by nerve terminals of the human epileptic neocortex
- (2015) Aurora R. Barros-Barbosa et al. EPILEPSIA
- Effect of GLT-1 modulator and P2X7 antagonists alone and in combination in the kindling model of epilepsy in rats
- (2015) Neha Soni et al. EPILEPSY & BEHAVIOR
- A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334
- (2015) Brian Lord et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis?
- (2015) Annamaria Vezzani Expert Opinion On Drug Safety
- Reactive Astrogliosis Causes the Development of Spontaneous Seizures
- (2015) S. Robel et al. JOURNAL OF NEUROSCIENCE
- Epilepsy: new advances
- (2015) Solomon L Moshé et al. LANCET
- GABA A currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis
- (2015) Cristina Roseti et al. NEUROBIOLOGY OF DISEASE
- IL-1β, IL-6 and IL1Ra levels in temporal lobe epilepsy
- (2015) Irem Fatma Uludag et al. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
- Can pentylenetetrazole and maximal electroshock rodent seizure models quantitatively predict antiepileptic efficacy in humans?
- (2015) Eunice S.M. Yuen et al. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
- The CA3 region of the hippocampus: how is it? What is it for? How does it do it?
- (2015) Enrico Cherubini et al. Frontiers in Cellular Neuroscience
- Microglia in action: how aging and injury can change the brain’s guardians
- (2015) Athanasios Lourbopoulos et al. Frontiers in Cellular Neuroscience
- ATP as a multi-target danger signal in the brain
- (2015) Ricardo J. Rodrigues et al. Frontiers in Neuroscience
- P2X7 Receptor Inhibition Interrupts the Progression of Seizures in Immature Rats and Reduces Hippocampal Damage
- (2014) Guillaume Mesuret et al. CNS Neuroscience & Therapeutics
- Commentary: Epilepsy is a Global Problem
- (2014) Emilio Perucca et al. EPILEPSIA
- The Potential of Antiseizure Drugs and Agents that Act on Novel Molecular Targets as Antiepileptogenic Treatments
- (2014) Rafal M. Kaminski et al. Neurotherapeutics
- P2X7 receptor: an emerging target in central nervous system diseases
- (2014) Beáta Sperlágh et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Neuronal mechanisms of epileptogenesis
- (2014) Roberto Di Maio Frontiers in Cellular Neuroscience
- Epilepsy and Inflammation in the Brain: Overview and Pathophysiology
- (2014) Annamaria Vezzani Epilepsy Currents
- Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567
- (2013) Anindya Bhattacharya et al. BRITISH JOURNAL OF PHARMACOLOGY
- Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079
- (2013) Alba Jimenez-Pacheco et al. EPILEPSIA
- New avenues for anti-epileptic drug discovery and development
- (2013) Wolfgang Löscher et al. NATURE REVIEWS DRUG DISCOVERY
- Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy
- (2013) F.M. Noe et al. NEUROBIOLOGY OF DISEASE
- Natural compounds with P2X7 receptor-modulating properties
- (2013) Wolfgang Fischer et al. Purinergic Signalling
- Microglia: Scapegoat, Saboteur, or Something Else?
- (2013) A. Aguzzi et al. SCIENCE
- P2X receptors as targets for the treatment of status epilepticus
- (2013) David C. Henshall et al. Frontiers in Cellular Neuroscience
- Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists
- (2013) Michael A. Letavic et al. ACS Medicinal Chemistry Letters
- Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms
- (2013) Lin-Hua Jiang et al. Frontiers in Pharmacology
- Neurological Diseases as Primary Gliopathies: A Reassessment of Neurocentrism
- (2012) Alexei Verkhratsky et al. ASN Neuro
- P2X7 Receptors: Channels, Pores and More
- (2012) C. Volonte et al. CNS & Neurological Disorders-Drug Targets
- Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects
- (2012) Eva M Jimenez-Mateos et al. NATURE MEDICINE
- Tanshinone IIA Attenuates the Inflammatory Response and Apoptosis after Traumatic Injury of the Spinal Cord in Adult Rats
- (2012) Xin Yin et al. PLoS One
- Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice
- (2012) Donald E. Kimbler et al. PLoS One
- Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma
- (2011) Wolfgang Löscher et al. EPILEPSIA
- Inflammation in epilepsy: Clinical observations
- (2011) Eleonora Aronica et al. EPILEPSIA
- Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice
- (2011) Tobias Engel et al. FASEB JOURNAL
- The P2X7 receptor–pannexin-1 complex decreases muscarinic acetylcholine receptor–mediated seizure susceptibility in mice
- (2011) Ji-Eun Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1
- (2011) M. Maroso et al. JOURNAL OF INTERNAL MEDICINE
- P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia
- (2011) Joana Arbeloa et al. NEUROBIOLOGY OF DISEASE
- The roles of P2X7 receptor in regional-specific microglial responses in the rat brain following status epilepticus
- (2011) Hea Kyung Choi et al. NEUROLOGICAL SCIENCES
- Inflammation and prevention of epileptogenesis
- (2011) Teresa Ravizza et al. NEUROSCIENCE LETTERS
- Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice
- (2011) Mattia Maroso et al. Neurotherapeutics
- Activation and Regulation of Purinergic P2X Receptor Channels
- (2011) C. Coddou et al. PHARMACOLOGICAL REVIEWS
- Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
- (2011) Wolfgang Löscher SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
- Inflammation in Neurological Disorders: A Help or a Hindrance?
- (2010) V. Wee Yong NEUROSCIENTIST
- Astrocytes: biology and pathology
- (2009) Michael V. Sofroniew et al. ACTA NEUROPATHOLOGICA
- Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a ‘two-hit’ seizure model
- (2009) Kathleen C. Somera-Molina et al. BRAIN RESEARCH
- The P2X7 purinergic receptor: from physiology to neurological disorders
- (2009) Stephen D. Skaper et al. FASEB JOURNAL
- Blockade of P2X receptor prevents astroglial death in the dentate gyrus following pilocarpine-induced status epilepticus
- (2009) Ji-Eun Kim et al. NEUROLOGICAL RESEARCH
- Heterogeneity of microglia and TNF signaling as determinants for neuronal death or survival
- (2009) Andrew D. Kraft et al. NEUROTOXICOLOGY
- The P2X7 receptor–pannexin connection to dye uptake and IL-1β release
- (2009) Pablo Pelegrin et al. Purinergic Signalling
- Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice
- (2008) Genshin Mouri et al. BRAIN RESEARCH
- Research priorities in epilepsy for the next decade-A representative view of the European scientific community: Summary of the ILAE Epilepsy Research Workshop, Brussels, 17-18 January 2008
- (2008) Michel Baulac et al. EPILEPSIA
- Alteration of purinergic P2X4 and P2X7 receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine
- (2008) Flavia Doná et al. EPILEPSY RESEARCH
- The P2X7receptor as a therapeutic target
- (2008) Romeo Romagnoli et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Status Epilepticus Induces a Particular Microglial Activation State Characterized by Enhanced Purinergic Signaling
- (2008) E. Avignone et al. JOURNAL OF NEUROSCIENCE
- Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimerʼs disease
- (2008) Jae K. Ryu et al. NEUROREPORT
- Role of Brain Inflammation in Epileptogenesis
- (2008) Jieun Choi et al. YONSEI MEDICAL JOURNAL
- Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy
- (2007) Teresa Ravizza et al. NEUROBIOLOGY OF DISEASE
- Synaptic terminals from mice midbrain exhibit functional P2X7 receptor
- (2007) P. Marín-García et al. NEUROSCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search