Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079

CHOP regulates the p53–MDM2 axis and is required for neuronal survival after seizures

(2013) Tobias Engel et al.   BRAIN

The Specificity Protein Factor Sp1 Mediates Transcriptional Regulation of P2X7 Receptors in the Nervous System

(2012) Paula García-Huerta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

(2012) Eva M Jimenez-Mateos et al.   NATURE MEDICINE

Reduced Mature MicroRNA Levels in Association with Dicer Loss in Human Temporal Lobe Epilepsy with Hippocampal Sclerosis

(2012) Ross C. McKiernan et al.   PLoS One

Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice

(2012) Donald E. Kimbler et al.   PLoS One

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

(2011) Tobias Engel et al.   FASEB JOURNAL

The P2X7 receptor–pannexin-1 complex decreases muscarinic acetylcholine receptor–mediated seizure susceptibility in mice

(2011) Ji-Eun Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases

(2011) Juan Ignacio Diaz-Hernandez et al.   NEUROBIOLOGY OF AGING

P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia

(2011) Joana Arbeloa et al.   NEUROBIOLOGY OF DISEASE

BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor

(2010) Tobias Engel et al.   JOURNAL OF NEUROCHEMISTRY

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Cortical thickness analysis in temporal lobe epilepsy: Reproducibility and relation to outcome

(2010) B. C. Bernhardt et al.   NEUROLOGY

Release of Adenosine and ATP During Ischemia and Epilepsy

(2009) Nicholas Dale et al.   Current Neuropharmacology

Altered P2X7-receptor level and function in mouse models of Huntington’s disease and therapeutic efficacy of antagonist administration

(2009) Miguel Díaz-Hernández et al.   FASEB JOURNAL

Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma

(2009) Tobias Engel et al.   FASEB JOURNAL

Hippocampal injury, atrophy, synaptic reorganization, and epileptogenesis after perforant pathway stimulation-induced status epilepticus in the mouse

(2009) Friederike Kienzler et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Signaling at Purinergic P2X Receptors

(2008) Annmarie Surprenant et al.   Annual Review of Physiology

Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice

(2008) Genshin Mouri et al.   BRAIN RESEARCH

Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs

(2008) Claude G. Wasterlain et al.   EPILEPSIA

Status Epilepticus Induces a Particular Microglial Activation State Characterized by Enhanced Purinergic Signaling

(2008) E. Avignone et al.   JOURNAL OF NEUROSCIENCE

The pilocarpine model of temporal lobe epilepsy

(2008) Giulia Curia et al.   JOURNAL OF NEUROSCIENCE METHODS

Purinergic signalling in the nervous system: an overview

(2008) Maria P. Abbracchio et al.   TRENDS IN NEUROSCIENCES