Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

The P2X7 receptor–pannexin-1 complex decreases muscarinic acetylcholine receptor–mediated seizure susceptibility in mice

(2011) Ji-Eun Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue-nonspecific alkaline phosphatase promotes axonal growth of hippocampal neurons

(2011) M. Díez-Zaera et al.   MOLECULAR BIOLOGY OF THE CELL

Activation and Regulation of Purinergic P2X Receptor Channels

(2011) C. Coddou et al.   PHARMACOLOGICAL REVIEWS

Microglia: Proliferation and activation driven by the P2X7 receptor

(2010) Mastura Monif et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

P2X7 receptors enhance glutamate release in hippocampal hilar neurons

(2010) Jin-Hwa Cho et al.   NEUROREPORT

Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus

(2009) B M Murphy et al.   CELL DEATH AND DIFFERENTIATION

Molecular basis of self-sustaining seizures and pharmacoresistance during status epilepticus: The receptor trafficking hypothesis revisited

(2009) Claude G. Wasterlain et al.   EPILEPSIA

Altered P2X7-receptor level and function in mouse models of Huntington’s disease and therapeutic efficacy of antagonist administration

(2009) Miguel Díaz-Hernández et al.   FASEB JOURNAL

Ca2+/calmodulin-dependent kinase II signalling cascade mediates P2X7 receptor-dependent inhibition of neuritogenesis in neuroblastoma cells

(2009) Rosa Gómez-Villafuertes et al.   FEBS Journal

A Functional P2X7 Splice Variant with an Alternative Transmembrane Domain 1 Escapes Gene Inactivation in P2X7 Knock-out Mice

(2009) Annette Nicke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peripheral origin of IL-1β production in the rodent hippocampus under in vivo systemic bacterial lipopolysaccharide (LPS) challenge and its regulation by P2X7 receptors

(2009) C. Csölle et al.   JOURNAL OF NEUROIMMUNOLOGY

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Impaired Interleukin-1β and c-Fos Expression in the Hippocampus Is Associated with a Spatial Memory Deficit in P2X7 Receptor-Deficient Mice

(2009) Virginie F. Labrousse et al.   PLoS One

P2X7 receptor-Pannexin1 complex: pharmacology and signaling

(2008) R. Iglesias et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ketamine and Neurotoxicity: Clinical Perspectives and Implications for Emergency Medicine

(2008) Steven M. Green et al.   ANNALS OF EMERGENCY MEDICINE

Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs

(2008) Claude G. Wasterlain et al.   EPILEPSIA

Alteration of purinergic P2X4 and P2X7 receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine

(2008) Flavia Doná et al.   EPILEPSY RESEARCH

Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7receptor-mediated IL-1β release

(2008) Liliana Bernardino et al.   JOURNAL OF NEUROCHEMISTRY

Status Epilepticus Induces a Particular Microglial Activation State Characterized by Enhanced Purinergic Signaling

(2008) E. Avignone et al.   JOURNAL OF NEUROSCIENCE

Purinergic signalling and disorders of the central nervous system

(2008) Geoffrey Burnstock   NATURE REVIEWS DRUG DISCOVERY

Antagonism of peripheral inflammation reduces the severity of status epilepticus

(2008) Nicola Marchi et al.   NEUROBIOLOGY OF DISEASE

Activation of Pannexin-1 Hemichannels Augments Aberrant Bursting in the Hippocampus

(2008) R. J. Thompson et al.   SCIENCE