Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma

Efficacy of New Antiepileptic Drugs

(2011) Dieter Schmidt   Epilepsy Currents

Non-interventional surveillance study of adverse events in patients with epilepsy

(2010) J. A. Cramer et al.   ACTA NEUROLOGICA SCANDINAVICA

Developmental and epilepsy outcomes at age 4 years in the UKISS trial comparing hormonal treatments to vigabatrin for infantile spasms: a multi-centre randomised trial

(2010) K. Darke et al.   ARCHIVES OF DISEASE IN CHILDHOOD

A Pooled Analysis of Lacosamide Clinical Trial Data Grouped by Mechanism of Action of Concomitant Antiepileptic Drugs

(2010) John-Kenneth Sake et al.   CNS DRUGS

Posttraumatic epilepsy

(2010) Irina Kharatishvili et al.   CURRENT OPINION IN NEUROLOGY

Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: A randomized double-blind clinical trial

(2010) Eugene Ramsay et al.   EPILEPSIA

Lacosamide as adjunctive therapy for partial-onset seizures: A randomized controlled trial

(2010) Steve Chung et al.   EPILEPSIA

When clinical trials make history: Demonstrating efficacy of new antiepileptic drugs as monotherapy

(2010) Emilio Perucca   EPILEPSIA

Therapeutic approaches to epileptogenesis-Hope on the horizon

(2010) Asla Pitkänen   EPILEPSIA

Historical control monotherapy design in the treatment of epilepsy

(2010) Jacqueline A. French et al.   EPILEPSIA

Functional, metabolic, and synaptic changes after seizures as potential targets for antiepileptic therapy

(2010) Wolfgang Löscher et al.   EPILEPSY & BEHAVIOR

A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures

(2010) Michel Baulac et al.   EPILEPSY RESEARCH

Invited Article: Comparative effectiveness research, evidence-based medicine, and the AAN

(2010) J. A. French et al.   NEUROLOGY

Use of antiepileptic drugs in epilepsy and the risk of self-harm or suicidal behavior

(2010) F. Andersohn et al.   NEUROLOGY

Suicide-Related Events in Patients Treated with Antiepileptic Drugs

(2010) Alejandro Arana et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ethosuximide, Valproic Acid, and Lamotrigine in Childhood Absence Epilepsy

(2010) Tracy A. Glauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research

(2010) W. Loscher et al.   PHARMACOLOGICAL REVIEWS

What Is an Epileptic Seizure? Unifying Definitions in Clinical Practice and Animal Research to Develop Novel Treatments

(2010) Raimondo D’Ambrosio et al.   Epilepsy Currents

Levetiracetam for managing neurologic and psychiatric disorders

(2009) M. U. Farooq et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Early seizure frequency and aetiology predict long-term medical outcome in childhood-onset epilepsy

(2009) M. Sillanpaa et al.   BRAIN

Refractory Gastro-Oesophageal Reflux Disease

(2009) Julia J. Liu et al.   DRUGS

Drug treatment of epilepsy in the century of the ILAE: The first 50 years, 1909-1958

(2009) Simon D. Shorvon   EPILEPSIA

Posttraumatic epilepsy: The challenge of translating discoveries in the laboratory to pathways to a cure

(2009) Marc A. Dichter   EPILEPSIA

Vigabatrin: 2008 Update

(2009) L. James Willmore et al.   EPILEPSIA

Preventing and treating posttraumatic seizures: The human experience

(2009) Nancy R. Temkin   EPILEPSIA

Drug treatment of epilepsy in the century of the ILAE: The second 50 years, 1959-2009

(2009) Simon D. Shorvon   EPILEPSIA

Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: Systematic review and meta-analysis

(2009) Stefan Beyenburg et al.   EPILEPSIA

Drug treatment of epilepsy: Options and limitations

(2009) Dieter Schmidt   EPILEPSY & BEHAVIOR

Preclinical assessment of proconvulsant drug activity and its relevance for predicting adverse events in humans

(2009) Wolfgang Löscher   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacodynamic interactions between antiepileptic drugs: preclinical data based on isobolography

(2009) Stanislaw J Czuczwar et al.   Expert Opinion on Drug Metabolism & Toxicology

The Little Compound That Could: How Phenytoin Changed Drug Discovery and Development

(2009) R. J. Anderson   MOLECULAR INTERVENTIONS

Key factors in the discovery and development of new antiepileptic drugs

(2009) Meir Bialer et al.   NATURE REVIEWS DRUG DISCOVERY

Epileptogenesis in the immature brain: emerging mechanisms

(2009) Sanjay N. Rakhade et al.   Nature Reviews Neurology

Teratogenic Effects of Antiepileptic Medications

(2009) Torbjörn Tomson et al.   NEUROLOGIC CLINICS

Levetiracetam in spinal cord injury pain: a randomized controlled trial

(2009) N B Finnerup et al.   SPINAL CORD

New Developments in Antiepileptic Drug Resistance: An Integrative View

(2009) Dieter Schmidt et al.   Epilepsy Currents

Designing Clinical Trials to Assess Antiepileptic Drugs as Monotherapy

(2008) Emilio Perucca   CNS DRUGS

New molecular targets for antiepileptic drugs: α2δ, SV2A, and Kv7/KCNQ/M potassium channels

(2008) Michael A. Rogawski et al.   Current Neurology and Neuroscience Reports

Modern management of epilepsy: A practical approach

(2008) Christian E. Elger et al.   EPILEPSY & BEHAVIOR

Progress report on new antiepileptic drugs: A summary of the Ninth Eilat Conference (EILAT IX)

(2008) Meir Bialer et al.   EPILEPSY RESEARCH

Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome

(2008) T. Glauser et al.   NEUROLOGY

Intrinsic Severity as a Determinant of Antiepileptic Drug Refractoriness

(2008) Michael A. Rogawski et al.   Epilepsy Currents