P2X7 Receptor Inhibition Interrupts the Progression of Seizures in Immature Rats and Reduces Hippocampal Damage

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567

(2013) Anindya Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079

(2013) Alba Jimenez-Pacheco et al.   EPILEPSIA

Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures

(2013) Ryan T. Cleary et al.   PLoS One

Newly emerging therapies for neonatal seizures

(2013) Ronit M. Pressler et al.   Seminars in Fetal & Neonatal Medicine

Treatment of neonatal seizures

(2013) Linda G.M. van Rooij et al.   Seminars in Fetal & Neonatal Medicine

P2X receptors as targets for the treatment of status epilepticus

(2013) David C. Henshall et al.   Frontiers in Cellular Neuroscience

Identification of new epilepsy treatments: Issues in preclinical methodology

(2012) Aristea S. Galanopoulou et al.   EPILEPSIA

Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette

(2012) Kevin E. Chapman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

ATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation

(2012) Jian Zou et al.   GLIA

Neuropathological Sequelae of Developmental Exposure to Antiepileptic and Anesthetic Drugs

(2012) Christopher Andreas Turski et al.   Frontiers in Neurology

Treatment of Pediatric Status Epilepticus

(2011) Tobias Loddenkemper et al.   Current Treatment Options in Neurology

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

(2011) Tobias Engel et al.   FASEB JOURNAL

The P2X7 receptor–pannexin-1 complex decreases muscarinic acetylcholine receptor–mediated seizure susceptibility in mice

(2011) Ji-Eun Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation and Regulation of Purinergic P2X Receptor Channels

(2011) C. Coddou et al.   PHARMACOLOGICAL REVIEWS

P2X7-Dependent Release of Interleukin-1  and Nociception in the Spinal Cord following Lipopolysaccharide

(2010) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

P2X7 receptors enhance glutamate release in hippocampal hilar neurons

(2010) Jin-Hwa Cho et al.   NEUROREPORT

Neonatal Status Epilepticus

(2010) Russell Lawrence et al.   Seminars in Pediatric Neurology

Experimental Neonatal Status Epilepticus and the Development of Temporal Lobe Epilepsy with Unilateral Hippocampal Sclerosis

(2009) Mark Dunleavy et al.   AMERICAN JOURNAL OF PATHOLOGY

A KCNQ channel opener for experimental neonatal seizures and status epilepticus

(2009) YogendraSinh H. Raol et al.   ANNALS OF NEUROLOGY

Antiepileptic drugs and brain development

(2009) Chrysanthy Ikonomidou et al.   EPILEPSY RESEARCH

Altered P2X7-receptor level and function in mouse models of Huntington’s disease and therapeutic efficacy of antagonist administration

(2009) Miguel Díaz-Hernández et al.   FASEB JOURNAL

The P2X7 purinergic receptor: from physiology to neurological disorders

(2009) Stephen D. Skaper et al.   FASEB JOURNAL

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain Injury

(2009) Hannah C. Glass et al.   JOURNAL OF PEDIATRICS

Cellular localization of P2X7 receptor mRNA in the rat brain

(2008) Yong Yu et al.   BRAIN RESEARCH

Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7receptor-mediated IL-1β release

(2008) Liliana Bernardino et al.   JOURNAL OF NEUROCHEMISTRY

Treatment of community-onset, childhood convulsive status epilepticus: a prospective, population-based study

(2008) Richard FM Chin et al.   LANCET NEUROLOGY

Purinergic signalling and disorders of the central nervous system

(2008) Geoffrey Burnstock   NATURE REVIEWS DRUG DISCOVERY