Targeting mitochondrial alterations to prevent type 2 diabetes-Evidence from studies of dietary redox-active compounds

SIRT1 Activators: The Evidence STACks up

(2016) Sita Kugel et al.   Aging-US

Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat

(2013) S. Hicks et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resveratrol supplementation improves white adipose tissue function in a depot-specific manner in Zucker diabetic fatty rats

(2013) Marie-Soleil Beaudoin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits?

(2013) Silvie Timmers et al.   Annals of the New York Academy of Sciences

Resveratrol in metabolic health: an overview of the current evidence and perspectives

(2013) Morten Møller Poulsen et al.   Annals of the New York Academy of Sciences

What is new for resveratrol? Is a new set of recommendations necessary?

(2013) Ole Vang   Annals of the New York Academy of Sciences

Mitochondria and Metabolic Homeostasis

(2013) Zhiyong Cheng et al.   ANTIOXIDANTS & REDOX SIGNALING

Exploring the Promise of Resveratrol: Where Do We Go From Here?

(2013) J. P. Crandall et al.   DIABETES

Sirtuin 1-mediated Effects of Exercise and Resveratrol on Mitochondrial Biogenesis

(2013) Keir J. Menzies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate

(2013) Jiahui Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanisms of Resveratrol-Induced Inhibition of Clonal Expansion and Terminal Adipogenic Differentiation in 3T3-L1 Preadipocytes

(2013) Maria C. Mitterberger et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial

(2013) Martin de Bock et al.   PLoS One

Resveratrol Metabolites Modify Adipokine Expression and Secretion in 3T3-L1 Pre-Adipocytes and Mature Adipocytes

(2013) Itziar Eseberri et al.   PLoS One

Red Wine, Toast of the Town (Again)

(2013) H. Yuan et al.   SCIENCE

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation

(2013) Kazuhiko Higashida et al.   PLOS BIOLOGY

One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease

(2012) João Tomé-Carneiro et al.   AMERICAN JOURNAL OF CARDIOLOGY

Mitochondrial Morphology in Metabolic Diseases

(2012) Chad A. Galloway et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Fatty Acid Oxidation in Obesity

(2012) Dolors Serra et al.   ANTIOXIDANTS & REDOX SIGNALING

Early determinants of type-2 diabetes

(2012) L.M. Berends et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose tolerance in diabetic KK-Ay mice

(2012) Mayumi Takada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Grape Resveratrol Increases Serum Adiponectin and Downregulates Inflammatory Genes in Peripheral Blood Mononuclear Cells: A Triple-Blind, Placebo-Controlled, One-Year Clinical Trial in Patients with Stable Coronary Artery Disease

(2012) João Tomé-Carneiro et al.   CARDIOVASCULAR DRUGS AND THERAPY

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

(2012) Jun Yoshino et al.   Cell Metabolism

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle

(2012) Deborah M. Muoio et al.   Cell Metabolism

Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance

(2012) François R. Jornayvaz et al.   Cell Metabolism

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

High-Dose Resveratrol Supplementation in Obese Men: An Investigator-Initiated, Randomized, Placebo-Controlled Clinical Trial of Substrate Metabolism, Insulin Sensitivity, and Body Composition

(2012) M. M. Poulsen et al.   DIABETES

Adiponectin: mechanistic insights and clinical implications

(2012) A. T. Turer et al.   DIABETOLOGIA

Dietary polyphenols preconditioning protects 3T3-L1 preadipocytes from mitochondrial alterations induced by oxidative stress

(2012) Pascal Baret et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Analysis of Total Contents of Hydroxytyrosol and Tyrosol in Olive Oils

(2012) Concepción Romero et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pyrroloquinoline-quinone and its versatile roles in biological processes

(2012) H S Misra et al.   JOURNAL OF BIOSCIENCES

Physical Activity Is the Key Determinant of Skeletal Muscle Mitochondrial Function in Type 2 Diabetes

(2012) F. H. J. van Tienen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Occurrence and Bioactivity of Polyphenols in Tunisian Olive Products and by-Products: A Review

(2012) Amani Taamalli et al.   JOURNAL OF FOOD SCIENCE

Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance

(2012) Jill P. Crandall et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Prediabetes: a high-risk state for diabetes development

(2012) Adam G Tabák et al.   LANCET

Alperujo extract, hydroxytyrosol, and 3,4-dihydroxyphenylglycol are bioavailable and have antioxidant properties in vitamin E-deficient rats-a proteomics and network analysis approach

(2012) Guillermo Rodríguez-Gutiérrez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Delipidating effect of resveratrol metabolites in 3T3-L1 adipocytes

(2012) Arrate Lasa et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice

(2012) Antje Bruckbauer et al.   Nutrition & Metabolism

Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet

(2012) Morten Møller Poulsen et al.   NUTRITION RESEARCH

Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus

(2012) Jayesh Kumar Bhatt et al.   NUTRITION RESEARCH

The adipose organ: white-brown adipocyte plasticity and metabolic inflammation

(2012) A. Smorlesi et al.   Obesity Reviews

Mitochondrial dysfunction in white adipose tissue

(2012) Christine M. Kusminski et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Brown adipose tissue

(2012) Kristy Townsend et al.   Adipocyte

MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan

(2011) Ehab H. Sarsour et al.   AGE

Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle

(2011) Brendon J. Gurd et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Effect of resveratrol on fat mobilization

(2011) Clifton A. Baile et al.   Annals of the New York Academy of Sciences

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients

(2011) Pál Brasnyó et al.   BRITISH JOURNAL OF NUTRITION

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Hydroxytyrosol reduces intracellular reactive oxygen species levels in vascular endothelial cells by upregulating catalase expression through the AMPK–FOXO3a pathway

(2011) Houda Zrelli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: Regulatory effects of hydroxytyrosol

(2011) Zhihui Feng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Direct Liquid Chromatography Method for the Simultaneous Quantification of Hydroxytyrosol and Tyrosol in Red Wines

(2011) Zulema Piñeiro et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sirtuin 1 (SIRT1) Deacetylase Activity Is Not Required for Mitochondrial Biogenesis or Peroxisome Proliferator-activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation following Endurance Exercise

(2011) Andrew Philp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial dysfunction in patients with primary congenital insulin resistance

(2011) Alison Sleigh et al.   JOURNAL OF CLINICAL INVESTIGATION

Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression

(2011) Sifan Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: activation of Nrf2 and JNK-p62/SQSTM1 pathways

(2011) Xuan Zou et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

(2011) Julia Szendroedi et al.   Nature Reviews Endocrinology

Altering Pyrroloquinoline Quinone Nutritional Status Modulates Mitochondrial, Lipid, and Energy Metabolism in Rats

(2011) Kathryn Bauerly et al.   PLoS One

The neuroprotective action of pyrroloquinoline quinone against glutamate-induced apoptosis in hippocampal neurons is mediated through the activation of PI3K/Akt pathway

(2011) Qi Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Resveratrol modulates adipokine expression and improves insulin sensitivity in adipocytes: Relative to inhibition of inflammatory responses

(2010) Liu Kang et al.   BIOCHIMIE

Foxo1 in hepatic lipid metabolism

(2010) Zhiyong Cheng et al.   CELL CYCLE

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

The Role of Mitochondria in the Pathogenesis of Type 2 Diabetes

(2010) Mary-Elizabeth Patti et al.   ENDOCRINE REVIEWS

Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis

(2010) Isabelle Mader et al.   FASEB JOURNAL

Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants

(2010) J Ølholm et al.   INTERNATIONAL JOURNAL OF OBESITY

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic β-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats

(2010) P. Palsamy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Skeletal Muscle Mitochondria in Insulin Resistance: Differences in IntermyofibrillarVersusSubsarcolemmal Subpopulations and Relationship to Metabolic Flexibility

(2010) Peter Chomentowski et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells

(2010) Lu Zhu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol enhances fatty acid oxidation capacity and reduces resistin and Retinol-Binding Protein 4 expression in white adipocytes

(2010) Josep Mercader et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol and genistein as adenosine triphosphate–depleting agents in fat cells

(2010) Katarzyna Szkudelska et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hydroxytyrosol: from laboratory investigations to future clinical trials

(2010) Sergio Granados-Principal et al.   NUTRITION REVIEWS

Cytoprotective effects of olive mill wastewater extract and its main constituent hydroxytyrosol in PC12 cells

(2010) Sebastian Schaffer et al.   PHARMACOLOGICAL RESEARCH

Insulin signaling meets mitochondria in metabolism

(2010) Zhiyong Cheng et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

(2009) R. C.R. Meex et al.   DIABETES

AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

(2009) J.-H. Um et al.   DIABETES

Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1α Expression

(2009) Winyoo Chowanadisai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes

(2009) Jiejie Hao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Foxo1 integrates insulin signaling with mitochondrial function in the liver

(2009) Zhiyong Cheng et al.   NATURE MEDICINE

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Survey of thetrans-Resveratrol andtrans-Piceid Content of Cocoa-Containing and Chocolate Products

(2008) W. Jeffrey Hurst et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin

(2008) Jeong-Yeh Yang et al.   LIFE SCIENCES

Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes

(2008) Srujana Rayalam et al.   PHYTOTHERAPY RESEARCH

A Combination of Nutriments Improves Mitochondrial Biogenesis and Function in Skeletal Muscle of Type 2 Diabetic Goto–Kakizaki Rats

(2008) Weili Shen et al.   PLoS One