The role of mitochondria in insulin resistance and type 2 diabetes mellitus

Liver ATP Synthesis Is Lower and Relates to Insulin Sensitivity in Patients With Type 2 Diabetes

(2011) A. I. Schmid et al.   DIABETES CARE

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Acute elevation of plasma lipids does not affect ATP synthesis in human skeletal muscle

(2010) A. Brehm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

(2010) Craig C. Beeson et al.   ANALYTICAL BIOCHEMISTRY

Mitochondrial metabolic function assessed in vivo and in vitro

(2010) Ian R Lanza et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

(2010) N. Lefort et al.   DIABETES

Compensatory Increases in Nuclear PGC1  Protein Are Primarily Associated With Subsarcolemmal Mitochondrial Adaptations in ZDF Rats

(2010) G. P. Holloway et al.   DIABETES

Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling

(2010) L. D. Hoeg et al.   DIABETES

Body and Liver Fat Mass Rather Than Muscle Mitochondrial Function Determine Glucose Metabolism in Women With a History of Gestational Diabetes Mellitus

(2010) T. Prikoszovich et al.   DIABETES CARE

Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals

(2010) E. Phielix et al.   DIABETOLOGIA

The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin Resistance

(2010) Ines Pagel-Langenickel et al.   ENDOCRINE REVIEWS

Evidence for a Relationship between Body Mass and Energy Metabolism in the Human Brain

(2010) André Schmoller et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Skeletal Muscle Mitochondria in Insulin Resistance: Differences in IntermyofibrillarVersusSubsarcolemmal Subpopulations and Relationship to Metabolic Flexibility

(2010) Peter Chomentowski et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of18F-FDG-Detected BAT in Humans

(2010) Veronique Ouellet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired insulin stimulation of muscular ATP production in patients with type 1 diabetes

(2010) M. Kacerovsky et al.   JOURNAL OF INTERNAL MEDICINE

Diacylglycerol-mediated insulin resistance

(2010) Derek M Erion et al.   NATURE MEDICINE

Brown adipose tissue—a new role in humans?

(2010) Martin E. Lidell et al.   Nature Reviews Endocrinology

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Measuring the acute effect of insulin infusion on ATP turnover rate in human skeletal muscle using phosphorus-31 magnetic resonance saturation transfer spectroscopy

(2010) Ee Lin Lim et al.   NMR IN BIOMEDICINE

Increased Levels of Plasma Acylcarnitines in Obesity and Type 2 Diabetes and Identification of a Marker of Glucolipotoxicity

(2010) Stephanie J. Mihalik et al.   Obesity

Nonalcoholic Fatty Liver Disease: Detection of Elevated Nicotinamide Adenine Dinucleotide Phosphate with in Vivo 3.0-T31P MR Spectroscopy with Proton Decoupling

(2010) Ksenia Sevastianova et al.   RADIOLOGY

Perspective: Does brown fat protect against diseases of aging?

(2009) Mark P. Mattson   AGEING RESEARCH REVIEWS

Increased subsarcolemmal lipids in type 2 diabetes: effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle

(2009) Joachim Nielsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity

(2009) Vladimir B. Ritov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Comparison of methods for measuring oxygen consumption in tumor cells in vitro

(2009) Caroline Diepart et al.   ANALYTICAL BIOCHEMISTRY

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Short-Term Exercise Training Does Not Stimulate Skeletal Muscle ATP Synthesis in Relatives of Humans With Type 2 Diabetes

(2009) G. Kacerovsky-Bielesz et al.   DIABETES

Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes

(2009) H. Hwang et al.   DIABETES

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

(2009) R. C.R. Meex et al.   DIABETES

Age, Obesity, and Sex Effects on Insulin Sensitivity and Skeletal Muscle Mitochondrial Function

(2009) H. Karakelides et al.   DIABETES

Impaired Mitochondrial Function and Insulin Resistance of Skeletal Muscle in Mitochondrial Diabetes

(2009) J. Szendroedi et al.   DIABETES CARE

Continuous low- to moderate-intensity exercise training is as effective as moderate- to high-intensity exercise training at lowering blood HbA1c in obese type 2 diabetes patients

(2009) D. Hansen et al.   DIABETOLOGIA

Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial

(2009) D. K. Coletta et al.   DIABETOLOGIA

Abnormal hepatic energy homeostasis in type 2 diabetes

(2009) Julia Szendroedi et al.   HEPATOLOGY

Capacity of oxidative phosphorylation in human skeletal muscle

(2009) Erich Gnaiger   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Carnitine Insufficiency Caused by Aging and Overnutrition Compromises Mitochondrial Performance and Metabolic Control

(2009) Robert C. Noland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Short-Term Free Fatty Acids Elevation on Mitochondrial Function in Skeletal Muscle of Healthy Individuals

(2009) Alberto O. Chavez et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondria and diabetes mellitus: untangling a conflictive relationship?

(2009) M. Schiff et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Plasma Acylcarnitine Profiles Suggest Incomplete Long-Chain Fatty Acid β-Oxidation and Altered Tricarboxylic Acid Cycle Activity in Type 2 Diabetic African-American Women

(2009) Sean H. Adams et al.   JOURNAL OF NUTRITION

Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy

(2009) Luuk J. Rijzewijk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human Heart

(2009) Ethan J. Anderson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Reduced skeletal muscle mitochondrial respiration and improved glucose metabolism in nondiabetic obese women during a very low calorie dietary intervention leading to rapid weight loss

(2009) Rasmus Rabøl et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance

(2008) John O Holloszy   AMERICAN JOURNAL OF CLINICAL NUTRITION

Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals

(2008) Graham P Holloway et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The interpretation of abnormal 31P magnetic resonance saturation transfer measurements of Pi/ATP exchange in insulin-resistant skeletal muscle

(2008) Graham J. Kemp   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial functionin vivo

(2008) Sudheer K. Mantena et al.   BIOCHEMICAL JOURNAL

Resveratrol inhibits nonalcoholic fatty liver disease in rats

(2008) Luis Bujanda et al.   BMC GASTROENTEROLOGY

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Muscle acylcarnitines during short-term fasting in lean healthy men

(2008) Maarten R. Soeters et al.   CLINICAL SCIENCE

Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients

(2008) E. Phielix et al.   DIABETES

Asian Indians Have Enhanced Skeletal Muscle Mitochondrial Capacity to Produce ATP in Association With Severe Insulin Resistance

(2008) K. S. Nair et al.   DIABETES

Mitochondrial Capacity in Skeletal Muscle Is Not Stimulated by Weight Loss Despite Increases in Insulin Action and Decreases in Intramyocellular Lipid Content

(2008) F. G.S. Toledo et al.   DIABETES

Mitochondrial fitness and insulin sensitivity in humans

(2008) J. Szendroedi et al.   DIABETOLOGIA

Myocardial Steatosis Is an Independent Predictor of Diastolic Dysfunction in Type 2 Diabetes Mellitus

(2008) Luuk J. Rijzewijk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Reduced Basal ATP Synthetic Flux of Skeletal Muscle in Patients with Previous Acromegaly

(2008) Julia Szendroedi et al.   PLoS One

Muscle insulin resistance: A case of fat overconsumption, not mitochondrial dysfunction

(2008) E. W. Kraegen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

(2008) C. R. Hancock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative ATP synthesis in human liver measured by localized31P spectroscopy using the magnetization transfer experiment

(2007) A. I. Schmid et al.   NMR IN BIOMEDICINE