☆ 4.8 Article

Acyldepsipeptide HDAC Inhibitor Production Induced in Burkholderia thailandensis

ORGANIC LETTERS (2011)

期刊

ORGANIC LETTERS

卷 13, 期 6, 页码 1536-1539

出版社

AMER CHEMICAL SOC

DOI: 10.1021/ol200225v

关键词

-

类别

Chemistry, Organic

资金

Northeast Biodefense Center [U54-AI057158]
NIH [GM077516]

向作者/读者索取更多资源

Protocol

Reagent

摘要

Natural product gene clusters are often tightly regulated, resulting in gene cluster silencing in laboratory fermentation studies. The systematic overexpression of transcription factors (TFs) associated with biosynthetic gene clusters found in the genome of Burkholderia thailandensis E264 identified a set of TFs that, when overexpressed, alter the secondary metabolome of this bacterium. The isolation and characterization of burkholdacs A and B, two new acyldepsitripeptide histone deacetylase inhibitors produced by B. thailandensis overexpressing the TF bhcM, is reported.

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Article Biotechnology & Applied Microbiology

Cost-effective rhamnolipid production by Burkholderia thailandensis E264 using agro-industrial residues

Jessica Correia, Eduardo J. Gudina, Zbigniew Lazar, Tomasz Janek, Jose A. Teixeira

Summary: This study reports the first use of agro-industrial by-products as the sole ingredients for rhamnolipid production by Burkholderia thailandensis E264. By combining corn steep liquor and olive mill wastewater, the yield and surface-active properties of rhamnolipids were improved. However, rhamnolipids produced in the CSL + OMW medium exhibited weaker emulsifying activity compared to those produced in other media.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Antibiotic-Loaded Polymersomes for Clearance of Intracellular Burkholderia thailandensis

Eleanor Porges, Dominic Jenner, Adam W. Taylor, James S. P. Harrison, Antonio De Grazia, Alethia R. Hailes, Kimberley M. Wright, Adam O. Whelan, Isobel H. Norville, Joann L. Prior, Sumeet Mahajan, Caroline A. Rowland, Tracey A. Newman, Nicholas D. Evans

Summary: The research team developed polymersomes (PMs) that can effectively deliver antibiotics to intracellular Burkholderia infection, inhibiting their growth. PMs are a targeted antibiotic treatment approach that can reduce bacterial antibiotic resistance.

ACS NANO (2021)

添加到收藏夹

Article Immunology

Burkholderia thailandensis Isolated from the Environment, United States

Carina M. Hall, Nathan E. Stone, Madison Martz, Shelby M. Hutton, Ella Santana-Propper, Lora Versluis, Kieston Guidry, Marielisa Ortiz, Joseph D. Busch, Trevor Maness, Jonathan Stewart, Tom Sidwa, Jay E. Gee, Mindy G. Elrod, Julia K. Petras, Maureen C. Ty, Christopher Gulvik, Zachary P. Weiner, Johanna S. Salzer, Alex R. Hoffmaster, Sarai Rivera-Garcia, Paul Keim, Amanda Kieffer, Jason W. Sahl, Fred Soltero, David M. Wagner

Summary: Burkholderia thailandensis, a bacterium closely related to the pathogen B. pseudomallei, was found in water in Texas and Puerto Rico, as well as soil in Mississippi in the United States. This discovery highlights a potential public health risk, although human infections with B. thailandensis are rare.

EMERGING INFECTIOUS DISEASES (2023)

添加到收藏夹

Article Biology

An IS-mediated, RecA-dependent, bet-hedging strategy in Burkholderia thailandensis

Lillian C. Lowrey, Leslie A. Kent, Bridgett M. Rios, Angelica B. Ocasio, Peggy A. Cotter, Arturo Casadevall

Summary: The phase variation mechanism of Burkholderia thailandensis can enable population heterogeneity through genomic rearrangements, allowing the bacteria to adapt to environmental fluctuations. The presence of duplicate DNA regions with varied copy numbers provides selective advantages for growth in different conditions, expanding the species' ecological repertoire.

ELIFE (2023)

添加到收藏夹

Article Microbiology

Guanylate-Binding Protein-Dependent Noncanonical Inflammasome Activation Prevents Burkholderia thailandensis-Induced Multinucleated Giant Cell Formation

Marisa Dilucca, Saray Ramos, Kateryna Shkarina, Jose Carlos Santos, Petr Broz

Summary: Inflammasomes are cytosolic signaling complexes activated by pathogen-derived ligands or endogenous danger signals, leading to cell death and cytokine release. Interferons play a regulatory role in inflammasome activation through GBPs and can confer protection against pathogens by inducing pyroptosis via caspase-4.

MBIO (2021)

添加到收藏夹

Article Microbiology

Sustainable rhamnolipids production in the next decade-Advancing with Burkholderia thailandensis as a potent biocatalytic strain

Rajat Kumar, Rahul Islam Barbhuiya, Varsha Bohra, Jonathan W. C. Wong, Ashutosh Singh, Guneet Kaur

Summary: This review discusses the sustainable biosynthesis of rhamnolipids using Burkholderia thailandensis E264, emphasizing on its metabolism, regulation, upscaling, and applications. The study highlights that by optimizing the use of low-cost substrates, industrial rhamnolipids can be promoted in advanced biorefinery domains, enabling circular economy, reducing carbon footprint, and increasing the applicability of socially and environmentally friendly bioproducts.

MICROBIOLOGICAL RESEARCH (2023)

添加到收藏夹

Article Microbiology

The Global Regulator MftR Controls Virulence and Siderophore Production in Burkholderia thailandensis

Sudarshan S. Thapa, Ahmed Al-Tohamy, Anne Grove

Summary: In Burkholderia thailandensis, disruption of the mftR gene leads to increased virulence, enhanced biofilm formation, and elevated motility. MftR is shown to control the production of the siderophore malleobactin, a primary siderophore in this bacterium. These findings highlight the role of MftR in regulating bacterial survival in a host environment through various phenotypes.

JOURNAL OF BACTERIOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Piperacillin triggers virulence factor biosynthesis via the oxidative stress response in Burkholderia thailandensis

Anran Li, Bethany K. Okada, Paul C. Rosen, Mohammad R. Seyedsayamdost

Summary: Natural products are important sources of therapeutic agents and chemical tools. This study identified beta-lactams, fluoroquinolones, antifungals, and unexpected drugs as potent inducers of biosynthetic genes in Burkholderia thailandensis, shedding light on the regulatory mechanisms of these genes. The work uncovers a diverse array of elicitors and previously unknown regulatory inputs for secondary metabolism in B. thailandensis.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Biochemical Research Methods

Engineered Biosynthesis of Complex Disorazol Polyketides in a Streamlined Burkholderia thailandensis

Zong-Jie Wang, Xiaotong Liu, Haibo Zhou, Yang Liu, Qiang Tu, Liujie Huo, Fu Yan, Rolf Mueller, Youming Zhang, Xiaokun Xu

Summary: Engineering the biosynthetic pathways of complex natural products is a significant approach to obtain derivatives with improved properties. Here, we constructed a streamlined engineered biosynthesis system of myxobacterium-derived complex polyketide disorazol in a heterologous host. The inactivation of dehydratase domains led to the production of hydroxylated derivatives, while module deletion allowed the generation of an unnatural derivative with a truncated macrolactone ring. These disorazol derivatives showed different activities against human cancer cell lines, indicating a structure-activity relationship. The PKS engineering enables structural derivatization of disorazol, facilitating the in-depth engineered biosynthesis of polyketides.

ACS SYNTHETIC BIOLOGY (2023)

添加到收藏夹

Article Polymer Science

Characterization of the Thermostable Biosurfactant Produced by Burkholderia thailandensis DSM 13276

Catia Gil, Ana Teresa Rebocho, Asiyah Esmail, Chantal Sevrin, Christian Grandfils, Cristiana A. Torres, Maria A. M. Reis, Filomena Freitas

Summary: Biosurfactants synthesized by microorganisms are safe and sustainable alternatives to synthetic surfactants. This study characterizes a biopolymer secreted by Burkholderia thailandensis, highlighting its potential as a biosurfactant. The biopolymer is a glycolipopeptide with carbohydrate and protein contents of 33.1% and 23.0%, respectively. It displays good emulsion-stabilizing capacity and can form stable emulsions with hydrophobic compounds.

POLYMERS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

The HDAC/HSP90 Inhibitor G570 Attenuated Blue Light-Induced Cell Migration in RPE Cells and Neovascularization in Mice through Decreased VEGF Production

Tai-Ju Hsu, Kunal Nepali, Chi-Hao Tsai, Zuha Imtiyaz, Fan-Li Lin, George Hsiao, Mei-Jung Lai, Yu-Wen Cheng

Summary: AMD, caused by abnormalities in RPE cells, currently lacks diverse treatment options, with anti-VEGF agents being the main therapy despite associated side effects. The study showcases the potential of dual-target modulator G570 in treating wet AMD, indicating promising therapeutic developments in the future.

MOLECULES (2021)

添加到收藏夹

Article Microbiology

Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia thailandensis Pathogenesis

David E. Place, Shelbi Christgen, Shraddha Tuladhar, Peter Vogel, R. K. Subbarao Malireddi, Thirumala-Devi Kanneganti

Summary: This study shows the importance of pyroptosis and apoptosis in host-mediated control of Burkholderia infection. Loss of key components of these pathways results in increased cell death and bacterial intercellular spread during infection. In the absence of these pathways, host control of infection is compromised, leading to higher mortality rates in mice.

MBIO (2021)

添加到收藏夹

Article Metallurgy & Metallurgical Engineering

Influence of biosurfactants in the recovery of REE from monazite using Burkholderia thailandensis

Laura Castro, Helena Gomez-Alvarez, Manuel Carmona, Felisa Gonzalez, Jesus A. Munoz

Summary: The aim of this study was to investigate the solubilization of monazite and recovery of REE using Burkholderia thailandensis, and the influence of the rhamnolipids produced by the bacteria on REE mobilization. B. thailandensis grown in nutrient broth with 1% monazite (w/v) achieved a REE concentration of 8.3 mg center dot l-1 after 15 days. Rhamnolipids were produced by B. thailandensis grown in medium supplemented with 10% glycerol, and the critical micelle concentration (CMC) was determined to be 94.45 mg center dot l-1 for commercial rhamnolipids and 60.41 mg center dot l-1 for purified rhamnolipids. The maximum REE solubilization was achieved at CMC, with 9.36 mg center dot l-1 for commercial rhamnolipids and 5.13 mg center dot l-1 for rhamnolipids produced by B. thailandensis E264.

HYDROMETALLURGY (2023)

添加到收藏夹

Article Cell Biology

Plasma membrane protrusions mediate host cell-cell fusion induced by Burkholderia thailandensis

Nora Kostow, Matthew D. Welch

Summary: Bacteria use actin-based motility to form protrusions on the host cell plasma membrane, which extend into neighboring cells and promote membrane fusion. The T6SS-5 effectors VgrG5 and TagD5 are essential for promoting cell-cell fusion within the protrusions.

MOLECULAR BIOLOGY OF THE CELL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

NosP Detection of Heme Modulates Burkholderia thailandensis Biofilm Formation

Jiayuan Fu, Lisa-Marie Nisbett, Yulong Guo, Elizabeth M. Boon

Summary: Aggregated bacteria in biofilms, which are resistant to antibiotics, are a major public health threat. Heme, an iron source for pathogenic bacteria during infection, is correlated with the transition from acute to chronic infection. A newly discovered hemoprotein called NosP is found to have heme-sensing function and regulates biofilms in Burkholderia thailandensis. The studies suggest that NosP binds to heme, inhibits its associated histidine kinase, and decreases biofilm formation.

BIOCHEMISTRY (2023)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

Minimum Information about a Biosynthetic Gene cluster

Marnix H. Medema, Renzo Kottmann, Pelin Yilmaz, Matthew Cummings, John B. Biggins, Kai Blin, Irene de Bruijn, Yit Heng Chooi, Jan Claesen, R. Cameron Coates, Pablo Cruz-Morales, Srikanth Duddela, Stephanie Duesterhus, Daniel J. Edwards, David P. Fewer, Neha Garg, Christoph Geiger, Juan Pablo Gomez-Escribano, Anja Greule, Michalis Hadjithomas, Anthony S. Haines, Eric J. N. Helfrich, Matthew L. Hillwig, Keishi Ishida, Adam C. Jones, Carla S. Jones, Katrin Jungmann, Carsten Kegler, Hyun Uk Kim, Peter Koetter, Daniel Krug, Joleen Masschelein, Alexey V. Melnik, Simone M. Mantovani, Emily A. Monroe, Marcus Moore, Nathan Moss, Hans-Wilhelm Nuetzmann, Guohui Pan, Amrita Pati, Daniel Petras, F. Jerry Reen, Federico Rosconi, Zhe Rui, Zhenhua Tian, Nicholas J. Tobias, Yuta Tsunematsu, Philipp Wiemann, Elizabeth Wyckoff, Xiaohui Yan, Grace Yim, Fengan Yu, Yunchang Xie, Bertrand Aigle, Alexander K. Apel, Carl J. Balibar, Emily P. Balskus, Francisco Barona-Gomez, Andreas Bechthold, Helge B. Bode, Rainer Borriss, Sean F. Brady, Axel A. Brakhage, Patrick Caffrey, Yi-Qiang Cheng, Jon Clardy, Russell J. Cox, Rene De Mot, Stefano Donadio, Mohamed S. Donia, Wilfred A. van der Donk, Pieter C. Dorrestein, Sean Doyle, Arnold J. M. Driessen, Monika Ehling-Schulz, Karl-Dieter Entian, Michael A. Fischbach, Lena Gerwick, William H. Gerwick, Harald Gross, Bertolt Gust, Christian Hertweck, Monica Hofte, Susan E. Jensen, Jianhua Ju, Leonard Katz, Leonard Kaysser, Jonathan L. Klassen, Nancy P. Keller, Jan Kormanec, Oscar P. Kuipers, Tomohisa Kuzuyama, Nikos C. Kyrpides, Hyung-Jin Kwon, Sylvie Lautru, Rob Lavigne, Chia Y. Lee, Bai Linquan, Xinyu Liu, Wen Liu, Andriy Luzhetskyy, Taifo Mahmud, Yvonne Mast, Carmen Mendez, Mikko Metsa-Ketela, Jason Micklefield, Douglas A. Mitchell, Bradley S. Moore, Leonilde M. Moreira, Rolf Mueller, Brett A. Neilan, Markus Nett, Jens Nielsen, Fergal O'Gara, Hideaki Oikawa, Anne Osbourn, Marcia S. Osburne, Bohdan Ostash, Shelley M. Payne, Jean-Luc Pernodet, Miroslav Petricek, Joern Piel, Olivier Ploux, Jos M. Raaijmakers, Jose A. Salas, Esther K. Schmitt, Barry Scott, Ryan F. Seipke, Ben Shen, David H. Sherman, Kaarina Sivonen, Michael J. Smanski, Margherita Sosio, Evi Stegmann, Roderich D. Suessmuth, Kapil Tahlan, Christopher M. Thomas, Yi Tang, Andrew W. Truman, Muriel Viaud, Jonathan D. Walton, Christopher T. Walsh, Tilmann Weber, Gilles P. van Wezel, Barrie Wilkinson, Joanne M. Willey, Wolfgang Wohlleben, Gerard D. Wright, Nadine Ziemert, Changsheng Zhang, Sergey B. Zotchev, Rainer Breitling, Eriko Takano, Frank Oliver Gloeckner

NATURE CHEMICAL BIOLOGY (2015)

添加到收藏夹

Editorial Material Medicine, General & Internal

Conduction Dysfunction and Near Expunction: Giant Cell Myocarditis

Conrad Gleber, Ayhan Yoruk, Luke Eastburg, Bruce I. Goldman, Scott J. Cameron

AMERICAN JOURNAL OF MEDICINE (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Light-Activated Gene Expression Directs Segregation of Co-cultured Cells in Vitro

Daniel J. Sauers, Murali K. Temburni, John B. Biggins, Luke M. Ceo, Den S. Galileo, John T. Koh

ACS CHEMICAL BIOLOGY (2010)

添加到收藏夹

Article Chemistry, Multidisciplinary

Metabolites from the Induced Expression of Cryptic Single Operons Found in the Genome of Burkholderia pseudomallei

John B. Biggins, Xiaofei Liu, Zhiyang Feng, Sean F. Brady

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

添加到收藏夹

Article Chemistry, Multidisciplinary

Malleilactone, a Polyketide Synthase-Derived Virulence Factor Encoded by the Cryptic Secondary Metabolome of Burkholderia pseudomallei Group Pathogens

John B. Biggins, Melinda A. Ternei, Sean F. Brady

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

The Chemical Arsenal of Burkholderia pseudomallei Is Essential for Pathogenicity

John B. Biggins, Hahk-Soo Kang, Melinda A. Ternei, David DeShazer, Sean F. Brady

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

添加到收藏夹

Review Oncology

A review of thrombotic microangiopathies in multiple myeloma

Andrew Jay Portuguese, Conrad Gleber, Frank C. Passero, Brea Lipe

LEUKEMIA RESEARCH (2019)

添加到收藏夹

Editorial Material Geriatrics & Gerontology

Shaping the Future of Older Adult Care: ChatGPT, Advanced AI, and the Transformation of Clinical Practice

Kathleen Fear, Conrad Gleber

Summary: With the growth of the older adult population in the United States, new approaches are needed to manage and streamline clinical work to meet the increased demand for healthcare.

JMIR AGING (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Photocaged agonist for an analogue-specific form of the vitamin D receptor

John B. Biggins, Atsushi Hashimoto, John T. Koh

CHEMBIOCHEM (2007)

添加到收藏夹

Review Biochemistry & Molecular Biology

Chemical biology of steroid and nuclear hormone receptors

John B. Biggins, John T. Koh

CURRENT OPINION IN CHEMICAL BIOLOGY (2007)

添加到收藏夹

Article Chemistry, Organic

Studies on the substrate specificity of Escherichia coli galactokinase

J Yang, X Fu, Q Jia, J Shen, JB Biggins, JQ Jiang, JJ Zhao, JJ Schmidt, PG Wang, JS Thorson

ORGANIC LETTERS (2003)

添加到收藏夹

Article Chemistry, Organic

Substrate specificity of NovM: Implications for novobiocin biosynthesis and glycorandomization

C Albermann, A Soriano, JQ Jiang, H Vollmer, JB Biggins, WA Barton, J Lesniak, DB Nikolov, JS Thorson

ORGANIC LETTERS (2003)

添加到收藏夹

Review Chemistry, Medicinal

Ligand-receptor engineering and its application towards the complementation of genetic disease and target identification

JT Koh, JB Biggins

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2005)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.