Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic

Porcine Reproductive and Respiratory Syndrome Virus Subverts Repertoire Development by Proliferation of Germline-Encoded B Cells of All Isotypes Bearing Hydrophobic Heavy Chain CDR3

(2014) J. E. Butler et al.   JOURNAL OF IMMUNOLOGY

In vivo discovery of immunotherapy targets in the tumour microenvironment

(2014) Penghui Zhou et al.   NATURE

Adaptation of a commercial ELISA to determine the IgG avidity in sheep experimentally and naturally infected with Neospora caninum

(2014) S.S. Syed-Hussain et al.   VETERINARY PARASITOLOGY

Potential Role of Porcine Reproductive and Respiratory Syndrome Virus Structural Protein GP2 in Apoptosis Inhibition

(2014) Sujit Pujhari et al.   Biomed Research International

Antibody repertoire development in fetal and neonatal piglets. XVI. Influenza stimulates adaptive immunity, class switch and diversification of the IgG repertoire encoded by downstream Cγ genes

(2013) John E. Butler et al.   IMMUNOLOGY

Arterivirus molecular biology and pathogenesis

(2013) E. J. Snijder et al.   JOURNAL OF GENERAL VIROLOGY

Highly Divergent Strains of Porcine Reproductive and Respiratory Syndrome Virus Incorporate Multiple Isoforms of Nonstructural Protein 2 into Virions

(2013) M. A. Kappes et al.   JOURNAL OF VIROLOGY

Recombination Is Associated with an Outbreak of Novel Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Viruses in China

(2013) M. Shi et al.   JOURNAL OF VIROLOGY

Porcine Reproductive and Respiratory Syndrome Virus Nsp1  Inhibits Interferon-Activated JAK/STAT Signal Transduction by Inducing Karyopherin- 1 Degradation

(2013) R. Wang et al.   JOURNAL OF VIROLOGY

Broadening the Heterologous Cross-Neutralizing Antibody Inducing Ability of Porcine Reproductive and Respiratory Syndrome Virus by Breeding the GP4 or M genes

(2013) Lei Zhou et al.   PLoS One

Signal Peptide Cleavage from GP5 of PRRSV: A Minor Fraction of Molecules Retains the Decoy Epitope, a Presumed Molecular Cause for Viral Persistence

(2013) Bastian Thaa et al.   PLoS One

Identification of Cytotoxic T Lymphocyte Epitopes on Swine Viruses: Multi-Epitope Design for Universal T Cell Vaccine

(2013) Yu-Chieh Liao et al.   PLoS One

Enhancing neutralizing antibody production by an interferon-inducing porcine reproductive and respiratory syndrome virus strain

(2013) Rong Wang et al.   VACCINE

Variable interference with interferon signal transduction by different strains of porcine reproductive and respiratory syndrome virus

(2013) Rong Wang et al.   VETERINARY MICROBIOLOGY

Molecular evolution of PRRSV in Europe: Current state of play

(2013) Tomasz Stadejek et al.   VETERINARY MICROBIOLOGY

Replacement of the heterologous 5′ untranslated region allows preservation of the fully functional activities of type 2 porcine reproductive and respiratory syndrome virus

(2013) Fei Gao et al.   VIROLOGY

Chinese and Vietnamese strains of HP-PRRSV cause different pathogenic outcomes in United States high health swine

(2013) Baoqing Guo et al.   VIROLOGY

Lymphodepletion and Homeostatic Proliferation: Implications for Transplantation

(2012) N. K. Tchao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Presence of Alpha Interferon at the Time of Infection Alters the Innate and Adaptive Immune Responses to Porcine Reproductive and Respiratory Syndrome Virus

(2012) Susan L. Brockmeier et al.   Clinical and Vaccine Immunology

Linkage haplotype for allotypic variants of porcine IgA and IgG subclass genes

(2012) A. Kloep et al.   IMMUNOGENETICS

Role of porcine reproductive and respiratory syndrome virus nucleocapsid protein in induction of interleukin-10 and regulatory T-lymphocytes (Treg)

(2012) P. Wongyanin et al.   JOURNAL OF GENERAL VIROLOGY

Nonstructural Protein 2 of Porcine Reproductive and Respiratory Syndrome Virus Inhibits the Antiviral Function of Interferon-Stimulated Gene 15

(2012) Z. Sun et al.   JOURNAL OF VIROLOGY

Arterivirus Minor Envelope Proteins Are a Major Determinant of Viral Tropism in Cell Culture

(2012) D. Tian et al.   JOURNAL OF VIROLOGY

Attenuation of Porcine Reproductive and Respiratory Syndrome Virus by Molecular Breeding of Virus Envelope Genes from Genetically Divergent Strains

(2012) Y.-Y. Ni et al.   JOURNAL OF VIROLOGY

Resolution of an immunodiagnostic dilemma: Heavy chain chimeric antibodies for species in which plasmocytomas are unknown

(2012) J.E. Butler et al.   MOLECULAR IMMUNOLOGY

Efficient -2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein

(2012) Y. Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody repertoire development in fetal and neonatal piglets. XXIII: Fetal piglets infected with a vaccine strain of PRRS Virus display the same immune dysregulation seen in isolator piglets

(2012) X.-Z. Sun et al.   VACCINE

Characterization of thymus atrophy in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus

(2012) Yuli He et al.   VETERINARY MICROBIOLOGY

Porcine reproductive and respiratory syndrome virus activates the transcription of interferon alpha/beta (IFN-α/β) in monocyte-derived dendritic cells (Mo-DC)

(2012) Hanmo Zhang et al.   VETERINARY MICROBIOLOGY

Porcine reproductive and respiratory syndrome virus induces CD4+CD8+CD25+Foxp3+ regulatory T cells (Tregs)

(2012) Erika Silva-Campa et al.   VIROLOGY

Chimeric viruses containing the N-terminal ectodomains of GP5 and M proteins of porcine reproductive and respiratory syndrome virus do not change the cellular tropism of equine arteritis virus

(2012) Zhengchun Lu et al.   VIROLOGY

Dissociation of porcine reproductive and respiratory syndrome virus neutralization from antibodies specific to major envelope protein surface epitopes

(2012) Juan Li et al.   VIROLOGY

DNA shuffling of the GP3 genes of porcine reproductive and respiratory syndrome virus (PRRSV) produces a chimeric virus with an improved cross-neutralizing ability against a heterologous PRRSV strain

(2012) Lei Zhou et al.   VIROLOGY

Induction of type I interferons by a novel porcine reproductive and respiratory syndrome virus isolate

(2012) Yuchen Nan et al.   VIROLOGY

Identification of amino acid residues important for anti-IFN activity of porcine reproductive and respiratory syndrome virus non-structural protein 1

(2012) Lalit K. Beura et al.   VIROLOGY

Glycosyl-phosphatidylinositol (GPI)-anchored membrane association of the porcine reproductive and respiratory syndrome virus GP4 glycoprotein and its co-localization with CD163 in lipid rafts

(2012) Yijun Du et al.   VIROLOGY

Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus

(2012) Baoqing Guo et al.   VIROLOGY

Interplay between Interferon-Mediated Innate Immunity and Porcine Reproductive and Respiratory Syndrome Virus

(2012) Yan Sun et al.   Viruses-Basel

Porcine reproductive and respiratory syndrome virus nucleocapsid protein modulates interferon-β production by inhibiting IRF3 activation in immortalized porcine alveolar macrophages

(2011) Mingeun Sagong et al.   ARCHIVES OF VIROLOGY

Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses

(2011) C. R. Johnson et al.   JOURNAL OF GENERAL VIROLOGY

Rapid and Transient Activation of    T Cells to IFN-  Production, NK Cell-Like Killing, and Antigen Processing during Acute Virus Infection

(2011) F. N. Toka et al.   JOURNAL OF IMMUNOLOGY

Immune Evasion of Porcine Reproductive and Respiratory Syndrome Virus through Glycan Shielding Involves both Glycoprotein 5 as Well as Glycoprotein 3

(2011) H. L. X. Vu et al.   JOURNAL OF VIROLOGY

Antibody repertoire development in fetal and neonatal piglets

(2011) John E. Butler et al.   MOLECULAR IMMUNOLOGY

Immunological solutions for treatment and prevention of porcine reproductive and respiratory syndrome (PRRS)

(2011) Michael P. Murtaugh et al.   VACCINE

Characterization of antigenic regions in the porcine reproductive and respiratory syndrome virus by the use of peptide-specific serum antibodies

(2011) Merijn Vanhee et al.   VACCINE

Identification of a novel nidovirus associated with a neurological disease of the Australian brushtail possum (Trichosurus vulpecula)

(2011) M. Dunowska et al.   VETERINARY MICROBIOLOGY

Chimeric porcine reproductive and respiratory syndrome viruses reveal full function of genotype 1 envelope proteins in the backbone of genotype 2

(2011) Debin Tian et al.   VIROLOGY

Genetic and phenotypic characterization of a 2006 United States porcine reproductive and respiratory virus isolate associated with high morbidity and mortality in the field

(2011) Phillip C. Gauger et al.   VIRUS RESEARCH

GP4 of porcine reproductive and respiratory syndrome virus contains a neutralizing epitope that is susceptible to immunoselection in vitro

(2010) Sarah Costers et al.   ARCHIVES OF VIROLOGY

Induction of Foot-and-Mouth Disease Virus-Specific Cytotoxic T Cell Killing by Vaccination

(2010) Jared R. Patch et al.   Clinical and Vaccine Immunology

Porcine Reproductive and Respiratory Syndrome Virus Inhibits Type I Interferon Signaling by Blocking STAT1/STAT2 Nuclear Translocation

(2010) D. Patel et al.   JOURNAL OF VIROLOGY

North American Porcine Reproductive and Respiratory Syndrome Viruses Inhibit Type I Interferon Production by Plasmacytoid Dendritic Cells

(2010) G. Calzada-Nova et al.   JOURNAL OF VIROLOGY

The Cysteine Protease Domain of Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Possesses Deubiquitinating and Interferon Antagonism Functions

(2010) Z. Sun et al.   JOURNAL OF VIROLOGY

Vaccine efficacy of porcine reproductive and respiratory syndrome virus chimeras

(2010) Joshua S. Ellingson et al.   VACCINE

Porcine Reproductive and Respiratory Syndrome Virus–Induced Immunosuppression Exacerbates the Inflammatory Response to Porcine Respiratory Coronavirus in Pigs

(2010) Gourapura J. Renukaradhya et al.   VIRAL IMMUNOLOGY

Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells

(2010) Oekyung Kim et al.   VIROLOGY

Glycosylation of minor envelope glycoproteins of porcine reproductive and respiratory syndrome virus in infectious virus recovery, receptor interaction, and immune response

(2010) Phani B. Das et al.   VIROLOGY

Secondary infection with Streptococcus suis serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs

(2010) Min Xu et al.   Virology Journal

The interaction between PRRSV and the late gestation pig fetus

(2010) Raymond R.R. Rowland   VIRUS RESEARCH

Modulation of host cell responses and evasion strategies for porcine reproductive and respiratory syndrome virus

(2010) Dongwan Yoo et al.   VIRUS RESEARCH

The structural biology of PRRSV

(2010) Terje Dokland   VIRUS RESEARCH

Control and elimination of porcine reproductive and respiratory syndrome virus

(2010) Cesar A. Corzo et al.   VIRUS RESEARCH

A virulent strain of porcine reproductive and respiratory syndrome virus does not up-regulate interleukin-10 levels in vitro or in vivo

(2010) Sakthivel Subramaniam et al.   VIRUS RESEARCH

Recombination analyses between two strains of porcine reproductive and respiratory syndrome virus in vivo

(2010) Dan Liu et al.   VIRUS RESEARCH

Antibody Response to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Nonstructural Proteins and Implications for Diagnostic Detection and Differentiation of PRRSV Types I and II

(2009) E. Brown et al.   Clinical and Vaccine Immunology

Cryo-electron tomography of porcine reproductive and respiratory syndrome virus: organization of the nucleocapsid

(2009) M. S. Spilman et al.   JOURNAL OF GENERAL VIROLOGY

Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 1  Modulates Host Innate Immune Response by Antagonizing IRF3 Activation

(2009) L. K. Beura et al.   JOURNAL OF VIROLOGY

The 30-Amino-Acid Deletion in the Nsp2 of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Emerging in China Is Not Related to Its Virulence

(2009) L. Zhou et al.   JOURNAL OF VIROLOGY

Efficacy of a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in pigs naturally exposed to a heterologous European (Italian cluster) field strain: Clinical protection and cell-mediated immunity

(2009) Paolo Martelli et al.   VACCINE

Induction of inducible CD4+CD25+Foxp3+ regulatory T lymphocytes by porcine reproductive and respiratory syndrome virus (PRRSV)

(2009) P. Wongyanin et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Characterization of the cytokine and maturation responses of pure populations of porcine plasmacytoid dendritic cells to porcine viruses and toll-like receptor agonists

(2009) Gabriela Calzada-Nova et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Vaccine efficacy and immune response to swine influenza virus challenge in pigs infected with porcine reproductive and respiratory syndrome virus at the time of SIV vaccination

(2009) Pravina Kitikoon et al.   VETERINARY MICROBIOLOGY

Functional impairment of PRRSV-specific peripheral CD3+CD8highcells

(2009) Sarah Costers et al.   VETERINARY RESEARCH

Adenovirus-Mediated Expression of Interferon-α Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus

(2009) S.L. Brockmeier et al.   VIRAL IMMUNOLOGY

Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist

(2009) Z. Chen et al.   VIROLOGY

Age-dependent resistance to Porcine reproductive and respiratory syndrome virus replication in swine

(2009) Kelly L Klinge et al.   Virology Journal

Recovery of viable porcine reproductive and respiratory syndrome virus from an infectious clone containing a partial deletion within the Nsp2-encoding region

(2008) Z. G. Ran et al.   ARCHIVES OF VIROLOGY

Structural Insights into the Mechanisms of Antibody-Mediated Neutralization of Flavivirus Infection: Implications for Vaccine Development

(2008) Theodore C. Pierson et al.   Cell Host & Microbe

Porcine IgG: structure, genetics, and evolution

(2008) J. E. Butler et al.   IMMUNOGENETICS

The nsp1  and nsp1 papain-like autoproteinases are essential for porcine reproductive and respiratory syndrome virus RNA synthesis

(2008) M. V. Kroese et al.   JOURNAL OF GENERAL VIROLOGY

An infectious cDNA clone of a highly pathogenic porcine reproductive and respiratory syndrome virus variant associated with porcine high fever syndrome

(2008) J. Lv et al.   JOURNAL OF GENERAL VIROLOGY

Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-β production by interfering with the RIG-I signaling pathway

(2008) Rui Luo et al.   MOLECULAR IMMUNOLOGY

Identification of immunodominant T-cell epitopes present in glycoprotein 5 of the North American genotype of porcine reproductive and respiratory syndrome virus

(2008) Kapil Vashisht et al.   VACCINE

The piglet as a model for B cell and immune system development

(2008) J.E. Butler et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Identification of virulence determinants of porcine reproductive and respiratory syndrome virus through construction of chimeric clones

(2008) Byungjoon Kwon et al.   VIROLOGY

Molecular assessment of the role of envelope-associated structural proteins in cross neutralization among different PRRS viruses

(2008) Won-Il Kim et al.   VIRUS GENES

Functional mapping of the porcine reproductive and respiratory syndrome virus capsid protein nuclear localization signal and its pathogenic association

(2008) Yanlong Pei et al.   VIRUS RESEARCH

Porcine circoviruses: a minuscule yet mammoth paradox

(2008) Sheela Ramamoorthy et al.   ANIMAL HEALTH RESEARCH REVIEWS

The challenge of PRRS immunology

(2007) E. Mateu et al.   VETERINARY JOURNAL

Attenuation of porcine reproductive and respiratory syndrome virus strain MN184 using chimeric construction with vaccine sequence

(2007) Yue Wang et al.   VIROLOGY