Article
Veterinary Sciences
Nanhua Chen, Xinshuai Li, Yanzhao Xiao, Shubin Li, Jianzhong Zhu
Summary: Research has shown that PRRS viruses derived from MLVs are circulating and evolving in Chinese swine herds for years, emphasizing the necessity for the fair use of PRRS MLVs.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Agriculture, Dairy & Animal Science
Huawei Li, Qin Luo, Huiyuan Jing, Yuzhen Song, Weili Kong, Mengmeng Zhao, Qingge Zhu
Summary: Research on the NSP7 protein is crucial for the diagnosis, prevention, and control of porcine reproductive and respiratory syndrome virus (PRRSV). We summarize its genetic variation, recombination hotspots and breakpoints, replication, virulence, immune mechanisms, and interaction with viral proteins and host proteins, offering theoretical support for its application in PRRS diagnosis, novel vaccine design, and therapeutic drug development.
Article
Virology
Go-Eun Shin, Ji-Young Park, Kyoung-Ki Lee, Bok-Kyung Ku, Choi-Kyu Park, Hye-Young Jeoung
Summary: This study successfully isolated and determined recombinant strains between a commercial modified live virus (MLV) vaccine strain and field strains of Porcine reproductive and respiratory syndrome virus (PRRSV) in Korea. Genetic analysis of these strains provides important insights into MLV evolution and PRRSV genetic diversity, emphasizing the need for continuous surveillance of PRRSV.
Article
Veterinary Sciences
Giovani Trevisan, Drew Magstadt, Amy Woods, Joel Sparks, Michael Zeller, Ganwu Li, Karen M. Krueger, Anugrah Saxena, Jianqiang Zhang, Phillip C. Gauger
Summary: A recombinant strain of porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2) was identified from a 4.5-month-old pig in Indiana, USA, without any observed signs of PRRSV infection. Phylogenetic and evolutionary analysis revealed that the strain, PRRSV USA/IN105404/2021, was a natural recombinant of two modified live virus vaccines commercially available in the United States. This is the first report of a PRRSV-2 recombinant strain composed solely of vaccine strains under field conditions. Based on clinical data and the absence of lung lesions, this recombinant strain appears to be non-virulent in swine, but further clinical trials are needed to confirm its pathogenicity.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Microbiology
Tong-Yun Wang, Ming-Xia Sun, Hong-Liang Zhang, Gang Wang, Guoqing Zhan, Zhi-Jun Tian, Xue-Hui Cai, Chenhe Su, Yan-Dong Tang
Summary: Innate immunity serves as the initial defense against viral infections, but viruses like PRRSV have evolved various strategies to evade it. PRRSV, a highly destructive virus in the global swine industry, utilizes multiple strategies to avoid porcine innate immune responses. Understanding the evasion mechanisms employed by PRRSV can aid in developing more effective methods to control and eliminate the virus.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Veterinary Sciences
G. Rawal, J. Angulo, D. C. L. Linhares, C. K. Mah, I. Van Vlaenderen, B. Poulsen Nautrup
Summary: This study evaluated the overall efficacy of the Fostera PRRS vaccine using meta-analytic techniques. The results showed that vaccinated pigs had higher weight gain, lower mortality, reduced lung lesions, and decreased viral load, confirming the effectiveness of the vaccine against heterologous PRRSV.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Microbiology
Ruwini Rupasinghe, Kyuyoung Lee, Xin Liu, Phillip C. Gauger, Jianqiang Zhang, Beatriz Martinez-Lopez
Summary: PRRSV, known for its high genetic and antigenic variability, poses a significant economic threat to the US swine industry. This study evaluated ORF5 sequences of PRRSV-2 strains from 2001 to 2020 in two swine production systems in the midwestern US and identified potential challenges in existing vaccination programs due to genetic diversity.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Rong Wang, Yueqiang Xiao, Qian Zhang, Liang Bai, Weirong Wang, Sihai Zhao, Enqi Liu
Summary: This study demonstrated that highly pathogenic PRRSV strain HuN4 induced significant secretion of HMGB1 and inflammatory cytokines in the bronchoalveolar lavage fluid (BALF), resulting in severe interstitial pneumonia in pigs. In contrast, infection with an avirulent PRRSV vaccine strain CH1R led to mild lung inflammation with minimal HMGB1 secretion.
VETERINARY MICROBIOLOGY
(2021)
Article
Virology
Suya Zheng, Han Gu, Guangwei Han, Huiling Xu, Zehui Liu, Ying Lu, Fang He
Summary: MCPIP1 is identified as a host antiviral protein against PRRSV, while PRRSV nsp11 employs IL-17 induction to suppress MCPIP1 expression and counteract its antiviral effects. Mutations in nsp11 can restore MCPIP1 expression, offering a potential strategy for developing attenuated vaccines against PRRSV.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Chang-Gi Jeong, Amina Khatun, Salik Nazki, Seung-Chai Kim, Yun-Hee Noh, Sang-Chul Kang, Dong-Uk Lee, Myeon-Sik Yang, Nadeem Shabir, In-Joong Yoon, Bumseok Kim, Won-Il Kim
Summary: The chimeric PRRS vaccine JB1 is safe and effective, providing simultaneous protection against two genetically different PRRSV strains, with pregnant sows and piglets both showing significant improvements in viremia levels, antibody production, abortion rates, piglet viability, and viral concentrations.
Article
Microbiology
Lirun Xiang, Hu Xu, Chao Li, Yan-Dong Tang, Tong-Qing An, Zhen Li, Chunxiao Liu, Shuaijie Song, Jing Zhao, Chaoliang Leng, Xiangyang Qu, Yingjun Sun, Jinmei Peng, Qian Wang, Xuehui Cai, Zhi-Jun Tian, Hongliang Zhang
Summary: This study conducted a 4-year monitoring on PRRSV samples from a pig farm in China and discovered that NADC30-like PRRSVs have replaced HP-PRRSVs as dominant strains. The high mutation rate of NADC30-like PRRSVs contributes to their low genomic similarity. Recombination events between NADC30-like and QYYZ-like PRRSVs have resulted in complex recombination patterns.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Jie Zhang, Juan Bai, Yangyang Sun, Xing Liu, Yanni Gao, Xianwei Wang, Yuanqi Yang, Ping Jiang
Summary: In this study, two strains of PRRSV2 were isolated from clinical samples and their genomic sequences and pathogenicity were analyzed. The results showed that these strains exhibited variations in cell adaption and pathogenic abilities, indicating the diversity of PRRSV strains circulating in China.
MICROBIAL PATHOGENESIS
(2022)
Article
Immunology
Hu Xu, Chao Li, Bangjun Gong, Wansheng Li, Zhenyang Guo, Qi Sun, Jing Zhao, Lirun Xiang, Jinhao Li, Yan-Dong Tang, Chaoliang Leng, Qian Wang, Jinmei Peng, Guohui Zhou, Huairan Liu, Tongqing An, Xuehui Cai, Zhi-Jun Tian, Hongliang Zhang
Summary: A new NADC34-like PRRSV strain, LNTZJ1341-2012, was discovered in China in 2020. It was found that the live-attenuated vaccine candidate SD-R can prevent infection with the representative NADC34-like strain LNTZJ1341-2012, indicating that SD-R is a promising vaccine candidate for the swine industry.
Article
Plant Sciences
Jordan T. T. VanderBurgt, Ondre Harper, Christopher P. P. Garnham, Susanne E. E. Kohalmi, Rima Menassa
Summary: This research aimed to display antigenic portions of the M and GP5 proteins on the surface of tobacco mosaic virus-like particles. The modified tobacco mosaic virus coat protein (TMVc) was expressed in Nicotiana benthamiana plants and resulted in self-assembly and surface display of the M-GP5 epitope.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Veterinary Sciences
Giulia D'Annunzio, Fabio Ostanello, Luisa Vera Muscatello, Massimo Orioles, Niccolo Jacumin, Nicola Tommasini, Giorgio Leotti, Andrea Luppi, Luciana Mandrioli, Giuseppe Sarli
Summary: This study examines the impact of Porcine Circovirus type 2 (PCV2) and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) on Porcine Respiratory Disease Complex (PRDC). The results show that PCV2 and PRRSV are the primary infections associated with PRDC in Italy, and co-infections can worsen the pathology. Therefore, selecting appropriate preventive measures is crucial.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
R. R. Rech, D. Gava, M. C. Silva, L. T. Fernandes, V. Haach, J. R. Ciacci-Zanella, R. Schaefer
ZOONOSES AND PUBLIC HEALTH
(2018)
Article
Microbiology
Danielle Gava, Vitor Hugo Balasco Serrao, Lana Teixeira Fernandes, Mauricio Egidio Cantao, Janice Reis Ciacci-Zanella, Nelson Mores, Rejane Schaefer
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2018)
Article
Public, Environmental & Occupational Health
Carine K. Souza, Daiane P. Oldiges, Ana Paula S. Poeta, Itabajara da S. Vaz, Rejane Schaefer, Danielle Gava, Janice R. Ciacci-Zanella, Claudio W. Canal, Luis G. Corbellini
ZOONOSES AND PUBLIC HEALTH
(2019)
Article
Virology
Ancelmo Rabelo de Souza, Marriam Yamin, Danielle Gava, Janice Reis Ciacci Zanella, Maria Silvia Viccari Gatti, Carlos Francisco Sampaio Bonafe, Daniel Ferreira de Lima Neto
Article
Infectious Diseases
Danielle Gava, Luizinho Caron, Rejane Schaefer, Virginia Santiago Silva, Rudi Weiblen, Eduardo Furtado Flores, Marcelo de Lima, Guilherme Zaha Takeda, Janice Reis Ciacci-Zanella
Summary: This study conducted testing on various porcine biological samples in Brazil and found very few samples tested positive for PRRSV antibodies initially, but upon retesting, all samples turned out to be negative, indicating no conclusive evidence of PRRSV infection in these pigs. Further reinforcement of surveillance program is important to prevent the introduction and dissemination of PRRSV in Brazil.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Microbiology
Wiku B. Adisasmito, Salama Almuhairi, Casey Barton Behravesh, Pepe Bilivogui, Salome A. Bukachi, Natalia Casas, Natalia Cediel Becerra, Dominique F. Charron, Abhishek Chaudhary, Janice R. Ciacci Zanella, Andrew A. Cunningham, Osman Dar, Nitish Debnath, Baptiste Dungu, Elmoubasher Farag, George F. Gao, David T. S. Hayman, Margaret Khaitsa, Marion P. G. Koopmans, Catherine Machalaba, John S. Mackenzie, Wanda Markotter, Thomas C. Mettenleiter, Serge Morand, Vyacheslav Smolenskiy, Lei Zhou
Editorial Material
Medicine, General & Internal
Catherine Machalaba, Wiku B. Adisasmito, Salama Almuhairi, Casey Barton Behravesh, Pepe Bilivogui, Salome A. Bukachi, Natalia Casas, Natalia Cediel Becerra, Dominique F. Charron, Abhishek Chaudhary, Janice R. Ciacci Zanella, Andrew A. Cunningham, Osman Dar, Nitish Debnath, Baptiste Dungu, Elmoubasher Farag, George F. Gao, David T. S. Hayman, Margaret Khaitsa, Marion P. G. Koopmans, John S. Mackenzie, Wanda Markotter, Thomas Mettenleiter, Serge Morand, Vyacheslav Smolenskiy, Lei Zhou, One Hlth High Level Expert Panel
Article
Microbiology
Alexey Markin, Giovana Ciacci Zanella, Zebulun W. Arendsee, Jianqiang Zhang, Karen M. Krueger, Phillip C. Gauger, Amy L. Vincent L. Baker, Tavis K. Anderson
Summary: Research reveals that the 2009 H1N1 influenza virus has the ability to cross species barriers and frequently spread between humans and swine. The virus undergoes genetic and antigenic changes in swine populations, posing a zoonotic threat to humans. The study confirms a correlation between human and swine cases of H1N1 influenza, and the burden of the virus in humans directly impacts its detection in pigs. Additionally, it was found that the persistence of the virus in swine is mainly due to spillovers from human-to-swine transmission. These findings underscore the risk of influenza transmission between humans and swine.
Article
Agriculture, Multidisciplinary
Martin de Marco, Marcelo Miele, Leticia dos Santos Lopes, Paulo Mafra de Almeida Costa, Jefferson de Santana Jacob, Janice Reis Ciacci Zanella
Summary: The objective of this study was to develop an index of adequacy to minimum biosecurity conditions (IAB) to assess the external biosecurity level of pig farms in Brazil. A questionnaire was used to survey pig farms registered in the database of Companhia Integrada de Desenvolvimento Agricola de Santa Catarina, with questions on farm identification, production system, relationship with the agroindustry, herd size, and external biosecurity. The IAB was calculated based on the presence, partial presence, or absence of biosecurity practices, with investments needed for ideal biosecurity practices estimated. The results showed that a significant portion of pig farms had a good external biosecurity level.
PESQUISA AGROPECUARIA BRASILEIRA
(2023)
Article
Biochemistry & Molecular Biology
J. S. G. Rieger, C. Mantovani, P. A. P. Suniga, I. B. Pinto, G. A. A. Sousa, D. Gava, M. E. Cantao, L. R. Santos, F. R. Araujo, J. R. Ciacci-Zanella
Summary: In this study, the VP2 structural protein of SVA was produced and used to develop an indirect ELISA method to detect SVA antibodies in Brazilian swine herds. The rVP2 ELISA showed 100% specificity and 74.4% sensitivity, with 100% sensitivity during the SVA outbreak and 73.4% sensitivity nine months after the outbreak.
GENETICS AND MOLECULAR RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
Malcom Vinicios Ferreira, Danielle Gava, Rejane Schaefer, Ricardo Luis Pierozan, Janice Reis Ciacci Zanella
Summary: The objective of this study was to assess the infection and incidence of influenza A virus (IAV) subtypes in pig nurseries in Santa Catarina, Brazil. Sampled nursery pigs (n=423) from 11 farms were tested for IAV circulation, viral RNA, and antibodies. RT-qPCR was used to detect viral RNA in nasal swab samples (70.2%) and subtype 33 viruses. ELISA detected IAV antibodies (68%), with higher prevalence for H3N2 virus (38.0%), followed by H1N1pdm (23.8%) and H1N2 (3.23%).
PESQUISA AGROPECUARIA BRASILEIRA
(2022)
Article
Agriculture, Dairy & Animal Science
Luiz Carlos Bordin, Danielle Gava, Karina Sonalio, Marina Lopes Mechler-Dreibi, Janice Reis Ciacci Zanella, Nelson Mores, Luis Guilherme de Oliveira, Eliana Knackfuss Vaz
Summary: This study revealed a high prevalence of PHMs among sows in Brazilian pig farms, but the exact impact of the disease on reproductive issues remains unclear.
VETERINARY AND ANIMAL SCIENCE
(2021)
Article
Veterinary Sciences
Dahianne Leia Becker, Janice Reis Ciacci Zanella, Luis Gustavo Corbellini, Mauro Riegert Borba
ACTA SCIENTIAE VETERINARIAE
(2020)
Article
Medicine, General & Internal
Jorge Gilmar Amaral de Oliveira, Vanessa Bonfada, Michele Ferraz Figueiro, Tatiana Mugnol, Janice de Fatima Pavan Zanella, Janaina Coser
Meeting Abstract
Agriculture, Dairy & Animal Science
J. Ciacci-Zanella
JOURNAL OF ANIMAL SCIENCE
(2018)