Article
Dermatology
Jiaqi Zeng, Di Wang, Jialiang Luo, Lei Li, Luyang Lin, Jingyi Li, Wen Zheng, Daming Zuo, Bin Yang
Summary: This study found that the level of MBL is elevated in patients with psoriasis and is positively correlated with disease severity and pDC frequency. In vitro experiments showed that MBL protein can promote the differentiation of pDC and increase the production of inflammatory cytokines and chemokines. Mice deficient in MBL showed reduced accumulation of pDC and decreased secretion of pDC-related cytokines in the early stage of psoriasis. Mechanistic research indicated that the STAT3-IRF8 axis is responsible for MBL-modulated pDC differentiation.
JOURNAL OF DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Meiling Zheng, Zhi Hu, Xiaole Mei, Lianlian Ouyang, Yang Song, Wenhui Zhou, Yi Kong, Ruifang Wu, Shijia Rao, Hai Long, Wei Shi, Hui Jing, Shuang Lu, Haijing Wu, Sujie Jia, Qianjin Lu, Ming Zhao
Summary: This study compares the differences between cutaneous lesions from DLE and SLE patients and healthy controls using single-cell RNA sequencing data. The findings reveal differential immune cell recruitment, cell type, and gene expression, highlighting potential therapeutic targets for lupus erythematosus.
NATURE COMMUNICATIONS
(2022)
Article
Virology
Thi Thu Phuong Tran, Tuan Hiep Tran, Eric J. Kremer
Summary: Most adults develop long-lived B- and T-cell responses after exposure to various human adenoviruses (HAdVs), protecting them from re-infections by the same HAdV type. However, certain HAdV types may lead to persistent infections, especially when an individual's T-cell response is compromised. Interestingly, patients with B-cell deficiencies do not seem to be at a greater risk of HAdV disease.
Article
Immunology
Sofi Damjanovska, Carson Smith, Ismail Sayin, Christopher J. Burant, Stefan Gravenstein, David H. Canaday
Summary: This study aimed to determine if IFN-alpha induction in PBMCs exposed to eight different commercial influenza vaccines is a pDC-dependent process mediated through TLR-7 signaling. Multiple vaccines were found to induce IFN-alpha in a TLR-7-dependent fashion, while some lacked this induction. The significance of these differences between vaccines remains unclear, as all approved vaccine formulations offer some degree of protection.
Article
Immunology
Paoline Laurent, Chao Yang, Andre F. Rendeiro, Benjamin E. Nilsson-Payant, Lucia Carrau, Vasuretha Chandar, Yaron Bram, Benjamin R. tenOever, Olivier Elemento, Lionel B. Ivashkiv, Robert E. Schwartz, Franck J. Barrat
Summary: Lung-infiltrating macrophages play a role in the inflammation and lethality of COVID-19, despite not being infected by the virus. Plasmacytoid dendritic cells (pDCs) in the lungs produce interferons (IFN-I) in response to SARS-CoV-2, leading to macrophage activation. This interaction between pDCs and macrophages may contribute to the severity of the disease.
SCIENCE IMMUNOLOGY
(2022)
Article
Immunology
Qiao Zhou, Jayakumar Vadakekolathu, Abdulla Watad, Kassem Sharif, Tobias Russell, Hannah Rowe, Almas Khan, Peter A. Millner, Peter Loughenbury, Abhay Rao, Robert Dunsmuir, Jake Timothy, Giovanni Damiani, Paolo D. M. Pigatto, Piergiorgio Malagoli, Giuseppe Banfi, Yasser M. El-Sherbiny, Charlie Bridgewood, Dennis McGonagle
Summary: The study found a connection between spinal entheseal plasmacytoid dendritic cells and TNF/IFN alpha production in response to microbes, with SARS-CoV-2 infection associated with PsA flares. JAK inhibition can suppress activated entheseal plasmacytoid dendritic Type-1 interferon responses, indicating a novel mechanism of PsA and SpA-related arthropathy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yongnan Li, Yu Xue, Zhangjie Peng, Linlin Zhang
Summary: This article reviews the recent advances in comparative immunology studies in Lophotrochozoa, focusing on immune recognition and effector systems. Hemocytes and coelomocytes are important but understudied players. Comparative genomics studies show that the expansion and functional divergence of immune reorganization systems in Lophotrochozoa is not as homogeneous and simple as previously thought, and there are various molecular mechanisms that generate immune effector diversity. The author argues that the next generation omics tools and genome editing technicism will revolutionize our understanding of innate immune system in a comparative immunology perspective.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Immunology
Kerstin H. Mair, Maria Stadler, Mahsa Adib Razavi, Armin Saalmuller, Wilhelm Gerner
Summary: This study demonstrates the expression and function of NKp46 on porcine plasmacytoid dendritic cells (pDCs). It was found that the majority of porcine pDCs express NKp46 and have an active signaling pathway upon NKp46 triggering, leading to cytokine production. However, unlike NK cells, NKp46 on porcine pDCs does not seem to be involved in cytotoxicity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Nadine Szumilas, Odilia B. J. Corneth, Christian H. K. Lehmann, Heike Schmitt, Svenia Cunz, Jolie G. Cullen, Talyn Chu, Anita Marosan, Attila Mocsai, Vladimir Benes, Dietmar Zehn, Diana Dudziak, Rudi W. Hendriks, Lars Nitschke
Summary: Siglec-H regulates TLR-9-dependent inflammatory responses after virus infections, but not TLR-7 dependent responses. Lack of Siglec-H in pDCs leads to impaired Hck expression and downregulation of chemokine receptor CCR9, affecting pDC function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Matthew J. Wiest, Laurie Baert, Chao Gu, Kevin M. Gayler, Hyoungjun Ham, Laurent Gorvel, Mira T. Keddis, Leroy W. Griffing, Hyemee Joo, Jean-Pierre Gorvel, Daniel D. Billadeau, Robert R. Kane, Sangkon Oh
Summary: This study investigated the mechanisms of cytokine expression mediated by TLR7 in pDCs and found that specific intracellular trafficking pathways can regulate the production of IFN alpha and TNF alpha by pDCs. This has important implications for understanding the pathogenesis of autoimmune diseases and developing potential therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Lorna Leal, Elvira Couto, Sonsoles Sanchez-Palomino, Nuria Climent, Irene Fernandez, Laia Miralles, Yolanda Romero, Tania Gonzalez, Maria Jose Maleno, Blanca Pano, Judit Pich, Carlos Nicolau, Jose Maria Gatell, Montserrat Plana, Felipe Garcia
Summary: The combination of therapeutic vaccine with IFN α-2a was safe and well-tolerated in chronic HIV-1 infected individuals, but had a minimal impact on viral dynamics.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Tong-Yun Wang, Ming-Xia Sun, Hong-Liang Zhang, Gang Wang, Guoqing Zhan, Zhi-Jun Tian, Xue-Hui Cai, Chenhe Su, Yan-Dong Tang
Summary: Innate immunity serves as the initial defense against viral infections, but viruses like PRRSV have evolved various strategies to evade it. PRRSV, a highly destructive virus in the global swine industry, utilizes multiple strategies to avoid porcine innate immune responses. Understanding the evasion mechanisms employed by PRRSV can aid in developing more effective methods to control and eliminate the virus.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Cell Biology
Xuanzhi Zhu, Hanyao Huang, Lei Zhao
Summary: Atherosclerosis is a chronic artery disease, and periodontitis is a risk factor for it. There is a molecular pathological mechanism connecting the two conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Trevor Ung, Nakisha S. Rutledge, Adam M. Weiss, Aaron P. Esser-Kahn, Peter Deak
Summary: This article summarizes the recent advancements in immunology and chemistry in targeted vaccine technology, including cellular targets, methods of targeting, and their effects on immune responses. The relationships between vaccine targets and subsequent adaptive immune responses are crucial for effective vaccine design, potentially leading to more effective, disease-specific vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Wei Si, Hua Liang, Jason Bugno, Qi Xu, Xingchen Ding, Kaiting Yang, Yanbin Fu, Ralph R. Weichselbaum, Xin Zhao, Liangliang Wang
Summary: Our study demonstrates that oral administration of live LGG enhances the antitumour activity of anti-PD-1 immunotherapy by increasing tumour-infiltrating DCs and T cells, and by shifting the gut microbial community towards enrichment in Lactobacillus murinus and Bacteroides uniformis. Mechanistically, LGG induces IFN-beta production via the cGAS/STING/TBK1/IRF7 axis in DCs, highlighting the potential of LGG as a combination agent with ICB for cancer therapies.
Review
Immunology
Crystal L. Loving, Fernando A. Osorio, Michael P. Murtaugh, Federico A. Zuckermann
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2015)
Article
Virology
Basavaraj Binjawadagi, Yashavanth Shaan Lakshmanappa, Zhu Longchao, Santosh Dhakal, Jagadish Hiremath, Kang Ouyang, Duan-Liang Shyu, Jesus Arcos, Shang Pengcheng, Aaron Gilbertie, Federico Zuckermann, Jordi B. Torrelles, Daral Jackwood, Ying Fang, Gourapura J. Renukaradhya
ARCHIVES OF VIROLOGY
(2016)
Article
Education, Scientific Disciplines
Jonathan H. Foreman, Dawn E. Morin, Thomas K. Graves, Mark A. Mitchell, Federico A. Zuckermann, Herbert E. Whiteley
JOURNAL OF VETERINARY MEDICAL EDUCATION
(2017)
Article
Virology
Wei-Yu Chen, William M. Schniztlein, Gabriela Calzada-Nova, Federico A. Zuckermann
JOURNAL OF VIROLOGY
(2018)
Article
Virology
Gabriela Calzada-Nova, William M. Schnitzlein, Robert J. Husmann, Federico A. Zuckermann
JOURNAL OF VIROLOGY
(2011)
Article
Multidisciplinary Sciences
Debra J. Thomas, Robert J. Husmann, Mauricio Villamar, Timothy R. Winship, Rachael H. Buck, Federico A. Zuckermann
Article
Immunology
Jennifer A. Landolfi, Michele Miller, Carol Maddox, Federico Zuckermann, Jennifer N. Langan, Karen A. Terio
Article
Immunology
Steven Lawson, Joan Lunney, Federico Zuckermann, Fernando Osorio, Eric Nelson, Craig Welbon, Travis Clement, Ying Fang, Susan Wong, Karen Kulas, Jane Christopher-Hennings
Article
Immunology
Gabriela Calzada-Nova, Robert J. Husmann, William M. Schnitzlein, Federico A. Zuckermann
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2012)
Article
Virology
Yijun Du, Federico A. Zuckermann, Dongwan Yoo
Article
Virology
Rajeshwari Parida, In-Soo Choi, Daniel A. Peterson, Asit K. Pattnaik, William Laegreid, Federico A. Zuckermann, Fernando A. Osorio
Article
Virology
David Benfield, Joan K. Lunney, Michael Murtaugh, Eric Nelson, Fernando Osorio, Roman Pogranichniy, Sheela Ramamoorthy, Raymond R. R. Rowland, Jeffrey J. Zimmerman, Federico A. Zuckermann
Article
Immunology
Federico A. Zuckermann, Robert Husmann, WeiYu Chen, Patrick Roady, Janice Pfeiff, Kyle R. Leistikow, Megan Duersteler, Sona Son, Michael R. King, Nathan R. Augspurger
Summary: This study found that providing pigs with a Bacillus-based direct-fed microbial can reduce bacterial colonization in the lungs, eliminate or reduce the presence of the virus, and alleviate lung pathology. Additionally, the DFM also has a systemic modulating effect on innate immunity, enabling it to fight respiratory infections.
INFECTION AND IMMUNITY
(2022)
Article
Immunology
Raquel Portugal, Lynnette C. Goatley, Robert Husmann, Federico A. Zuckermann, Linda K. Dixon
EMERGING MICROBES & INFECTIONS
(2020)