Post transcriptional regulation of PGC-1 alpha can control mitochondrial plasticity thus in turn controlling mitochondrial response to aging. Apparently resveratrol (commonly found in red wine!) leads to increased expression of PGC1alpha thus adding years to your life.
Promising bone metastasis mouse model. Will provide excellent platform to study tumor cellular biology and interactions with immune system. I love how more efficient tumor models are being developed for each specific type of cancer. I hope we find better treatments for metastasis in the near future!
Authors found that increased CSVD burden had significantly decreased circulating CD34+ thus making it a good biomarker for CSVD. The data is impressive.
Mostly in vitro models are used for preclinical radiation oncology but some orthotropic mouse models are also used and are considered better for this research.
Triclosan is used in a plethora of skincare. products and surprisingly enough in unexpected places such as cutting boards and kids' toys. This overexposure to triclosan has been linked to thyroid issues. Looking forward to future steps/research to curb this issue.
Interesting article! How the child did not develop CAH even after prenatal diagnosis of cyp21a2 mutation. Apparently, trimodular haplotype is the reason where there are two wt copies of the gene, one being normal and the other being mutated indicating that better genetic analysis is required to avoid further investigating in such cases.
C. difficile is a growing concern in healthcare/clinical settings even after following required cleaning procedures in certain places. Eradicating C. difficile will definitely require more than bleach. This article mentions a mix of 6 naturally occurring bacteria that have successfully eradicated C. difficile in mice. Hopefully, this will translate well into clinical trials as well.
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