This book is recommended for both
early-career and experienced researchers
and specialists, being extremely useful for
graduate students to aid in understanding the fundamentals in molecular biology and mechanisms of oxidative and ER
stresses, while also being a resource for
the development of new findings in nanomedication and innovative therapies.
As a result of recent advances in nanofabrication, there is an extensive application pallet of nanomaterials in industry,
consumer products, and medicine, which
raises serious concerns regarding the potential toxicity of nanoparticles in humans by
generating reactive radicals. Both oxidative and ER stress parameters are analyzed
in connection with improvement-testing
strategies for aligning nanomaterial safety
assessment and oxidative stress responses.
The final goal is to highlight the correlation
between the roles of antioxidant therapeutic defenses toward redox biology and regulation of immune responses. The book is
generously illustrated with figures and diagrams and closes with general conclusions
and future perspectives.
introduction, and explanatory and development sections. A vast list of updated references is included as well.
Each chapter is self-contained, causing repetition in some concepts, definitions, and explanations. The author
clearly explains the oxidative stress by
the imbalance produced between antioxidants and radical oxygen species (ROS)
actions, either by depletion of antioxidants or accumulation of ROS. However,
recent research reported in this book has
shown that ROS are not simply detrimental because of their high reactivity causing oxidative stress, but they also play an
important regulator role in many physiological and pathophysiological redox processes. ROS production can interfere with
microbe and virus elimination through various mechanisms, but also could contribute
to increasing pathogen burden as occurs in
autoimmune inflammation, causing tissue
damage. These findings offer perspectives
for the use of antioxidants against particular infections
This book is a reference work focused on
the role and interactions of nanoparticles and free radicals that are responsible for
oxidative and endoplasmic reticulum (ER)
stresses, with deep insights into the intimate
mechanisms of their ecotoxicology, cytotoxicity, nanotoxicity, and genotoxicity.
The rapid development of nanoscience
and nanotechnologies and their intersections with biological sciences during the
21st century has resulted in an explosion of
information produced by numerous interand multidisciplinary research projects on
nanomedicine. These are directed toward
understanding topics such as nano-biointeractions caused by nanoparticles with
beneficial or adverse effects on the environment and human health. The author
has organized the scientific sources to be
accessible and useful. In this respect, the
book is structured into 13 chapters as a collection of scientific review papers, each of
which contains a short abstract, keywords,
About the author (2020)
Prof. LOUTFY H. MADKOUR: (Egyptian) has been a Professor of Physical Chemistry, Nano Science and Nanotechnology at Chemistry Department, Faculty of Science and Arts, Al Baha University, Baljarashi, 65635, Saudi Arabia (KSA), since 2012 till now.
He received his B.Sc., M.Sc. and Ph.D. from the Cairo, Minia and Tanta Universities of the AR Egypt, respectively in Physical Chemistry. He worked as a lecturer chemistry at the Tanta University since 1982 and as a professor of physical chemistry in 1999. He has conducted a series of studies in the field of physical chemistry in the field of electrochemistry, corrosion science, density functional theory, molecular dynamic simulation, quantum, theoretical chemistry, chemical equalization principles, nanoscience, nanotechnology, Nano medicine; electrometallurgy, electroanalytical chemistry, analytical chemistry, polarography, electrolytic extraction of heavy metals from natural ores and deposits, electrochemical thermodynamics and environmental chemistry. His earlier research accomplishments include Biosynthesis of Metallic Nanoparticles (MNPs)s and toxicology studies for Pharmacological applications in medicine and therapy. He has published 150 peer-reviewed original research articles, 11 review articles, and 6 books in the area of physical chemistry, practical and applied chemistry, corrosion science, Nanoscience and Nano medicine. He is serving in different positions in Egypt, Kuwait, Yemen, and Saudi Arabia.
Prof. MADKOUR is appointed as the prestigious Editorial Board member of several international journals such as: International Journal of Industrial Chemistry (IJIC) Published by the SPRINGER; International Journal of Ground Sediment & Water; E-Cronicon Chemistry (EC Chemistry); BAOJ Chemistry; Global Drugs and Therapeutics (GDT); Chronicles of Pharmaceutical Science (ISSN 2572-7761) journal; Journal of Targeted Drug Delivery. UNIQUE PUB INTERNATIONAL UPI Journal of Pharmaceutical, Medical and Health Sciences; and Global Journal of Nanomedicine (GJN) ISSN: 2573-2374; Research and Reviews in Computational Chemistry Journal and Journal of Pharmaceutical sciences-current research (JPSCR) in the area of Pharmaceutical, Pharmacology, Journal of Pharmacology & Pharmaceutical Research (JPPR); Archives of Pharmacy & Pharmacology Research journal- APPR and Drug Designing & Development (NAPDD) website; the Pharmaceutical Sciences & Analytical Research Journal (PSARJ); Nanotechnology & Applications (NTA); the Clinical Pharmacology and Toxicology Research; The Laboratory Medicine Journal; Journal Drug Design Development & Therapy MEDCRAVEONLINE.COM MOJDDT; Journal of Pharmacy and Drug Development. E Scientific Publishers and ADVANCES AND APPLICATIONS OF PHARMACY Journal published online by MDPI quarterly. He has joined as an Editorial Board member in Journal of Clinical and Medical Research; International Journal of Environmental Chemistry, Science PG Publishing Group and LOJ Pharmacology & Clinical Research (LOJPCR). He has been uploaded as the Editorial Board member in CPQ MEDICINE (CPQME) Journal and Japan Journal of Research. He has been uploaded as the Editorial Board member in Organic & Medicinal Chemistry International Journal (OMCIJ).
Springer International Publishing, Jan 12, 2020 - Technology & Engineering - 696 pages
This book provides insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. It presents the recent advances in new nanomedication technologies of the effects of nanoparticles NPs on oxidative stress, RONS and ER stress. The book comprises 13 chapters covering ecotoxicology, cytotoxicity, nanotoxicity and genotoxicity mechanisms causing by the role and interactions of nanoparticles and free radicals with (RONS) and (ER) stress. Endoplasmic Reticulum (ER) Stress as a mechanism for NPs induced toxicity has been discussed. The advances of nanotechnology and the effects of nanoparticles on oxidative stress, ROS and ER stress parameters are discussed. Antioxidants, therapeutic options and regulation of the immune responses are explained throughout the book.
Key Features
Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery
Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations
Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy
This book provides a brief summary of heavy metals homeostasis, their environmental
occurrence, its production, and their potential for human exposure, molecular mechanisms of
toxicity, genotoxicity, and carcinogenicity and followed by a description of the available evidence
for their link with CVD. The proposed mechanisms of action by which their toxic effects might be
explained. Xenobiotic heavy metals (Pb, As, Hg and Cd) deplete glutathione and protein-bound
sulfhydryl groups, resulting in the production of reactive oxygen species (ROS) as superoxide ion, hydrogen peroxide and hydroxyl radical (1O2, O2
, H2O2, OH, OH), consequence, enhanced
lipid peroxidation and DNA damage.
The mobilization of heavy metals by man through extraction from ores and processing for
different applications has led to the release of these elements into the environment. Since heavy
metals are non-biodegradable, they accumulate in the environment and subsequently contaminate
the food chain. This contamination poses a risk to environmental and human health. Heavy metals
are strongly implicated in atherosclerotic heart disease. There is many evidence supporting toxic
xenobiotic heavy metals as an emerging cardiovascular risk factor.
Heavy metals are naturally occurring elements that have a high atomic weight and a density at
least 5 times greater than that of water. Toxic xenobiotic metal contamination is linked to
atherosclerotic disease, involved in clogging the arteries, leading to heart attacks, strokes, and other
CVD events and is a modifiable risk factor. Arsenic, cadmium, chromium, lead, and mercury are
considered systemic toxicants that are known to induce multiple organ damage, even at lower levels
of exposure.
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