In vivo models resemble human conditions to a certain extent...but there is a reason why the majority still fail in clinical trials...as they say 'mice are not tiny people'.
I like the website layout. All the issues from 1985 to 2016 are listed on the front page of the website which makes it so easy to browse! nothing after 2016 though...
This article states that menopause contributes to an increased risk of cardiovascular disease in aging women...apparently, menopausal hormone therapy is currently the only preventative option for healthy women at midlife.
According to this research paper, "follow-up testing with computed tomography and carcinoembryonic antigen more frequently compared with less frequently did not result in a significant rate reduction in 5-year overall mortality"...while the research results are clear, I wonder if a long term study will reveal different outcome and if testing more frequently makes the patients feel more at ease and less worried about recurrence...
An interesting finding in CT26 bearing BALB/c mice demonstrates that excessive td-TGF beta renders the tumor non-proliferative...TGF beta is traditionally targeted to suppress cancer, this article debates anti-immunity vs anti-tumor effects of TGF beta.
Melatonin production is the body's natural defense mechanism against UV-induced DNA damage. This article discusses the idea of 'melanin-imitating nanoparticles' that will be very useful for people lacking natural melatonin production due to skin conditions like albinism and vitiligo.
The given link to the above article doesn't seem to work. Here is the link: https://www.scientificamerican.com/article/synthetic-ldquo-melanin-rdquo-could-act-as-a-natural-sunscreen/
mAbs cocktail developed by Regeneron and Eli lily was the first to get FDA emergency use approval before Pfizer and Moderna jumped in with mRNA covid vaccines!
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