Expanding the scope of enzymatic carboligation reactions in flow-mode: production of optically active tertiary alcohols with packed-bed micro-bioreactors

A chiral organocatalytic polymer-based monolithic reactor

(2014) Valerio Chiroli et al.   GREEN CHEMISTRY

Stereoselective DielsAlder Reactions Promoted under Continuous-Flow Conditions by Silica-Supported Chiral Organocatalysts

(2014) Riccardo Porta et al.   ISRAEL JOURNAL OF CHEMISTRY

Combined batch and continuous flow procedure to the chemo-enzymatic synthesis of biaryl moiety of Odanacatib

(2014) Raquel de Oliveira Lopes et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Asymmetric Carbon-Carbon Bond Formation under Continuous-Flow Conditions with Chiral Heterogeneous Catalysts

(2013) Tetsu Tsubogo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A View Through Novel Process Windows

(2013) Stefan C. Stouten et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

A combined continuous microflow photochemistry and asymmetric organocatalysis approach for the enantioselective synthesis of tetrahydroquinolines

(2013) Erli Sugiono et al.   Beilstein Journal of Organic Chemistry

Single Operation Stereoselective Synthesis ofAerangisLactones: Combining Continuous Flow Hydrogenation and Biocatalysts in a Chemoenzymatic Sequence

(2013) Michael J. Fink et al.   ChemCatChem

“One-pot” fabrication of clickable monoliths for enzyme reactors

(2013) Minghuo Wu et al.   CHEMICAL COMMUNICATIONS

A Combined Kinetic and Thermodynamic Approach for the Interpretation of Continuous-Flow Heterogeneous Catalytic Processes

(2013) Olga Bortolini et al.   CHEMISTRY-A EUROPEAN JOURNAL

Novel Process Windows for Enabling, Accelerating, and Uplifting Flow Chemistry

(2013) Volker Hessel et al.   ChemSusChem

CC bond formation using ThDP-dependent lyases

(2013) Michael Müller et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Tether-Free Immobilized Bifunctional Squaramide Organocatalysts for Batch and Flow Reactions

(2013) György Kardos et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Thiazolium-functionalized polystyrene monolithic microreactors for continuous-flow umpolung catalysis

(2013) Olga Bortolini et al.   GREEN CHEMISTRY

Asymmetric anti-Mannich reactions in continuous flow

(2013) Rafael Martín-Rapún et al.   GREEN CHEMISTRY

Stereoselective organic reactions promoted by immobilized chiral catalysts in continuous flow systems

(2013) Alessandra Puglisi et al.   GREEN CHEMISTRY

Supported ionic liquid-like phases as organocatalysts for the solvent-free cyanosilylation of carbonyl compounds: from batch to continuous flow process

(2013) Sergio Martín et al.   GREEN CHEMISTRY

Characterization and multi-step transketolase-ω-transaminase bioconversions in an immobilized enzyme microreactor (IEMR) with packed tube

(2013) Amanatuzzakiah Abdul Halim et al.   JOURNAL OF BIOTECHNOLOGY

Microfluidic multi-input reactor for biocatalytic synthesis using transketolase

(2013) James Lawrence et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis

(2013) D. Tyler McQuade et al.   JOURNAL OF ORGANIC CHEMISTRY

Flow-through immobilized enzyme reactors based on monoliths: I. Preparation of heterogeneous biocatalysts

(2013) Evgenia G. Vlakh et al.   JOURNAL OF SEPARATION SCIENCE

Continuous Flow, Highly Enantioselective Michael Additions Catalyzed by a PS-Supported Squaramide

(2013) Pinar Kasaplar et al.   ORGANIC LETTERS

Continuous-Flow Stereoselective Organocatalyzed Diels–Alder Reactions in a Chiral Catalytic “Homemade” HPLC Column

(2013) Valerio Chiroli et al.   ORGANIC LETTERS

Continuous Flow Organocatalytic C–H Functionalization and Cross-Dehydrogenative Coupling Reactions: Visible Light Organophotocatalysis for Multicomponent Reactions and C–C, C–P Bond Formations

(2013) Magnus Rueping et al.   ACS Catalysis

Recent Advances in Asymmetric Catalysis in Flow

(2013) Dongbo Zhao et al.   ACS Catalysis

Application of Metal-Based Reagents and Catalysts in Microstructured Flow Devices

(2012) Tamilselvi Chinnusamy et al.   ChemSusChem

Synthesis of Carbohydrates in a Continuous Flow Reactor by Immobilized Phosphatase and Aldolase

(2012) Lara Babich et al.   ChemSusChem

Highly Efficient 1,4-Addition of Aldehydes to Nitroolefins: Organocatalysis in Continuous Flow by Solid-Supported Peptidic Catalysts

(2012) Sándor B. Ötvös et al.   ChemSusChem

A Solid-Supported Organocatalyst for Continuous-Flow Enantioselective Aldol Reactions

(2012) Carles Ayats et al.   ChemSusChem

Enamine Catalysis in Flow with an Immobilized Peptidic Catalyst

(2012) Yukihiro Arakawa et al.   ChemSusChem

Silica-supported 5-(pyrrolidin-2-yl)tetrazole: development of organocatalytic processes from batch to continuous-flow conditions

(2012) Olga Bortolini et al.   GREEN CHEMISTRY

Continuous Flow Synthesis. A Pharma Perspective

(2012) Laia Malet-Sanz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modular microfluidic reactor and inline filtration system for the biocatalytic synthesis of chiral metabolites

(2012) Brian O'Sullivan et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Immobilization of phenylalanine dehydrogenase onto Eupergit CM for the synthesis of (S)-2-amino-4-phenylbutyric acid

(2012) A.L. Ahmad et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Towards a continuous flow environment for lipase-catalyzed reactions

(2012) Ivaldo Itabaiana et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

An enzymatic approach to the synthesis of optically pure (3R)- and (3S)-enantiomers of green tea flavor compound 3-hydroxy-3-methylnonane-2,4-dione

(2012) Olga Bortolini et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Flow-through immobilized enzyme reactors based on monoliths: II. Kinetics study and application

(2012) Evgenia G. Vlakh et al.   JOURNAL OF SEPARATION SCIENCE

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Polystyrene-Supported (2S)-(−)-3-exo-Piperazinoisoborneol: An Efficient Catalyst for the Batch and Continuous Flow Production of Enantiopure Alcohols

(2012) Laura Osorio-Planes et al.   ORGANIC LETTERS

Solid Acids as Heterogeneous Support for Primary Amino Acid-Derived Diamines in Direct Asymmetric Aldol Reactions

(2011) Anneleen L. W. Demuynck et al.   ADVANCED SYNTHESIS & CATALYSIS

Coupled chemo(enzymatic) reactions in continuous flow

(2011) Ruslan Yuryev et al.   Beilstein Journal of Organic Chemistry

Continuous-flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyproline

(2011) Xacobe C Cambeiro et al.   Beilstein Journal of Organic Chemistry

Immobilisation of laccase on Eupergit supports and its application for the removal of endocrine disrupting chemicals in a packed-bed reactor

(2011) L. Lloret et al.   BIODEGRADATION

Immobilization and stability of a Rhizopus oryzae lipase expressed in Pichia pastoris: Comparison between native and recombinant variants

(2011) Marina Guillén et al.   BIOTECHNOLOGY PROGRESS

Heterogeneous Catalytic Hydrogenation Reactions in Continuous-Flow Reactors

(2011) Muhammad Irfan et al.   ChemSusChem

Continuous Flow Enzyme-Catalyzed Polymerization in a Microreactor

(2011) Santanu Kundu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzymatic diastereo- and enantioselective synthesis of α-alkyl-α,β-dihydroxyketones

(2011) Pier Paolo Giovannini et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

IMMOBILIZATION OF OXALATE DECARBOXYLASE TO EUPERGIT AND PROPERTIES OF THE IMMOBILIZED ENZYME

(2011) Rihui Lin et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

α-Diketones as acyl anion equivalents: a non-enzymatic thiamine-promoted route to aldehyde–ketone coupling in PEG400 as recyclable medium

(2011) Olga Bortolini et al.   TETRAHEDRON

Biotransformations in microstructured reactors: more than flowing with the stream?

(2011) Juan M. Bolivar et al.   TRENDS IN BIOTECHNOLOGY

NHC-catalysed, chemoselective crossed-acyloin reactions

(2011) Christopher A. Rose et al.   Chemical Science

The Flow’s the Thing…︁Or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow

(2010) Fernando E. Valera et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Intermolecular Aldehyde-Ketone Cross-Coupling through an Enzymatic Carboligation Reaction

(2010) Patrizia Lehwald et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flow chemistry using milli- and microstructured reactors—From conventional to novel process windows

(2010) Tobias Illg et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Heterogeneous catalytic synthesis using microreactor technology

(2010) Christopher G. Frost et al.   GREEN CHEMISTRY

Miniaturization in Biocatalysis

(2010) Pedro Fernandes   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bacillus stearothermophilus acetylacetoin synthase: A new catalyst for C–C bond formation

(2010) Pier Paolo Giovannini et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Delineating Origins of Stereocontrol in Asymmetric Pd-Catalyzed α-Hydroxylation of 1,3-Ketoesters

(2010) Alexander M. R. Smith et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of l-homophenylalanine with immobilized enzymes

(2010) Min-Chih Yen et al.   PROCESS BIOCHEMISTRY

Toward the optimization of continuous-flow aldol and α-amination reactions by means of proline-functionalized silicon packed-bed microreactors

(2010) Alessandro Massi et al.   TETRAHEDRON LETTERS

Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

(2009) Ian R. Baxendale et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Continuous-Flow Synthesis of Ibuprofen

(2009) Andrew R. Bogdan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric reactions in continuous flow

(2009) Xiao Yin Mak et al.   Beilstein Journal of Organic Chemistry

A Solid-Supported Organocatalyst for Highly Stereoselective, Batch, and Continuous-Flow Mannich Reactions

(2009) Esther Alza et al.   CHEMISTRY-A EUROPEAN JOURNAL

Continuous Biocatalytic Processes

(2009) Nagaraj N. Rao et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Microfluidic Reactor for Continuous Flow Biotransformations with Immobilized Enzymes: the Example of Lactose Hydrolysis by a Hyperthermophilic β_cont;-Glycoside Hydrolase

(2008) M. S. Thomsen et al.   ENGINEERING IN LIFE SCIENCES

Enzymatic enantioselective C-C-bond formation in microreactors

(2007) K. Koch et al.   BIOTECHNOLOGY AND BIOENGINEERING