Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 7, Issue -, Pages 1486-1493Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.7.172
Keywords
alpha-aminoxylation; continuous flow; packed-bed reactors; polystyrene-immobilized catalysts; proline
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Funding
- MICINN [CTQ2008-00947/BQU, CSD2006-0003]
- DIUE [2009SGR623]
- ICIQ Foundation
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The application of polystyrene-immobilized proline-based catalysts in packed-bed reactors for the continuous-flow, direct, enantioselective alpha-aminoxylation of aldehydes is described. The system allows the easy preparation of a series of beta-aminoxy alcohols (after a reductive workup) with excellent optical purity and with an effective catalyst loading of ca. 2.5% (four-fold reduction compared to the batch process) working at residence times of ca. 5 min.
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