Industrial biotechnology—the future of green chemistry?

Sitagliptin Manufacture: A Compelling Tale of Green Chemistry, Process Intensification, and Industrial Asymmetric Catalysis

(2011) Aman A. Desai   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Process considerations for the asymmetric synthesis of chiral amines using transaminases

(2011) Pär Tufvesson et al.   BIOTECHNOLOGY AND BIOENGINEERING

Application of Designed Enzymes in Organic Synthesis

(2011) Gernot A. Strohmeier et al.   CHEMICAL REVIEWS

Baeyer−Villiger Monooxygenases: More Than Just Green Chemistry

(2011) Hannes Leisch et al.   CHEMICAL REVIEWS

Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol

(2011) Harry Yim et al.   Nature Chemical Biology

Asymmetric Synthesis of (R)-3-Hydroxy-2-methylpropanoate (‘Roche Ester’) and Derivatives via Biocatalytic CC-Bond Reduction

(2010) Clemens Stueckler et al.   ADVANCED SYNTHESIS & CATALYSIS

Factors Determining the Selection of Organic Reactions by Medicinal Chemists and the Use of These Reactions in Arrays (Small Focused Libraries)

(2010) Tony W. J. Cooper et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric reduction of activated alkenes using an enoate reductase from Gluconobacter oxydans

(2010) Nina Richter et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Microbial production of biovanillin

(2010) A. Converti et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Recent Developments in the Application of Baeyer-Villiger Monooxygenases as Biocatalysts

(2010) Gonzalo de Gonzalo et al.   CHEMBIOCHEM

Biocatalytic Reductions and Chemical Versatility of the Old Yellow Enzyme Family of Flavoprotein Oxidoreductases

(2010) Helen S. Toogood et al.   ChemCatChem

Towards preparative-scale, biocatalytic alkene reductions

(2010) Despina J. Bougioukou et al.   CHEMICAL COMMUNICATIONS

Spectrophotometric determination of etamsylate in pharmaceuticals using ferric chloride based on complex formation reactions

(2010) Basavaiah Vinay et al.   Chemical Industry & Chemical Engineering Quarterly

Applied Biotransformations in Green Solvents

(2010) María J. Hernáiz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biotechnological production of bioflavors and functional sugars

(2010) Juliano Lemos Bicas et al.   Food Science and Technology

Biocatalysts by evolution

(2010) Christian Jäckel et al.   CURRENT OPINION IN BIOTECHNOLOGY

Biocatalysis—key to sustainable industrial chemistry

(2010) Roland Wohlgemuth   CURRENT OPINION IN BIOTECHNOLOGY

Practical chiral alcohol manufacture using ketoreductases

(2010) Gjalt W Huisman et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Optimizing non-natural protein function with directed evolution

(2010) Eric M Brustad et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Asymmetric biocatalysis with microbial enzymes and cells

(2010) Roland Wohlgemuth   CURRENT OPINION IN MICROBIOLOGY

Protein engineering of microbial enzymes

(2010) Dominique Böttcher et al.   CURRENT OPINION IN MICROBIOLOGY

Safety of Oseltamivir in Pregnancy

(2010) Barbara Donner et al.   DRUG SAFETY

A chicory cytochrome P450 mono-oxygenase CYP71AV8 for the oxidation of (+)-valencene

(2010) Katarina Cankar et al.   FEBS LETTERS

Biotechnology for the production of essential oils, flavours and volatile isolates. A review.

(2010) Y. Gounaris   FLAVOUR AND FRAGRANCE JOURNAL

Intensification and economic and ecological assessment of a biocatalytic oxyfunctionalization process

(2010) Daniel Kuhn et al.   GREEN CHEMISTRY

Production of Biovanillin by One-Step Biotransformation Using Fungus Pycnoporous cinnabarinus

(2010) Ashwini Tilay et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Monooxygenases as biocatalysts: Classification, mechanistic aspects and biotechnological applications

(2010) D.E. Torres Pazmiño et al.   JOURNAL OF BIOTECHNOLOGY

Enantiomerically Pure Polyheterocyclic Spiro-β-lactams from trans-4-Hydroxy-l-proline

(2010) Giuseppe Cremonesi et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly efficient and stereoselective biosynthesis of (2S,5S)-hexanediol with a dehydrogenase from Saccharomyces cerevisiae

(2010) Marion Müller et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Guidelines and Cost Analysis for Catalyst Production in Biocatalytic Processes

(2010) Pär Tufvesson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Developments in nitrile and amide biotransformation processes

(2010) Harshad Velankar et al.   TRENDS IN BIOTECHNOLOGY

A Novel Semi-biosynthetic Route for Artemisinin Production Using Engineered Substrate-Promiscuous P450BM3

(2009) Jeffrey A. Dietrich et al.   ACS Chemical Biology

Enzymatic Production of l-Menthol by a High Substrate Concentration Tolerable Esterase from Newly Isolated Bacillus subtilis ECU0554

(2009) Gao-Wei Zheng et al.   ADVANCED SYNTHESIS & CATALYSIS

Biotechnological production of enantiopure epoxides by enzymatic kinetic resolution

(2009) Won Jae Choi   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Sustainable biocatalytic synthesis of L-homophenylalanine as pharmaceutical drug precursor

(2009) A.L. Ahmad et al.   BIOTECHNOLOGY ADVANCES

Biotechnology of flavours—the next generation

(2009) Ralf G. Berger   BIOTECHNOLOGY LETTERS

Biocatalytic Routes to Optically Active Amines

(2009) Matthias Höhne et al.   ChemCatChem

Biocatalysis: The Outcast

(2009) Ruslan Yuryev et al.   ChemCatChem

Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes

(2009) Paul R. Ortiz de Montellano   CHEMICAL REVIEWS

Green Chemistry: Principles and Practice

(2009) Paul Anastas et al.   CHEMICAL SOCIETY REVIEWS

Lonza: Biotechnology – A Key Ingredient for Success in the Future

(2009) Karen T. Robins et al.   CHIMIA

Biocatalysis in development of green pharmaceutical processes

(2009) Junhua Tao et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Baeyer–Villiger monooxygenases: recent advances and future challenges

(2009) Daniel E Torres Pazmiño et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Clinical Application of Incretin-Based Therapy: Therapeutic Potential, Patient Selection and Clinical Use

(2009) David M. Kendall et al.   European Journal of Internal Medicine

Effects of water-miscible ionic liquids on cell growth and nitro reduction using Clostridium sporogenes

(2009) Olutosin Dipeolu et al.   GREEN CHEMISTRY

A green-by-design biocatalytic process for atorvastatin intermediate

(2009) Steven K. Ma et al.   GREEN CHEMISTRY

Conceptual Process Design of Integrated Fermentation, Deacylation, and Crystallization in the Production of β-Lactam Antibiotics

(2009) Carol A. Roa Engel et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Biocatalytic synthesis of atorvastatin intermediates

(2009) Jay M. Patel   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Highly Efficient Asymmetric Synthesis of Sitagliptin

(2009) Karl B. Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Laboratory Evolution of Robust and Enantioselective Baeyer−Villiger Monooxygenases for Asymmetric Catalysis

(2009) Manfred T. Reetz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biotechnological Manufacturing Options for Organic Chemistry

(2009) Hans-Peter Meyer et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

Directed evolution drives the next generation of biocatalysts

(2009) Nicholas J Turner   Nature Chemical Biology

A Continuously Operated Bimembrane Reactor Process for the Biocatalytic Production of (2R,5R)-Hexanediol

(2009) Kirsten Schroer et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of a Practical Biocatalytic Process for (R)-2-Methylpentanol

(2009) Owen W. Gooding et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Highly Enantioselective Reduction of a Small Heterocyclic Ketone: Biocatalytic Reduction of Tetrahydrothiophene-3-one to the Corresponding (R)-Alcohol

(2009) Jack Liang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of a Biocatalytic Process as an Alternative to the (−)-DIP-Cl-Mediated Asymmetric Reduction of a Key Intermediate of Montelukast

(2009) Jack Liang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Efficient Production of Enantiomerically Pure Chiral Amines at Concentrations of 50 g/L Using Transaminases

(2009) Matthew D. Truppo et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants

(2009) Jörg Degenhardt et al.   PHYTOCHEMISTRY

Stereoselective biotransformations using fungi as biocatalysts

(2009) Keyller Bastos Borges et al.   TETRAHEDRON-ASYMMETRY

Asymmetric Synthesis of Optically Pure Pharmacologically Relevant Amines Employing ω-Transaminases

(2008) Dominik Koszelewski et al.   ADVANCED SYNTHESIS & CATALYSIS

Formal Asymmetric Biocatalytic Reductive Amination

(2008) Dominik Koszelewski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NADH Availability Limits Asymmetric Biocatalytic Epoxidation in a Growing Recombinant Escherichia coli Strain

(2008) B. Buhler et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Chemoenzymatic synthesis of the chiral side-chain of statins: application of an alcohol dehydrogenase catalysed ketone reduction on a large scale

(2008) Michael Wolberg et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Directing vanillin production from ferulic acid by increased acetyl-CoA consumption in recombinantEscherichia coli

(2008) Eun-Gyeong Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Developing an industrial artemisinic acid fermentation process to support the cost-effective production of antimalarial artemisinin-based combination therapies

(2008) Jacob R. Lenihan et al.   BIOTECHNOLOGY PROGRESS

Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid

(2008) Dae-Kyun Ro et al.   BMC BIOTECHNOLOGY

E factors, green chemistry and catalysis: an odyssey

(2008) Roger A. Sheldon   CHEMICAL COMMUNICATIONS

Organocatalytic Oxidation. Asymmetric Epoxidation of Olefins Catalyzed by Chiral Ketones and Iminium Salts

(2008) O. Andrea Wong et al.   CHEMICAL REVIEWS

Non-heme iron-dependent dioxygenases: unravelling catalytic mechanisms for complex enzymatic oxidations

(2008) Timothy DH Bugg et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Heme-iron oxygenases: powerful industrial biocatalysts?

(2008) Mattijs K Julsing et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Asymmetric Bioreduction of Activated C=C Bonds UsingZymomonas mobilis NCR Enoate Reductase and Old Yellow Enzymes OYE 1–3 from Yeasts

(2008) Mélanie Hall et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Chemo-enzymatic synthesis of pharmaceutical intermediates

(2008) Ramesh N Patel   Expert Opinion on Drug Discovery

Purification and biochemical characterization of an intracellular lipase byRhizopus chinensisunder solid-state fermentation and its potential application in the production of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)

(2008) Shu Yang Sun et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Preparative scale Baeyer–Villiger biooxidation at high concentration using recombinant Escherichia coli and in situ substrate feeding and product removal process

(2008) Iris Hilker et al.   Nature Protocols

Preparative Asymmetric Synthesis of 4,4-Dimethoxytetrahydro-2H-pyran-3-ol with a Ketone Reductase and in Situ Cofactor Recycling using Glucose Dehydrogenase

(2008) Birgit Kosjek et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The First 200-L Scale Asymmetric Baeyer−Villiger Oxidation Using a Whole-Cell Biocatalyst

(2008) Christopher V. F. Baldwin et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Making artemisinin☆

(2008) Patrick S. Covello   PHYTOCHEMISTRY

New opportunities for biocatalysis: making pharmaceutical processes greener

(2008) John M. Woodley   TRENDS IN BIOTECHNOLOGY

Recent applications of biocatalysis in developing green chemistry for chemical synthesis at the industrial scale

(2007) Ningqing Ran et al.   GREEN CHEMISTRY

Asymmetrical Synthesis of l-Homophenylalanine Using Engineered Escherichia coli Aspartate Aminotransferase

(2005) Hsueh-Hsia Lo et al.   BIOTECHNOLOGY PROGRESS