Review
Cell Biology
Ian James Bell, Matthew Sheldon Horn, Terence John Van Raay
Summary: The non-canonical Wnt signaling pathways have different roles in cancer and development, involving calcium and Vangl2. Cells tend to choose non-canonical Wnt signaling over canonical Wnt signaling when presented with a choice, but this occurs rarely in vivo.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Dakota Doucet, Connor Brubaker, Donald Turner, Carl A. A. Gregory
Summary: Dickkopf-1 (Dkk-1) has a dual role as either a driver or suppressor in tumor growth. The tissue origin of the tumor can predict the role of Dkk-1 in tumor progression. Dkk-1 is more likely to serve as a suppressor in ectodermal and endodermal tumors, while it is more likely to serve as a driver in mesodermal tumors. High Dkk-1 expression is generally associated with poor prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Shiyang Chen, Yajuan Zheng, Xiaojuan Ran, Hui Du, Hua Feng, Lei Yang, Yating Wen, Changdong Lin, Shihui Wang, Mengwen Huang, Zhanjun Yan, Dianqing Wu, Hongyan Wang, Gaoxiang Ge, An Zeng, Yi Arial Zeng, Jianfeng Chen
Summary: T cell contact with intestinal stem cells and transient amplifying cells plays a crucial role in regulating ISC differentiation by influencing the Wnt and Notch signaling pathways through cell-cell signaling. This interaction is essential in maintaining intestinal homeostasis and highlighting the importance of immune cells in intestinal function.
Article
Cell Biology
Natheer Al-Rawi, Muwaffaq Al Ani, Asif Quadri, Zaid Hamdoon, Aktham Awwad, Sausan Al Kawas, Ahmed Al Nuaimi
Summary: The study revealed that the expression of E-cadherin and beta-catenin in oral squamous cell carcinoma is associated with the severity of the tumor and prognosis.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Article
Medicine, Research & Experimental
Shohei Yoshimoto, Hiromitsu Morita, Miho Matsuda, Yoshinori Katakura, Masato Hirata, Shuichi Hashimoto
Summary: This study reveals the molecular mechanism of hyperosmolarity's effect on the development of oral squamous cell carcinoma, with NFAT5 transcription factor and DPAGT1 enzyme playing crucial roles in oral cancer cell proliferation.
LABORATORY INVESTIGATION
(2021)
Article
Cell Biology
Ruiyao Xu, Xianxian Wang, Sadia Safi, Nico Braunegger, Agnes Hipgrave Ederveen, Michelle Rottmann, Joachim Wittbrodt, Manfred Wuhrer, Janine Wesslowski, Gary Davidson
Summary: Reception of Wnt signals is mediated by Frizzled receptors and a co-receptor LRP6 or LRP5. Precise control of receptor activation is crucial to regulate Wnt/beta-catenin signaling for proper cellular function. A glycosyltransferase B3GnT2-like has been identified to modify LRP6 and enhance Wnt/beta-catenin signaling. This study highlights the importance of LRP6 as a regulatory hub in Wnt signaling and provides insight into the selective targeting of a signaling pathway component by a specific glycosyltransferase.
Article
Microbiology
Chongyang Wang, Ruochen Hu, Liuyuan Duan, Qili Hou, Mengqing Yang, Ting Wang, Haijin Liu, Sa Xiao, Ruyi Dang, Juan Wang, Xinglong Wang, Shuxia Zhang, Zengqi Yang
Summary: This study showed that pseudorabies virus (PRV) infection activates the Wnt/beta-catenin signaling pathway, leading to enhanced virus proliferation and regulation of virus-induced autophagy. Inhibitors of this pathway can reduce PRV titers, while stimulation of the pathway can enhance PRV proliferation. These findings provide potential targets for the development of antiviral agents against PRV.
VETERINARY MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qi Zhou, Shengyu Lyu, Anthony A. Bertrand, Allison C. Hu, Candace H. Chan, Xiaoyan Ren, Marley J. Dewey, Aleczandria S. Tiffany, Brendan A. C. Harley, Justine C. Lee
Summary: By comparing noncrosslinked (NX-MC) and crosslinked (MC) forms of MC-GAG, this study evaluated the impact of stiffness on osteogenicity, finding that increasing stiffness can induce osteogenic differentiation through YAP/TAZ and the canonical Wnt signaling pathway, while activation of the canonical BMPR signaling pathway is independent of stiffness.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Oncology
Sangeeta Ghuwalewala, Dishari Ghatak, Sumit Das, Stuti Roy, Pijush Das, Ramesh Butti, Mahadeo Gorain, Somsubhra Nath, Gopal C. Kundu, Susanta Roychoudhury
Summary: The study found an elevated expression of miR-146a in the CD44(high)CD24(low) population within OSCC cells and primary HNSCC tumors. Over-expression of miR-146a enhances stemness phenotype by stabilizing beta-catenin and resulting in loss of E-cadherin and CD24. CD24 is identified as a novel functional target of miR-146a, and mechanistic analysis reveals that higher CD24 levels inhibit AKT phosphorylation leading to beta-catenin degradation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Peripheral Vascular Disease
Irena Kasacka, Zaneta Piotrowska, Natalia Domian, Magdalena Acewicz, Alicja Lewandowska
Summary: The study revealed alterations in Wnt/beta-catenin signaling in the kidneys of rats during hypertension, with the severity of these changes depending on the type of hypertension. This study is the first to assess the levels of some elements of the canonical Wnt/beta-catenin signal transduction pathway in various types of arterial hypertension by immunohistochemistry, and may lead to further molecular and functional studies of this pathway in hypertension.
HYPERTENSION RESEARCH
(2021)
Article
Cell & Tissue Engineering
Ming Chen, Hui Han, Siqi Zhou, Yinxian Wen, Liaobin Chen
Summary: This study demonstrates the ability of Morusin to promote osteogenic differentiation of BMSCs through activation of the Wnt/β-catenin signaling pathway, and suggests the potential of Morusin as a treatment for osteoporosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Jian Song, Nan Jiang, Xueqi Gan, Wei Zhi, Zhuoli Zhu
Summary: The study demonstrated that the local injection of argatroban can rescue bone loss in periodontal disease, while inducing osteogenic differentiation through activating the canonical Wnt signaling pathway. Therefore, argatroban has potential applications in promoting alveolar bone regeneration and remodeling based on BMSCs.
Review
Biochemistry & Molecular Biology
Alexandre Vallee, Yves Lecarpentier, Jean-Noel Vallee
Summary: Glaucoma is a progressive neurodegenerative disease with oxidative stress, inflammation, and glutamatergic pathway playing key roles. CBD, a non-psychotomimetic phytocannabinoid, has shown potential therapeutic effects on glaucoma by increasing the WNT/beta-catenin pathway and reducing GSK-3 beta activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Quan-Wen Liu, Yan-Min Ying, Jia-Xin Zhou, Wen-Jie Zhang, Zhao-Xiao Liu, Bing-Bing Jia, Hao-Cheng Gu, Chu-Yu Zhao, Xiao-Hui Guan, Ke-Yu Deng, Hong-Bo Xin
Summary: This study demonstrated that human amniotic mesenchymal stem cells (hAMSCs) attenuated liver fibrosis by inhibiting the activation of hepatic stellate cells (HSCs) through the depression of the Wnt/β-catenin signaling pathway.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Kathleen A. O'Leary, Debra E. Rugowski, Michael P. Shea, Ruth Sullivan, Amy R. Moser, Linda A. Schuler
Summary: Prolactin (PRL) collaborates with Apc(Min/+) to increase tumor incidence and modulate cancer stem cell activity through Notch-driven signals, shedding light on mechanisms whereby PRL elevates risk of breast cancer.
Article
Multidisciplinary Sciences
Marius Surleac, Ilda Czobor Barbu, Simona Paraschiv, Laura Ioana Popa, Irina Gheorghe, Luminita Marutescu, Marcela Popa, Ionela Sarbu, Daniela Talapan, Mihai Nita, Alina Viorica Iancu, Manuela Arbune, Alina Manole, Serban Nicolescu, Oana Sandulescu, Adrian Streinu-Cercel, Dan Otelea, Mariana Carmen Chifiriuc
Article
Multidisciplinary Sciences
Janice L. Walker, Weihao Wang, Edith Lin, Alison Romisher, Meghan P. Bouchie, Brigid Bleaken, A. Sue Menko, Maria A. Kukuruzinska
Summary: The development of ductal structures during branching morphogenesis relies on cellular asymmetries defined by F-actin and ZO-1, with aPKC zeta and ROCK signaling establishing apical-basal polarity of ductal progenitors. Myosin IIB drives duct maturation by localizing to vertices linking apical domains of multiple ductal epithelial cells.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Laura Ioana Popa, Irina Gheorghe, Ilda Czobor Barbu, Marius Surleac, Simona Paraschiv, Luminita Marutescu, Marcela Popa, Gratiela Gradisteanu Pircalabioru, Daniela Talapan, Mihai Nita, Anca Streinu-Cercel, Adrian Streinu-Cercel, Dan Otelea, Mariana Carmen Chifiriuc
Summary: This study confirmed the transmission of a multi-drug resistant Klebsiella pneumoniae ST101 clone from hospital to wastewater, and its persistence after chlorine treatment. This raises the risk of surface water contamination and further dissemination to different components of the trophic chain, including humans.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Stefania Gheorghe, Daniel N. Mitroi, Miruna S. Stan, Cristina A. Staicu, Marius Cicirma, Irina E. Lucaciu, Mihai Nita-Lazar, Anca Dinischiotu
APPLIED SCIENCES-BASEL
(2020)
Article
Green & Sustainable Science & Technology
Alina R. Banciu, Daniela L. Ionica, Monica A. Vaideanu, Dragos M. Radulescu, Mihai Nita-Lazar, Cristina I. Covaliu
Summary: This study analyzed the microbiological contamination and antibiotic-resistant profile of the St. Gheorghe branch of the Danube Delta influenced by climate change, revealing an increasing trend in bacterial concentration in surface water, correlated with global warming.
Article
Chemistry, Physical
Oana Stoian, Cristina Ileana Covaliu, Gigel Paraschiv, Gina-Alina Catrina (Traistaru), Mihai Nita-Lazar, Ecaterina Matei, Sorin Stefan Biris, Paula Tudor
Summary: This article presents a nonconventional method using magnetite nanomaterial for efficient removal of lead ions from industrial wastewater. The experimental results show that the efficiency is highest at pH 6, impacted by both lower and higher pH values. Langmuir and Freundlich models were used to describe the adsorption process.
Article
Multidisciplinary Sciences
Ariana Dela Cruz, Vinay Kartha, Andrew Tilston-Lunel, Rongjuan Mi, Taylor L. Reynolds, Michael Mingueneau, Stefano Monti, Janicke L. Jensen, Kathrine Skarstein, Xaralabos Varelas, Maria A. Kukuruzinska
Summary: Sjogren's syndrome is a complex autoimmune disease associated with lymphocytic infiltration and secretory dysfunction of salivary and lacrimal glands. Molecular changes in damaged salivary epithelia of SS patients may offer insights into the signals contributing to SS development and progression.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Florentina Laura Chiriac, Catalina Stoica, Roxana-Elena Scutariu, Florinela Pirvu, Iuliana Paun, Vasile Iancu, Toma Galaon, Mihai Nita-Lazar
Summary: This study analyzed the presence, occurrence, and composition of absorbable organic halogens in wastewater and sewage sludge, as well as their genotoxicity effect on the environment. The results showed that the AOX parameter was correlated with the concentration level of volatile organic compounds, chlorophenols, organochlorine pesticides, and polychlorinated biphenyls. The identified halogenated organic compounds accounted for only a small percentage of the total AOX amount, except in dehydrated sludge samples where they accounted for a significant proportion.
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2022)
Article
Environmental Sciences
Stefania Gheorghe, Miruna S. Stan, Daniel N. Mitroi, Andrea C. Staicu, Marius Cicirma, Irina E. Lucaciu, Mihai Nita-Lazar, Anca Dinischiotu
Summary: This study evaluated the acute toxicity of benzethonium chloride (BEC) on the gills and kidneys of European carp. The results showed that BEC induced toxicity in these organs, as evidenced by altered antioxidant enzyme activities, increased lipid peroxidation, and decreased glutathione concentration. Histological observations revealed structural changes, particularly in the gills where the most severe effects were observed.
Article
Environmental Sciences
Cristina F. Alistar, Ionela C. Nica, Mihai Nita-Lazar, Gabriela Geanina Vasile, Stefania Gheorghe, Alexa-Maria Croitoru, Georgiana Dolete, Dan Eduard Mihaiescu, Anton Ficai, Nicolai Craciun, Gratiela Gradisteanu Pircalabioru, Mariana Carmen Chifiriuc, Miruna S. Stan, Anca Dinischiotu
Summary: This study compared the changes in intestine samples of fish collected from different artificial lakes in Bucharest. The results showed that fish from leisure lakes had higher oxidative stress and affected antioxidant enzyme activities, while fish from protected lakes did not have these issues.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
F. L. Chiriac, C. Stoica, I Paun, F. Pirvu, T. Galaon, M. Nita-Lazar
Summary: The presence of organic ultraviolet filters, such as 4-hydroxybenzophenone (4-HBP) and 2,4-dihydroxybenzophenone (BP-1), in the environment poses a threat to aquatic organisms. This study investigated the biodegradation potential of these compounds by different bacterial strains and found that the degradation rates varied among strains. These findings provide important insights into the biodegradation pathways of organic ultraviolet filters.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Art
Iuliana Paun, Daniel Mitru, Cristina Ileana Covaliu, Gigel Paraschiv, Gheorghe Nechifor, Ioana Corina Moga, Alexandru Datcu-Manea, Mihai Nita-Lazar
Summary: Anionic and cationic surfactants are common pollutants that can be biodegraded by microorganisms in wastewater treatment plants. However, some surfactants have low biodegradability, which may have negative effects on water surfaces.
INTERNATIONAL JOURNAL OF CONSERVATION SCIENCE
(2021)
Article
Art
Alina Banciu, Ioana Corina Moga, Ileana Cristina Covaliu, Monica Vaideanu, Dragos Radulescu, Gigel Paraschiv, Alexandru Datcu-Manea, Mihai Nita-Lazar
Summary: The study investigated the adhesion of E. coli on synthetic artificial materials (SAMs) and found that the presence of 7% cellulose in SAMs enhances bacterial adherence.
INTERNATIONAL JOURNAL OF CONSERVATION SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kevin Brown Chandler, Khalid A. Alamoud, Vanessa L. Stahl, Bach-Cuc Nguyen, Vinay K. Kartha, Manish Bais, Kenichi Nomoto, Takashi Owa, Stefano Monti, Maria A. Kukuruzinska, Catherine E. Costello
Article
Chemistry, Multidisciplinary
Mirela Calinescu, Catalina Stoica, Mihai Nita-Lazar
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.