Article
Food Science & Technology
Yijie Yang, Hui Liu, Liyuan Cui, Yibo Liu, Lulu Fu, Bo Li
Summary: This study demonstrated that collagen hydrolysates containing OG peptides have antiplatelet and anti-atherosclerotic activities. Peptide OG-5 inhibits platelet aggregation and tail thrombosis formation by targeting P2Y12 receptors and regulating signaling pathways. It also inhibits the release of inflammatory cytokines and migration of vascular smooth muscle cells. These findings suggest that collagen hydrolysates with OG peptides could be developed as a dietary supplement to prevent atherogenesis and thrombotic disease.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Anders Gottsaeter
Summary: This review focuses on the rationale for recommendations on antiplatelet and anticoagulant treatment in PAD patients, suggesting different medication treatment plans for patients with different symptoms, and the need to weigh the pros and cons based on individual circumstances.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Danusha Michelle Vellasamy, Sin-Jye Lee, Khang Wen Goh, Bey-Hing Goh, Yin-Quan Tang, Long Chiau Ming, Wei Hsum Yap
Summary: Atherosclerosis is a potential cause of cardiovascular diseases, involving immune cells and immune senescence. The secretion of senescence-associated secretory phenotype by senescent cells affects the progress of atherosclerosis. Targeting and clearance of senescent cells emerge as new treatments for atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Seung Hee Lee, Suyeon Cho, Jong Youl Lee, Jung Yeon Hong, Suji Kim, Myong-Ho Jeong, Won-Ho Kim
Summary: Aging is a global problem, with higher prevalence and mortality of arterial and venous thromboembolism (VTE) in the elderly population. This study identifies three specific antithrombotic drug targets through the analysis of platelet proteome in aged mice.
Article
Hematology
Asim Cengiz Akbulut, Ryanne A. Arisz, Constance C. F. M. J. Baaten, Gaukhar Baidildinova, Aarazo Barakzie, Rupert Bauersachs, Jur Ten Berg, Wout W. A. van den Broek, H. C. de Boer, Amandine Bonifay, Vanessa Broker, Richard J. Buka, Hugo ten Cate, Arina J. ten Cate-Hoek, S. Cointe, Ciro De Luca, Ilaria De Simone, Rocio Vacik Diaz, Francoise Dignat-George, Kathleen Freson, Giulia Gazzaniga, Eric C. M. van Gorp, Anxhela Habibi, Yvonne M. C. Henskens, Aaron F. J. Iding, Abdullah Khan, Gijsje H. Koenderink, Akhil Konkoth, Romaric Lacroix, Trisha Lahiri, Wilbur Lam, Rachel E. Lamerton, Roberto Lorusso, Qi Luo, Coen Maas, Owen J. T. McCarty, Paola E. J. van der Meijden, Joost C. M. Meijers, Adarsh K. Mohapatra, Neta Nevo, Alejandro Pallares Robles, Philippe Poncelet, Christoph Reinhardt, Wolfram Ruf, Ronald Saraswat, Claudia Schonichen, Roger Schutgens, Paolo Simioni, Stefano Spada, Henri M. H. Spronk, Karlygash Tazhibayeva, Jecko Thachil, Rocio Vacik Diaz, L. Vallier, Alicia Veninga, Peter Verhamme, Chantal Visser, Steve P. Watson, Philip Wenzel, Ruth A. L. Willems, Anne Willers, Pengyu Zhang, Konstantinos Zifkos, Anton Jan van Zonneveld
Summary: The Fourth Maastricht Consensus Conference on Thrombosis covered a wide range of topics, including the role of coagulation proteins in cardiovascular disease, novel mechanisms of thrombosis, strategies to limit bleeding risks, hemostasis in extracorporeal systems, and clinical dilemmas in thrombosis and antithrombotic management. The conference also revisited the coagulopathy associated with COVID-19.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Physiology
Daniel Carneiro de Carvalho, Francisco Antonio Helfenstein Fonseca, Maria Cristina de Oliveira Izar, Ana Luiza Pereira Assuncao Silveira, Izabela Dorota Tuleta, Jonatas Bussador do Amaral, Lucas Melo Neves, Andre Luis Lacerda Bachi, Carolina Nunes Franca
Summary: This study found that regardless of the treatment received, there was an increase in the number of classical monocytes and a decrease in the number of non-classical monocytes in patients after 6 months of acute myocardial infarction. The percentage of intermediate monocytes was consistently higher. The treatment had no significant effect on the expression of CCR2, CCR5, and CX3CR1 on monocytes. In conclusion, after 6 months of treatment, the inflammatory phenotype of monocytes persisted in the patients.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Henry W. West, Charalambos Antoniades
Summary: Coronary artery disease remains a leading cause of morbidity and mortality globally, with a focus on understanding inflammatory mechanisms driving residual CAD risk. Advances in noninvasive detection of coronary artery inflammation and targeted therapies for inflammation have become critical issues in the field.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Xuelian Li, Xianjie Zhu, Yumiao Wei
Summary: Atherosclerosis is a lipid-driven disease characterized by the imbalance between inflammatory and regressive processes. Recent studies have suggested a link between autophagy and vascular inflammation. This review summarizes the underlying mechanisms associated with different autophagic pathways and NLRP3 inflammasomes in vascular inflammation, aiming to provide additional evidence for atherosclerosis research.
Article
Medicine, General & Internal
Amanda M. Morrison, Alexander E. Sullivan, Aaron W. Aday
Summary: Despite advancements in understanding risk factors and disease interventions, atherosclerosis still affects millions and poses challenges for the healthcare system. Ongoing research aims to identify new risk factors, improve risk calculation, and develop innovative treatments to reduce the burden of atherosclerotic disease. Emerging factors like clonal hematopoiesis and air pollution contribute to cardiovascular risk through inflammation or thrombosis. Genomic advancements offer personalized risk assessment and potential therapeutic interventions through genome editing. Novel drugs like siRNAs show promise in reducing LDL-C or Lp(a) concentrations, with ongoing phase III trials. These areas of research will significantly impact future strategies for atherosclerosis prevention and treatment.
MEDICAL CLINICS OF NORTH AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Chuan-Rong Zhao, Jingyi Li, Zhi-Tong Jiang, Juan-Juan Zhu, Jia-Nan Zhao, Qian-Ru Yang, Weijuan Yao, Wei Pang, Ning Li, Miaorong Yu, Yong Gan, Jing Zhou
Summary: The study demonstrates that disk-shaped nanoparticles have a superior ability to target areas with disturbed blood flow and exhibit better therapeutic effects in treating atherosclerosis compared to spherical nanoparticles.
Review
Pharmacology & Pharmacy
Kawthar Dhayni, Kazem Zibara, Hawra Issa, Said Kamel, Youssef Bennis
Summary: CXCR1 and CXCR2 chemokine receptors are critical in inflammation, and CXCR1/2 inhibitors show beneficial effects in preventing cardiovascular disease progression.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Hematology
Abraham J. P. Teunissen, Mandy M. T. van Leent, Geoffrey Prevot, Eliane E. S. Brechbuhl, Carlos Perez-Medina, Raphael Duivenvoorden, Zahi A. Fayad, Willem J. M. Mulder
Summary: This article explores the role of trained immunity in atherosclerosis and the progress in utilizing nanobiologics for immune therapy targeting myeloid cells. The research demonstrates that nanobiologics have consistent biocompatibility and in vivo behavior across different species.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Ping Ling, Xueying Zheng, Sihui Luo, Junbo Ge, Suowen Xu, Jianping Weng
Summary: ASCVD is the largest cause of morbidity and mortality worldwide, with lipid-lowering therapies as the current major cornerstone of its management. However, some patients do not respond to standard therapies and remain at high risk of ASCVD.
DIABETES OBESITY & METABOLISM
(2021)
Article
Cell Biology
Maan H. Harbi, Christopher W. Smith, Phillip L. R. Nicolson, Steve P. Watson, Mark R. Thomas
Summary: Antiplatelet medications are crucial in treating diseases involving arterial thrombosis, but may cause bleeding and recurrence of thrombotic events. Targeting platelet GPVI and CLEC-2 receptors could offer novel treatment strategies with enhanced antithrombotic efficacy and minimal disruption to hemostasis. Further research into these receptors and their inhibition strategies is needed for effective prevention of platelet recruitment and activation in thrombotic diseases.
Review
Cardiac & Cardiovascular Systems
Christina C. Rolling, Tessa J. Barrett, Jeffrey S. Berger
Summary: Platelets, as vital components in primary hemostasis and thrombosis, have been recognized as important cellular mediators in innate immunity and inflammation. Through forming monocyte-platelet aggregates (MPA) with circulating monocytes, activated platelets have the ability to modulate the phenotype and function of monocytes. The platelet-monocyte axis serves as a crucial link between thrombosis and inflammation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)