Mycobacterium tuberculosis evolutionary pathogenesis and its putative impact on drug development

Targeting Type VII/ESX Secretion Systems for Development of Novel Antimycobacterial Drugs

(2014) Daria Bottai et al.   CURRENT PHARMACEUTICAL DESIGN

Respiratory Outbreak ofMycobacterium abscessusSubspeciesmassiliensein a Lung Transplant and Cystic Fibrosis Center

(2013) Moira L. Aitken et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ESX-1-induced apoptosis is involved in cell-to-cell spread ofMycobacterium tuberculosis

(2013) J. I. Aguilo et al.   CELLULAR MICROBIOLOGY

Vitamin B12 metabolism in Mycobacterium tuberculosis

(2013) Krishnamoorthy Gopinath et al.   Future Microbiology

Progress in targeting cell envelope biogenesis inMycobacterium tuberculosis

(2013) Mary Jackson et al.   Future Microbiology

Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study

(2013) Josephine M Bryant et al.   LANCET

Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistentMycobacterium abscessus

(2013) Alexandre Pawlik et al.   MOLECULAR MICROBIOLOGY

Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA

(2013) Ruben C Hartkoorn et al.   Nature Chemical Biology

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

(2013) Regina Wilson et al.   Nature Chemical Biology

Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans

(2013) Iñaki Comas et al.   NATURE GENETICS

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

(2013) Philip Supply et al.   NATURE GENETICS

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

(2013) Kevin Pethe et al.   NATURE MEDICINE

Advances in the development of new tuberculosis drugs and treatment regimens

(2013) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis

(2013) Thomas R. Ioerger et al.   PLoS One

Whole Genome Sequencing versus Traditional Genotyping for Investigation of a Mycobacterium tuberculosis Outbreak: A Longitudinal Molecular Epidemiological Study

(2013) Andreas Roetzer et al.   PLOS MEDICINE

Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study

(2013) Josephine M Bryant et al.   Lancet Respiratory Medicine

Interferon-gamma release assays for tuberculosis: current and future applications

(2013) Muhunthan Thillai et al.   Expert Review of Respiratory Medicine

SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

(2012) Kapil Tahlan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sterilizing Activities of Novel Combinations Lacking First- and Second-Line Drugs in a Murine Model of Tuberculosis

(2012) Kathy Williams et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ESX-1 dependent impairment of autophagic flux byMycobacterium tuberculosisin human dendritic cells

(2012) Alessandra Romagnoli et al.   Autophagy

Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis

(2012) Timothy M. Chapman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

(2012) Robert O. Watson et al.   CELL

Strong Immunogenicity and Cross-Reactivity of Mycobacterium tuberculosis ESX-5 Type VII Secretion -Encoded PE-PPE Proteins Predicts Vaccine Potential

(2012) Fadel Sayes et al.   Cell Host & Microbe

ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria

(2012) Diane Houben et al.   CELLULAR MICROBIOLOGY

Towards a new tuberculosis drug: pyridomycin - nature's isoniazid

(2012) Ruben C. Hartkoorn et al.   EMBO Molecular Medicine

Inhaled therapies, azithromycin andMycobacterium abscessusin cystic fibrosis patients

(2012) Emilie Catherinot et al.   EUROPEAN RESPIRATORY JOURNAL

New drugs for the treatment of tuberculosis: hope and reality [State of the Art Series. New tools. Number 2 in the series]

(2012) J. H. Grosset et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Mycobacterium abscessus: a new antibiotic nightmare

(2012) R. Nessar et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Acquisition of clarithromycin resistance mutations in the 23S rRNA gene of Mycobacterium abscessus in the presence of inducible erm(41)

(2012) F. P. Maurer et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Long-Range Transcriptional Control of an Operon Necessary for Virulence-Critical ESX-1 Secretion in Mycobacterium tuberculosis

(2012) D. M. Hunt et al.   JOURNAL OF BACTERIOLOGY

MprAB Regulates the espA Operon in Mycobacterium tuberculosis and Modulates ESX-1 Function and Host Cytokine Response

(2012) X. Pang et al.   JOURNAL OF BACTERIOLOGY

Protein Export by the Mycobacterial SecA2 System Is Determined by the Preprotein Mature Domain

(2012) M. E. Feltcher et al.   JOURNAL OF BACTERIOLOGY

Mycobacterium tuberculosisESAT-6 Exhibits a Unique Membrane-interacting Activity That Is Not Found in Its Ortholog from Non-pathogenicMycobacterium smegmatis

(2012) Joaquin De Leon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Composition of the type VII secretion system membrane complex

(2012) Edith N. G. Houben et al.   MOLECULAR MICROBIOLOGY

Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation

(2012) Daria Bottai et al.   MOLECULAR MICROBIOLOGY

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

(2012) Anna E Grzegorzewicz et al.   Nature Chemical Biology

Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis

(2012) Myungsun Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

The ESX-5 Associated eccB5-eccC5 Locus Is Essential for Mycobacterium tuberculosis Viability

(2012) Mariagrazia Di Luca et al.   PLoS One

Para-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis

(2012) S. Chakraborty et al.   SCIENCE

Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death

(2012) Roxane Simeone et al.   PLoS Pathogens

Virulence Regulator EspR of Mycobacterium tuberculosis Is a Nucleoid-Associated Protein

(2012) Benjamin Blasco et al.   PLoS Pathogens

Critical role for NLRP3 in necrotic death triggered by Mycobacterium tuberculosis

(2011) Ka-Wing Wong et al.   CELLULAR MICROBIOLOGY

Activation of the NLRP3 inflammasome byMycobacterium tuberculosisis uncoupled from susceptibility to active tuberculosis

(2011) Anca Dorhoi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Increased Virulence of an Epidemic Strain of Mycobacterium massiliense in Mice

(2011) Shaobin Shang et al.   PLoS One

Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis

(2011) W. Shi et al.   SCIENCE

The rise and fall of the Mycobacterium tuberculosis genome

(2011) Frédéric J. Veyrier et al.   TRENDS IN MICROBIOLOGY

Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

(2011) Kathryn E.A. Lougheed et al.   TUBERCULOSIS

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

Immunotherapy Markedly Increases the Effectiveness of Antimicrobial Therapy for Treatment of Burkholderia pseudomallei Infection

(2010) K. L. Propst et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Sec translocase

(2010) David J.F. du Plessis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome

(2010) Bibhuti B. Mishra et al.   CELLULAR MICROBIOLOGY

Protein export systems ofMycobacterium tuberculosis: novel targets for drug development?

(2010) Meghan E Feltcher et al.   Future Microbiology

The Population Dynamics and Control of Tuberculosis

(2010) C. Dye et al.   SCIENCE

Direct Visualization by Cryo-EM of the Mycobacterial Capsular Layer: A Labile Structure Containing ESX-1-Secreted Proteins

(2010) Musa Sani et al.   PLoS Pathogens

High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling

(2010) Priscille Brodin et al.   PLoS Pathogens

Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants

(2009) Stephen V. Gordon et al.   BIOESSAYS

ESX/type VII secretion systems and their role in host–pathogen interaction

(2009) Roxane Simeone et al.   CURRENT OPINION IN MICROBIOLOGY

Characterization of a Mycobacterium tuberculosis ESX-3 Conditional Mutant: Essentiality and Rescue by Iron and Zinc

(2009) A. Serafini et al.   JOURNAL OF BACTERIOLOGY

Pristinamycin-inducible gene regulation in mycobacteria

(2009) Francesca Forti et al.   JOURNAL OF BIOTECHNOLOGY

Antigen Load Governs the Differential Priming of CD8 T Cells in Response to the Bacille Calmette Guerin Vaccine or Mycobacterium tuberculosis Infection

(2009) A. A. Ryan et al.   JOURNAL OF IMMUNOLOGY

Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families

(2009) Daria Bottai et al.   MOLECULAR MICROBIOLOGY

Synthetic EthR inhibitors boost antituberculous activity of ethionamide

(2009) Nicolas Willand et al.   NATURE MEDICINE

The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

(2009) Andreas H. Diacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Non Mycobacterial Virulence Genes in the Genome of the Emerging Pathogen Mycobacterium abscessus

(2009) Fabienne Ripoll et al.   PLoS One

Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition

(2009) M. S. Siegrist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

(2009) V. Makarov et al.   SCIENCE

High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

(2009) Thierry Christophe et al.   PLoS Pathogens

Systematic Genetic Nomenclature for Type VII Secretion Systems

(2009) Wilbert Bitter et al.   PLoS Pathogens

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

(2008) T. P. Stinear et al.   GENOME RESEARCH

Identification of Functional Tat Signal Sequences in Mycobacterium tuberculosis Proteins

(2008) J. A. McDonough et al.   JOURNAL OF BACTERIOLOGY

Direct Visualization of the Outer Membrane of Mycobacteria and Corynebacteria in Their Native State

(2008) B. Zuber et al.   JOURNAL OF BACTERIOLOGY

Capsular glucan and intracellular glycogen ofMycobacterium tuberculosis: biosynthesis and impact on the persistence in mice

(2008) Tounkang Sambou et al.   MOLECULAR MICROBIOLOGY

Secreted transcription factor controls Mycobacterium tuberculosis virulence

(2008) Sridharan Raghavan et al.   NATURE

Control of M. tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP

(2008) Wafa Frigui et al.   PLoS Pathogens

Disclosure of the mycobacterial outer membrane: Cryo-electron tomography and vitreous sections reveal the lipid bilayer structure

(2008) C. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA