Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs

Inhibition ofLeishmania infantumTrypanothione Reductase by Azole-Based Compounds: a Comparative Analysis with Its Physiological Substrate by X-ray Crystallography

(2013) Paola Baiocco et al.   ChemMedChem

Molecular Dynamics Reveal Binding Mode of Glutathionylspermidine by Trypanothione Synthetase

(2013) Oliver Koch et al.   PLoS One

Targeting Trypanothione Metabolism in Trypanosomatid Human Parasites

(2012) Viridiana Olin-Sandoval et al.   CURRENT DRUG TARGETS

Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation

(2012) P. K. Fyfe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Re-Emergence of Visceral and Cutaneous Leishmaniasis in the Greek Island of Crete

(2012) Vasiliki Christodoulou et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

The Crystal Structures of the Tryparedoxin-Tryparedoxin Peroxidase Couple Unveil the Structural Determinants of Leishmania Detoxification Pathway

(2012) Annarita Fiorillo et al.   PLoS Neglected Tropical Diseases

A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition

(2011) Andrea Ilari et al.   AMINO ACIDS

Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4

(2011) Xi Wang et al.   BIOCHEMICAL JOURNAL

Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani

(2011) Prakash Saudagar et al.   BIOLOGICAL CHEMISTRY

The trypanothione system and the opportunities it offers to create drugs for the neglected kinetoplast diseases

(2011) Leopold Flohé   BIOTECHNOLOGY ADVANCES

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

(2011) Daniel Spinks et al.   ChemMedChem

Crystal Structure of Reduced and of Oxidized Peroxiredoxin IV Enzyme Reveals a Stable Oxidized Decamer and a Non-disulfide-bonded Intermediate in the Catalytic Cycle

(2011) Zhenbo Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

(2011) Stephen Patterson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combining Climatic Projections and Dispersal Ability: A Method for Estimating the Responses of Sandfly Vector Species to Climate Change

(2011) Dominik Fischer et al.   PLoS Neglected Tropical Diseases

Polyamine metabolism in Leishmania: from arginine to trypanothione

(2010) Gianni Colotti et al.   AMINO ACIDS

Education is key to controlling visceral leishmaniasis

(2010)   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities

(2010) Christian Eberle et al.   ChemMedChem

Inhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania infantum Proliferation

(2010) Paola Baiocco et al.   ACS Medicinal Chemistry Letters

Synthesis, Inhibition Potency, Binding Mode, and Antiprotozoal Activities of Fluorescent Inhibitors of Trypanothione Reductase Based on Mepacrine-Conjugated Diaryl Sulfide Scaffolds

(2009) Christian Eberle et al.   ChemMedChem

Investigation of Trypanothione Reductase as a Drug Target inTrypanosoma brucei

(2009) Daniel Spinks et al.   ChemMedChem

Chemical Validation of Trypanothione Synthetase

(2009) Leah S. Torrie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and characterization of a pyridine-2-thiol N-oxide gold(I) complex with potent antiproliferative effect against Trypanosoma cruzi and Leishmania sp. insight into its mechanism of action

(2009) Marisol Vieites et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Molecular Basis of Antimony Treatment in Leishmaniasis†

(2009) Paola Baiocco et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase inTrypanosoma bruceiusing chemical and genetic methods

(2009) Susan Wyllie et al.   MOLECULAR MICROBIOLOGY

Trypanothione Reductase from Leishmania infantum: Cloning, Expression, Purification, Crystallization and Preliminary X-Ray Data Analysis

(2009) Paola Baiocco et al.   PROTEIN AND PEPTIDE LETTERS

Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases

(2008) Magnus S. Alphey et al.   BIOCHEMICAL JOURNAL

Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

(2008) R. Luise Krauth-Siegel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

ProtorP: a protein-protein interaction analysis server

(2008) C. Reynolds et al.   BIOINFORMATICS

ATP-dependent ligases in trypanothione biosynthesis - kinetics of catalysis and inhibition by phosphinic acid pseudopeptides

(2008) Sandra L. Oza et al.   FEBS Journal

The cytosolic tryparedoxin of Leishmania infantum is essential for parasite survival

(2008) Susana Romao et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

LeishmaniaTrypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities

(2008) Paul K. Fyfe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalytic Cycle of Human Glutathione Reductase Near 1 Å Resolution

(2008) Donald S. Berkholz et al.   JOURNAL OF MOLECULAR BIOLOGY

Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities

(2008) Bernhard Stump et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

In vitro evaluation of the effectiveness and cytotoxicity of meglumine antimoniate microspheres produced by spray drying against Leishmania infantum

(2008) G. Pujals et al.   PARASITOLOGY RESEARCH

Clinical pharmacology of gold

(2008) W. F. Kean et al.   INFLAMMOPHARMACOLOGY