Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

(2010) Deuan C. Jones et al.   BIOCHEMICAL PHARMACOLOGY

Investigation of Trypanothione Reductase as a Drug Target inTrypanosoma brucei

(2009) Daniel Spinks et al.   ChemMedChem

Chemical Validation of Trypanothione Synthetase

(2009) Leah S. Torrie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase inTrypanosoma bruceiusing chemical and genetic methods

(2009) Susan Wyllie et al.   MOLECULAR MICROBIOLOGY

ATP-dependent ligases in trypanothione biosynthesis - kinetics of catalysis and inhibition by phosphinic acid pseudopeptides

(2008) Sandra L. Oza et al.   FEBS Journal

LeishmaniaTrypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities

(2008) Paul K. Fyfe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetoplastids: related protozoan pathogens, different diseases

(2008) Ken Stuart et al.   JOURNAL OF CLINICAL INVESTIGATION