Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities

Chagas disease: a new worldwide challenge

(2010) José Rodrigues Coura et al.   NATURE

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

(2009) Stephen Patterson et al.   ChemMedChem

Synthesis, Inhibition Potency, Binding Mode, and Antiprotozoal Activities of Fluorescent Inhibitors of Trypanothione Reductase Based on Mepacrine-Conjugated Diaryl Sulfide Scaffolds

(2009) Christian Eberle et al.   ChemMedChem

Docking and molecular dynamics simulation of quinone compounds with trypanocidal activity

(2009) Fábio Alberto de Molfetta et al.   JOURNAL OF MOLECULAR MODELING

Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi

(2009) Deuan C. Jones et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Pentafluorosulfanyl as a Novel Building Block for Enzyme Inhibitors: Trypanothione Reductase Inhibition and Antiprotozoal Activities of Diarylamines

(2008) Bernhard Stump et al.   CHEMBIOCHEM

Kinetoplastids: related protozoan pathogens, different diseases

(2008) Ken Stuart et al.   JOURNAL OF CLINICAL INVESTIGATION

Regioselective Synthesis of 1-(2,6-Dichloro-4-Trifluoromethylphenyl)- 4-Alkyl-1H-[1,2,3]-Triazoles

(2008) Huanan Hu et al.   MOLECULES

Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities

(2008) Bernhard Stump et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: Synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4′-yl(oyl)] piperazines

(2007) Latifa Boukli et al.   BIOORGANIC & MEDICINAL CHEMISTRY