Advancing cancer drug discovery towards more agile development of targeted combination therapies

Strengthening clinical cancer research in the United Kingdom

(2011) M Stead et al.   BRITISH JOURNAL OF CANCER

Bevacizumab

(2011) Katherine F. Croom et al.   DRUGS

How Genetically Engineered Mouse Tumor Models Provide Insights Into Human Cancers

(2011) Katerina Politi et al.   JOURNAL OF CLINICAL ONCOLOGY

Novel agents combined get own guidance

(2011)   NATURE BIOTECHNOLOGY

Activation of ERBB2 Signaling Causes Resistance to the EGFR-Directed Therapeutic Antibody Cetuximab

(2011) K. Yonesaka et al.   Science Translational Medicine

Live Cell in Vitro and in Vivo Imaging Applications: Accelerating Drug Discovery

(2011) Beverley Isherwood et al.   Pharmaceutics

Identification of Optimal Drug Combinations Targeting Cellular Networks: Integrating Phospho-Proteomics and Computational Network Analysis

(2010) S. Iadevaia et al.   CANCER RESEARCH

Dynamic combinatorial libraries: new opportunities in systems chemistry

(2010) Rosemary A. R. Hunt et al.   CHEMICAL COMMUNICATIONS

Functional Proteomic Analysis of Advanced Serous Ovarian Cancer Using Reverse Phase Protein Array: TGF-  Pathway Signaling Indicates Response to Primary Chemotherapy

(2010) M. S. Carey et al.   CLINICAL CANCER RESEARCH

Intravital microscopy: a novel tool to study cell biology in living animals

(2010) Roberto Weigert et al.   HISTOCHEMISTRY AND CELL BIOLOGY

High-Content Phenotypic Profiling of Drug Response Signatures across Distinct Cancer Cells

(2010) P. D. Caie et al.   MOLECULAR CANCER THERAPEUTICS

Proof of Concept: Network and Systems Biology Approaches Aid in the Discovery of Potent Anticancer Drug Combinations

(2010) A. S. Azmi et al.   MOLECULAR CANCER THERAPEUTICS

Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry

(2010) Venugopal T. Bhat et al.   Nature Chemistry

Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering

(2010) B. G. Saar et al.   SCIENCE

Raman Spectroscopy and Related Techniques in Biomedicine

(2010) Andrew Downes et al.   SENSORS

Use of photoactivation and photobleaching to monitor the dynamic regulation of E-cadherin at the plasma membrane

(2010) Marta Canel et al.   Cell Adhesion & Migration

A Multidimensional Strategy to Detect Polypharmacological Targets in the Absence of Structural and Sequence Homology

(2010) Jacob D. Durrant et al.   PLoS Computational Biology

I-SPY 2: An Adaptive Breast Cancer Trial Design in the Setting of Neoadjuvant Chemotherapy

(2009) AD Barker et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Antibody-based proteomics

(2009) Hans Voshol et al.   FEBS Journal

Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells

(2009) R. G. Zinner et al.   MOLECULAR CANCER THERAPEUTICS

Profiling distinct mechanisms of tumour invasion for drug discovery: imaging adhesion, signalling and matrix turnover

(2008) Neil O. Carragher   CLINICAL & EXPERIMENTAL METASTASIS

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

(2008) Beth Apsel et al.   Nature Chemical Biology

Microscopic imaging techniques for drug discovery

(2007) Andrew Bullen   NATURE REVIEWS DRUG DISCOVERY