Article
Plant Sciences
Muhammad Usman, Syeda Anum Masood Bokhari, Bilquees Fatima, Bushra Rashid, Faisal Nadeem, Muhammad Bilal Sarwar, Muhammad Shah Nawaz-ul-Rehman, Muhammad Shahid, Chaudhary Muhammad Ayub
Summary: This study investigated the morphophysiological responses and transcriptional regulations to drought stress in two guava cultivars. The results showed a decrease in both morphological and physiological attributes under drought stress, but the Surahi cultivar exhibited higher drought tolerance with increased water use efficiency and enzyme activities. The differential expression of ESTs in Surahi cultivar regulated its cellular, biological, and molecular functions, enhancing the morphophysiological attributes against drought stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agronomy
Monica Rojas-Gomez, Jose Pablo Jimenez-Madrigal, Maripaz Montero-Vargas, Randall Loaiza-Montoya, Max Chavarria, Esteban Meneses, Eric J. Fuchs
Summary: Psidium friedrichsthalianum, commonly known as Cas or Costa Rican guava, is a tropical tree species with biological potential. This study presents the first draft assembly of the Cas genome using PacBio long reads, providing a basis for exploring the genetic potential of this functional food crop.
GENETIC RESOURCES AND CROP EVOLUTION
(2022)
Review
Biochemistry & Molecular Biology
Tsvetelina Atanasova, Teodora Stankova, Anelia Bivolarska, Tatyana Vlaykova
Summary: Matrix metalloproteinases (MMPs) are a group of proteolytic enzymes dependent on Ca2+ and Zn2+, which can degrade various components of extracellular matrix (ECM) and other regulatory molecules. The important roles of both MMPs and their endogenous inhibitors, TIPMs, in oral health, tooth development, and enamel maturation have been proven. This mini-review aims to summarize the literature on MMPs functions, with a focus on MMP-8 (collagenase-2 or neutrophil collagenase) in the development and progression of periodontitis, peri-implantitis, and carious lesions. Additionally, we emphasize the role of specific gene variants in MMP8 as predisposing factors for some oral diseases.
Article
Food Science & Technology
Rodrigo Munoz-Arrieta, Daniel Esquivel-Alvarado, Emilia Alfaro-Viquez, Massiel Rodriguez-Salazar, Victor Alvarez-Valverde, Gerardo Rodriguez, Jess D. Reed
Summary: This study provides a detailed description of the nutritional and chemical composition of Costa Rican guava for the first time, including the content of various nutrients and the types of main components.
ACS FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ewa Tomaszewska, Halyna Rudyk, Izabela Swietlicka, Monika Hulas-Stasiak, Janine Donaldson, Marta Arczewska, Siemowit Muszynski, Piotr Dobrowolski, Maria Mielnik-Blaszczak, Marcin Bartlomiej Arciszewski, Volodymyr Kushnir, Oksana Brezvyn, Viktor Muzyka, Ihor Kotsyumbas
Summary: Exposure to fumonisins during pregnancy negatively impacts offspring bone development by altering bone metabolism and affecting the expression of proteins responsible for bone matrix degradation in a dose- and sex-dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Nuralam Sam, Irawan Yusuf, Irfan Idris, Endy Adnan, Ratna Darjanti Haryadi, Firdaus Hamid, Andry Usman, Muhammad Phetrus Johan, Andi Alfian Zainuddin, Agussalim Bukhari
Summary: This study aimed to investigate the effect of prolotherapy on functional outcome improvements in frozen shoulder patients, as well as the ratio of matrix metalloproteinase-1 (MMP-1)/tissue inhibitor matrix metalloproteinase-1 (TIMP-1) as an indicator of tissue repair. The results showed a significant difference in the ratio of MMP-1/TIMP-1 level between the prolotherapy group and the normal saline group at week 6 and week 12. Both groups performed well in terms of the Numerical Rating Scale score and functional outcome. Prolotherapy changed the mean range of motion in flexion and internal rotation compared to the normal saline group.
Article
Cell Biology
Liangjun Jiang, Kunkun Sheng, Cong Wang, Deting Xue, Zhijun Pan
Summary: Recent studies have shown that MMP2-I1 plays a positive role in the osteogenesis of human bone marrow mesenchymal stem cells and angiogenesis of human vascular endothelial cells. It activates signaling pathways to promote osteogenesis and angiogenesis, and has been found to enhance bone formation and prevent bone loss in animal models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
N. Bayar Muluk, O. K. Arikan, P. Atasoy, R. Kilic, E. Tuna Yalcinozan
Summary: This study investigated the role of matrix metalloproteinase-2 (MMP-2) and MMP-9 in the pathogenesis of nasal polyps (NP). The results showed that MMP2 and MMP9 were expressed at higher levels in granulocytes and mast cells compared to monocytes. Additionally, tissue inhibitor of metalloproteinase-1 (TIMP-1) was also expressed at higher levels in mast cells compared to granulocytes and monocytes. Excessive MMP2 and MMP9 in granulocytes and mast cells contribute to the degradation of the extracellular matrix, allowing inflammatory cells to pass through and causing polypoid degeneration.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Barczak, Mirona Palczewska-Komsa, Mariusz Lipski, Dariusz Chlubek, Jadwiga Buczkowska-Radlinska, Irena Baranowska-Bosiacka
Summary: The study investigated the effect of new silicate cement mineral trioxide aggregate (MTA Repair HP) on the inflammation process involving tooth and periodontal tissues. Results showed that the MTA Repair HP did not increase inflammatory response or affect the activity of MMP-2 and MMP-9 in monocytes/macrophages. This suggests that the new material may not interfere with the process of dentin regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Sanja Dimic-Janjic, Mir Alireza Hoda, Branislava Milenkovic, Jelena Kotur-Stevuljevic, Mihailo Stjepanovic, Daniela Gompelmann, Jelena Jankovic, Milica Miljkovic, Jelena Milin-Lazovic, Natasa Djurdjevic, Dragana Maric, Ivan Milivojevic, Spasoje Popevic
Summary: Serum levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) are elevated in patients with chronic obstructive pulmonary disease (COPD), indicating an imbalance between proteases and protease inhibitors. MMP-9 and MMP-9/TIMP-1 ratio are associated with lung function, symptom severity scores, and acute exacerbations.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Clinical Neurology
Jara Carcel-Marquez, Natalia Cullell, Elena Muino, Cristina Gallego-Fabrega, Miquel Lledos, Laura Ibanez, Jerzy Krupinski, Joan Montaner, Carlos Cruchaga, Jin-Moo Lee, Dipender Gill, Guillaume Pare, Marina Mola-Caminal, Jaume Roquer, Jordi Jimenez-Conde, Joan Marti-Fabregas, Israel Fernandez-Cadenas
Summary: The study suggests a causal link between lower serum levels of MMP-12 and the risk of ischemic stroke, lower serum levels of MMP-1 and MMP-12 and the risk of large-artery stroke, and higher serum levels of MMP-8 and the risk of lacunar stroke.
Article
Environmental Sciences
Jacek Kudelski, Grzegorz Mlynarczyk, Monika Gudowska-Sawczuk, Barbara Mroczko, Barbara Darewicz, Marta Bruczko-Goralewska, Lech Romanowicz
Summary: This study evaluated the DNA content, expression, and activity of two enzymes in renal cancer. It was found that the DNA content increased in renal cancer tissues, as did the content of stromelysins. Additionally, the content of stromelysin-2 was higher in high-grade renal cancer tissues, and the activity of both enzymes decreased with increasing cancer grade. These findings suggest a correlation between extracellular matrix degradation and cancer grade.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Taewoo Kim, Jeha Jeon, Jin-Sun Park, Yeongwon Park, Jooeui Kim, Haneul Noh, Hee-Sun Kim, Hyemyung Seo
Summary: In this study, the MMP-8 inhibitor was found to reduce the number of activated microglia and restore cellular atrophy in a PD model, as well as improve motor coordination abnormalities. These findings suggest that MMP-8i attenuates pathological symptoms of PD through anti-inflammatory processes.
BIOMOLECULES & THERAPEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Meagan E. E. Ita, Sagar Singh, Harrison R. R. Troche, Rachel L. L. Welch, Beth A. A. Winkelstein
Summary: Chronic joint pain is a significant healthcare challenge with a large socioeconomic burden. This study investigates the role of MMP-1 in mediating pain in synovial joints and its effects on the collagen network, biomechanical response, and neuronal regulation of the capsular ligament. The findings suggest that MMP-1 may play a crucial role in neuronal signaling in joint pain and that MMP-1 presence in the joint space could lead to altered responses to loading. These findings have implications for the development of new treatments for degenerative joint pain.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Xiao-Wei Zhang, Lin Li, Wen-Qian Hu, Ming-Ning Hu, Yan Tao, Hui Hu, Xiao-Kang Miao, Wen-Le Yang, Qiong Zhu, Ling-Yun Mou
Summary: This study reveals that G protein-coupled receptor neurokinin-1 (NK1R) is significantly upregulated in lung cancer samples and is associated with advanced clinical stages and poor prognosis. NK1R co-expresses with epidermal growth factor receptor (EGFR) and interacts with it in tumor cells. Activation of NK1R promotes lung cancer cell proliferation and migration through EGFR signaling pathways. Inhibition of NK1R suppresses cell proliferation and migration, and knockdown of NK1R slows down tumor growth. The presence of a selective NK1R antagonist enhances the sensitivity of lung cancer cells to specific drugs.
CELL DEATH & DISEASE
(2022)
Article
Agriculture, Multidisciplinary
Da-Ke Zhao, Ya-Na Shi, Vanya Petroya, Grace G. L. Yue, Adam Negrin, Shi-Biao Wu, Jeanine M. D'Armiento, Clara B. S. Lau, Edward J. Kennelly
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Agriculture, Multidisciplinary
Ronghui Gu, Levi Rybalov, Adam Negrin, Taylan Morcol, Weiwen Long, Amanda K. Myers, Giorgis Isaac, Jimmy Yuk, Edward J. Kennelly, Chunlin Long
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Agriculture, Multidisciplinary
Adam Negrin, Chunlin Long, Timothy J. Motley, Edward J. Kennelly
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Agricultural Engineering
Rong-hui Gu, Taylan Morcol, Bo Liu, Min-jie Shi, Edward J. Kennelly, Chun-lin Long
INDUSTRIAL CROPS AND PRODUCTS
(2019)
Article
Biochemistry & Molecular Biology
Yuanyuan Ji, Ruifei Zhang, Chen Zhang, Xingyu Li, Adam Negrin, Chaonan Yuan, Edward J. Kennelly, Chunlin Long
Review
Plant Sciences
Ruifei Zhang, Yuanyuan Ji, Xinbo Zhang, Edward J. Kennelly, Chunlin Long
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Chemistry, Applied
Taylan B. Morcol, Adam Negrin, Paul D. Matthews, Edward J. Kennelly
Article
Chemistry, Medicinal
Yutong Han, Xingyu Li, Chaonan Yuan, Ronghui Gu, Edward J. Kennelly, Chunlin Long
NATURAL PRODUCT COMMUNICATIONS
(2020)
Review
Chemistry, Medicinal
Ruifei Zhang, Qiang Guo, Edward J. Kennelly, Chunlin Long, Xingyun Chai
Article
Chemistry, Applied
Binsheng Luo, Ertan Kastrat, Taylan Morcol, Haiping Cheng, Edward Kennelly, Chunlin Long
Summary: Gaultheria longibracteolata has been traditionally used by different linguistic groups in Yunnan Province, China for various purposes. The essential oil from this plant contains methyl salicylate as the main component (> 90%) and exhibits antimicrobial activity. Further studies are needed to develop it as a natural wintergreen oil substitute.
Article
Environmental Sciences
Jennifer K. Saxe, Stacy Dean, Randy L. Jones, Larry A. Mullins, Kurt A. Reynertson
Summary: Recent legislative measures restricting the sale of sunscreens containing certain UVFs are based on a perceived risk to aquatic life despite the lack of strong data support. Concerns are centered on the potential exposure to corals from sunscreen use by recreational swimmers and divers.
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
(2021)
Article
Chemistry, Applied
Jennifer K. Saxe, Larry Mullins, Randy Jones, Alan Lewis Jr, Frank Sun, Kurt A. Reynertson
Summary: This study investigates the rinse-off of ultraviolet filters (UVFs) from sunscreen products during recreation in seawater. The results show that the potential for sunscreen UVF rinse-off is significantly influenced by formulation type, and the levels of rinse-off are generally lower than previously assumed. Formulation consideration is essential for accurate exposure models used in environmental risk assessment, with anhydrous and reverse phase (water-in-oil) sunscreen formulations resulting in lower UVF transfer to synthetic seawater and expected to yield lower UVF exposures to sea life.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Yong Shen, Wen-Juan Liang, Ya-Na Shi, Edward J. Kennelly, Da-Ke Zhao
NATURAL PRODUCT REPORTS
(2020)
Article
Ecology
Y. Lv, Y. Shen, Y. Shi, F. Shen, Y. Chen, S. Zi, Z. Zhu, E. J. Kennelly, D. Zhao
APPLIED ECOLOGY AND ENVIRONMENTAL RESEARCH
(2019)
Article
Chemistry, Multidisciplinary
Ronghui Gu, Yuehu Wang, Shibiao Wu, Yeling Wang, Ping Li, Li Xu, Yue Zhou, Ze'e Chen, Edward J. Kennelly, Chunlin Long
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
