期刊
FOOD CHEMISTRY
卷 141, 期 2, 页码 889-895出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2013.03.025
关键词
Costa Rican guava; Psidium friedrichsthalianum; Antioxidants; Interleukin-8 (IL-8); Matrix metalloproteinase-1 (MMP-1); Chronic obstructive pulmonary disease (COPD)
资金
- NIH-NHLBI [5SC1HL096016]
- NIH-NCCAM [F31AT00801]
- Spanish Ministry of Science and Innovation
The potential therapeutic effects of Costa Rican guava (Psidium friedrichsthalianum) extracts for chronic obstructive pulmonary disease were examined. The ethyl acetate fraction displayed the highest antioxidant activity, as compared to the hexane, chloroform, and n-butanol fractions, as well as the crude extract. This fraction was evaluated for its anti-inflammatory activity response relationship against interleukin-8 (IL-8) and inhibition of matrix metalloproteinase-1 (MMP-1) expression before and after treatment with cigarette smoke. The ethyl acetate fraction exhibited inhibitory activity against IL-8 production and MMP-1 expression, showing the most potent inhibitory activities in both assays at 100 mu g/mL, and nine compounds (1-9) were found. Phenolic compounds 1-O-trans-cinnamoyl-beta-D-glucopyranose (2), ellagic acid (3), myricetin (4), quercitrin (7), and quercetin (9) were identified using standard compounds or literature reports from related species. Compounds 1, 5, 6, and 8 were tentatively identified as 1,5-dimethyl citrate (1), sinapic aldehyde 4-O-beta-D-glucopyranose (5), 3,3',4-tri-O-methylellagic acid-4'-O-D-glucopyranoside (6), and 1,3-O-diferuloylglycerol (8), All nine compounds are reported for the first time in Costa Rican guava. (C) 2013 Elsevier Ltd. All rights reserved.
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