Article
Chemistry, Organic
Zhe Zhou, Zachary S. Sales, Daniel J. Pippel, Michael Qian, Connor L. Martin
Summary: We present a photocatalyst-free, diastereoselective decarboxylative alkylation method for (hetero)aryl sulfinimines using redox-active esters under blue light. This mild and efficient protocol demonstrates its utility as a versatile synthetic tool, especially for medicinal chemists.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Syed Anees Ali Jafri, Zafar Mehmood Khalid, Mohammad Rizwan Khan, Sadia Ashraf, Naushad Ahmad, Abdulnasser Mahmoud Karami, Ejaz Rafique, Mohamed Ouladsmane, Nouf Mohammad Saad Al Suliman, Summan Aslam
Summary: This study evaluated the antioxidant activities of extracts from different parts of traditionally used medicinal plants. The results showed that Euphrasiae stricta and Euphorbia platyphyllos L. had high levels of phenolic and flavonoid compounds and strong free radical scavenging activity. The highest antioxidant activity was observed in Euphrasiae stricta. These findings suggest that these medicinal plants can be used as important antioxidants for treating and inhibiting degenerative diseases caused by oxidative stress.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Chemistry, Organic
Aiswarya Purushothaman, Puthiyottil Jishnu Gopal, Deepa Janardanan
Summary: This study investigated the hydroperoxyl radical scavenging activity of oat avenanthramides using density functional theory. Three probable mechanisms were considered, and it was found that hydrogen atom transfer and sequential proton loss electron transfer were the most likely mechanisms. The results showed that sequential proton loss electron transfer was the preferred pathway in polar media, and avenanthramide C, characterized by an ortho-dihydroxy functionality, was the most potent radical scavenger.
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
(2022)
Article
Engineering, Environmental
Yajing Liu, Xinao Li, Qikun Pu, Rui Fu, Zhonghe Wang, Yu Li, Xixi Li
Summary: This study developed a systematic molecular design, screening, and performance evaluation method to design functionally improved, environmentally friendly, and synthesizable aromatic amine alternatives for the first time. The environmental fate and bladder carcinogenicity impacts of the designed alternatives were evaluated, and a high-performing candidate with low environmental impacts and carcinogenicity was identified.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Hyun Kim, Patrick J. Rogler, Savita K. Sharma, Andrew W. Schaefer, Edward I. Solomon, Kenneth D. Karlin
Summary: A new end-on low-spin ferric heme peroxide and subsequent hydroperoxide species were generated using iron-porphyrinate P-Im with its tethered imidazolyl group, with the OO-H bond-dissociation free energy of the hydroperoxide determined through thermodynamic parameters. The results were validated by observing the oxidizing ability of the superoxide complexes via hydrogen-atom transfer compared to a control group without the internally appended axial base imidazolyl.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Ioan Baldea
Summary: This article highlights the serious flaws in the recent reports on the antioxidant properties of atorvastatin in methanol, including incorrect data and inadequate estimation methods.
COMPUTATIONAL AND THEORETICAL CHEMISTRY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Ioan Baldea
Summary: This article presents two theorems that should be followed in studies on antioxidant activity and warns against assigning free radical scavenging pathways solely based on thermochemical descriptors.
Article
Materials Science, Multidisciplinary
Citlali Alejandra Marin-Flores, Odin Rodriguez-Nava, Margarita Garcia-Hernandez, Rosario Ruiz-Guerrero, Fernando Juarez-Lopez, Angel de Jesus Morales-Ramirez
Summary: ZnO particles were synthesized and their free radical scavenging activity properties were evaluated in this study. The results showed that the scavenging activity increased with smaller particle size and lower ZnO dosage. A pseudo-first-order kinetics model may be present in the reaction.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Chemistry, Analytical
Kimberly Fabijanczuk, Zaikuan Josh Yu, Rose M. Bakestani, Rayan Murtada, Nicholas Denton, Kaylee Gaspar, Tara Otegui, Jose Acosta, Hilkka I. Kenttamaa, Henk Eshuis, Gao Jinshan
Summary: Inspired by the electron-activated dissociation technique, this study investigates the mechanisms of free radical-induced glycan dissociation using isotope labeling. Various fragment ions generated by one-step collisional activation, including cross-ring, glycosidic bond, and combinational cleavages, are accurately assigned and confirmed by mass difference of isotope labeling. The findings provide fundamental knowledge for interpreting complex free radical-induced glycan spectra and differentiating stereoisomers.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Gyeong Min Lee, Se-jeong Kim, Eun Mi Kim, Eunhyung Kim, Sangmin Lee, Eunjin Lee, Hee Ho Park, Heungsoo Shin
Summary: A composite hydrogel incorporating epigallocatechin-gallate (EGCG)-coated nanofiber particles (EF) was developed. Compared to traditional GelMA hydrogel, this composite hydrogel showed significant improvements in cell viability, intracellular oxidative stress, and cell spreading and migration ability.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Ceramics
Zhaojun Qi, Sen Wang, Yan Li, Lifeng Wang, Lin Zhao, Qiang Ge, Jin Zhong Zhang
Summary: The novel free radical scavenger ML-Ti3C2Tx MXene exhibits high scavenging efficiency due to its intrinsic reducing property, rather than hydrogen donation ability from surface functional groups. The observed scavenging activity is attributed to the reducing property of ML-Ti3C2Tx, as compared to other materials.
CERAMICS INTERNATIONAL
(2021)
Article
Nanoscience & Nanotechnology
Daehong Ha, Joo Hyung Lee, Hyeri Jeon, Yoo Jin Kang, Junmo Jeon, Tae Hoon Lee, Seungwoo Hong, Young-Kwan Kim, Kyungtae Kang
Summary: The study demonstrated the importance of functional amyloid fibers in melanogenesis and their relationship with the intrinsic spin characters of melanin. It showed that adding an amyloid scaffold greatly increased the spin density in synthetic melanin and resulted in various alterations in its properties. This work provides insights into the role of functional amyloid in melanogenesis and the superiority of natural melanin over synthetic variants in terms of spin-related properties.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Chao Liu, Wen-Zhu Wang, Meng-Ting Song, Yao Lu, Ling-Ling Qian, Rui-Min Han, Leif H. Skibsted, Jian-Ping Zhang
Summary: The presence of Ca(II) affects the radical scavenging efficiency of structurally related flavonoids differently, with flavonoids containing 3', 4'-catechol and 3-hydroxyl, 4-carbonyl groups showing significant enhancement. The coordination of Ca(II) to kaempferol at the 3,4 site results in the most significant enhancement in radical scavenging efficiency compared to other investigated flavonoids. Genistein, despite its similar structure to apigenin, does not show an effect on radical scavenging rate when Ca(II) is added.
Article
Materials Science, Multidisciplinary
Haitao Yuan, Fujing Wang, Zhen Wang, Di Gu, Wei Huang, Chunjin Fu, Xiaoxian Wang, Jingbo Ma, Zhijie Li, Lingyun Dai, Xinzhou Zhang, Wei Xiao, Jigang Wang
Summary: In this study, a metal-phenolic nanozyme named RosA-Mn NPs was designed with broad spectrum antioxidant functionalities. The nanozyme promotes the recovery of mitochondrial function, reduces endoplasmic reticulum stress and secondary inflammation, and mitigates kidney damage through renal tubular targeting. In addition, RosA-Mn NPs also protect the kidney from oxidation and inflammation in an animal model.
ACS MATERIALS LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Madhu Sudan Dutta, Prithwish Mahapatra, Ashutosh Ghosh, Soumalee Basu
Summary: This study investigated the reducing power and electrochemical behavior of various classes of plant flavonoids, highlighting flavonols as having higher reducing power that decreases with methylation. Gossypetin was identified as the most effective flavonol, with compounds containing two hydroxyl groups in consecutive positions showing major activity as potential antioxidants.
MOLECULAR DIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Marko R. Antonijevic, Edina H. Avdovic, Dusica M. Simijonovic, Ziko B. Milanovic, Ana D. Amic, Zoran S. Markovic
Summary: This paper investigated the antioxidative properties and radical scavenging abilities of five different coumarin derivatives. The results showed that these compounds have good antioxidative potential and radical scavenging abilities, and they meet the criteria of drug-likeness tests. In addition, three additional mechanisms of radical scavenging activity were discovered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dusan S. Dimic, Goran N. Kaluderovic, Edina H. Avdovic, Dejan A. Milenkovic, Marko N. Zivanovic, Ivan Potocnak, Erika Samolova, Milena S. Dimitrijevic, Luciano Saso, Zoran S. Markovic, Jasmina M. Dimitric Markovic
Summary: In this study, four new compounds synthesized from 4-hydroxycoumarin and tyramine/octopamine/norepinephrine/3-methoxytyramine were characterized and analyzed spectroscopically, chromatographically, and structurally. The stability, antitumor activity, and ecotoxicology of these compounds were investigated using experimental and computational methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Koraljka Gall Troselj, Marko Tomljanovic, Morana Jaganjac, Tanja Matijevic Glavan, Ana Cipak Gasparovic, Lidija Milkovic, Suzana Borovic Sunjic, Brigitta Buttari, Elisabetta Profumo, Sarmistha Saha, Luciano Saso, Neven Zarkovic
Summary: This review explores the complex events involving oxidative stress and its end-products, such as 4-HNE, as well as NRF2, in the initiation, progression, and response to therapy in cancer. These events occur through interactions between cancer and stromal cells and rely on cell-type specific features.
Article
Plant Sciences
Tijana Micovic, Jelena S. Katanic Stankovic, Rudolf Bauer, Xuehong Nost, Zoran Markovic, Dejan Milenkovic, Vladimir Jakovljevic, Marina Tomovic, Jovana Bradic, Danijela Stesevic, Danilo Stojanovic, Zoran Maksimovic
Summary: The study found that hyssop herb has anti-inflammatory properties, making it a potential treatment option for inflammatory diseases. The extracts from hyssop herb showed significant inhibition of COX-2 enzyme in in vitro testing and demonstrated anti-inflammatory effects in in vivo testing. Preliminary in silico testing also showed that the organic acids in hyssop herb had better inhibitory activity against COX-1 and COX-2 enzymes compared to common non-steroidal anti-inflammatory drugs.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Oncology
Ivana Samarzija, Marko Tomljanovic, Renata Novak Kujundzic, Koraljka Gall Troselj
Summary: Cisplatin is a widely used chemotherapy drug for treating various types of cancer, but it has high toxicity and often leads to drug resistance. Combination therapies including cisplatin have been explored to address these issues. EZH2, an epigenetic regulator that is upregulated in many cancers, has been studied as a target for anticancer therapy. This review discusses the combined action of EZH2 inhibitors and cisplatin in different tumor types. The evidence suggests that this combination therapy could be beneficial for lung, ovarian, and breast cancers, but not recommended for testicular germ cell tumors due to the associated cisplatin resistance.
Editorial Material
Biochemistry & Molecular Biology
Visnja Stepanic, Marta Kucerova-Chlupacova
Article
Biochemistry & Molecular Biology
Jelena Katanic S. Stankovic, Jelena Dorovic Jovanovic, Danijela Misic, Uros Gasic, Stefanie Nikles, Zoran Markovic, Rudolf Bauer
Summary: R. holostea is a medicinal plant with antioxidant, antimicrobial, and anti-inflammatory properties. It contains phenolic acids, flavonoids, and flavonoid glucosides as its main constituents. It is widely distributed in Europe, Western Asia, and North Africa, and was previously used in salads or for the treatment of inflammatory disorders.
Review
Biochemistry & Molecular Biology
Visnja Stepanic, Marta Kucerova-Chlupacova
Summary: Ferroptosis is a cell death pathway that can be targeted in cancer and neurodegenerative diseases. This review focuses on polyphenolic modulators, particularly phenylpropanoids, which can act as antioxidants or inducers of ferroptosis. These molecules have dual modes of action depending on the cell type and environment. Some of them have been successfully used in nanoparticles designed to selectively target cancer cells through ferroptosis induction.
Article
Oncology
Ivana Samarzija, Koraljka Gall Troselj, Pasko Konjevoda
Summary: Prostate cancer is a highly heterogenous disease with respect to molecular, morphological and clinical features, and defining risk subgroups is crucial for treatment approach. Amino acid metabolism-related genes show highly aberrant expression in prostate cancer, which can be used for disease progression parameters and therapeutic targets. Gleason score is a strong prognostic factor for progression-free survival, and the expression of SERINC3 and CSAD genes can refine prognosis for high and low Gleason scores, respectively, suggesting potential biomarkers for prostate cancer.
Review
Pharmacology & Pharmacy
Daniel L. Pouliquen, Koraljka Gall Troselj, Ruby John Anto
Summary: The number of published studies on curcuminoids in cancer research, including its lead molecule curcumin and synthetic analogs, has been increasing substantially during the past two decades. Insights on the diversity of inhibitory effects they have produced on a multitude of pathways involved in carcinogenesis and tumor progression have been provided. This review will also cover the use of curcuminoids as chemosensitizing molecules that can be combined with several anticancer drugs to reverse the phenomenon of multidrug resistance.
Article
Biochemistry & Molecular Biology
Ema Vrbanovic, Marko Zlendic, Koraljka Gall Troselj, Marko Tomljanovic, Kristina Vukovic Derfi, Iva Z. Alajbeg
Summary: This study compared the frequency of selected polymorphisms in genes related to antioxidative properties between patients with pain-related temporomandibula disorder and control subjects. It also investigated the association between these gene polymorphisms and participants' psychological and psychosomatic characteristics. However, the gene polymorphisms were not found to be significant risk factors for either TMDp or sleep-related oral behaviours.
Review
Biochemistry & Molecular Biology
Drago Beslo, Natasa Golubic, Vesna Rastija, Dejan Agic, Maja Karnas, Domagoj Subaric, Bono Lucic
Summary: As the world's population grows, there is an increasing need for more animal feed. In 2006, the EU banned the use of antibiotics and other chemicals to reduce chemical residues in human food. Plant polyphenols are gaining attention as a supplement to animal feed, leading to healthier animal products with higher polyunsaturated fatty acids. Adding polyphenols to animal nutrition can improve animal welfare, reduce stress, and enhance the quality of food of animal origin.
Article
Biochemistry & Molecular Biology
Vesna Pehar, Dora Kolic, Antonio Zandona, Goran Sinko, Maja Katalinic, Visnja Stepanic, Zrinka Kovarik
Summary: This study compared 346 herbicides currently in use and 163 no longer in use with cholinesterase inhibitors and drugs in terms of their physicochemical profile and estimated toxic effects on human health. The results showed potential adverse consequences for each herbicide class, with the classes K1, K3/N, F1, and E having the most toxic warnings. In vitro tests revealed that the organophosphate anilofos and oxyacetanilide flufenacet were the most potent inhibitors of acetylcholinesterase and butyrylcholinesterase, respectively. Some herbicides also exhibited cytotoxicity towards hepatocytes and neuroblastoma cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Chemistry, Organic
Irena Dokli, Zlatko Brkljaca, Petra Svaco, Lixia Tang, Visnja Stepanic, Maja Majeric Elenkov
Summary: This study tested ten different fluorinated aromatic epoxides as potential substrates for halohydrin dehalogenase, showing the synthesis of enantioenriched fluorinated organic compounds in azidolysis reactions. By introducing mutations, the enantioselectivity of the enzyme towards substrates was successfully altered, expanding its application possibilities.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jelena Dorovic Jovanovic, Marko Antonijevic, Radisa Vojinovic, Nenad D. Filipovic, Zoran Markovic
Summary: Heart failure is a life-threatening condition that commonly affects elderly individuals, especially those with obesity, diabetes, or other chronic conditions. Entresto, a relatively new medication, has shown promising results in its treatment. This study utilized molecular docking and molecular dynamics simulations to investigate the inhibitory capacity of Entresto. The simulations revealed that Entresto interacts with targeted proteins and inhibits their physiological function. Sacubitril (SAC) produced structural alterations in neprilysin, reducing its activity, while valsartan (VAL) caused deviations in the structure of angiotensin receptors. Overall, the results indicate that both SAC and VAL have inhibitory potential towards neprilysin and angiotensin receptors, respectively.
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
