Article
Chemistry, Physical
Tatiane Roquete Amparo, Anne Cherem Peixoto da Silva, Janaina Brandao Seibert, Debora dos Santos da Silva, Viviane Martins Rebello dos Santos, Paula Melo de Abreu Vieira, Geraldo Celio Brandao, Gustavo Henrique Bianco de Souza, Bianca Aloise Maneira Correa Santos
Summary: This study investigated the photoprotective potential of Protium spruceanum leaves and its main flavonoids. It found that the extract protected cells against oxidative stress-induced cell death and showed excellent free radical scavenging and UV absorption properties.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Applied
Nuan Han, Xiaoqi Chen, Hong Wang, Nana Wang, Miaoxiang Nian, Dongmei Wang
Summary: In this study, a novel and efficient continuous process was developed for the extraction and separation of hyperoside and quercitrin from Zanthoxylum bungeanum leaves. The process involved the use of aqueous two-phase system, back-extraction with dichloromethane-water system, and S-8 macroporous resin for salt removal. The method achieved high recoveries and purity, and showed potential for industrial production.
NATURAL PRODUCT RESEARCH
(2023)
Article
Multidisciplinary Sciences
Maddumage Dona Ginushika Priyadarshani Premarathne, Nami Fukutome, Kazuaki Yamasaki, Fumiyo Hayakawa, Atsushi J. Nagano, Hisataka Mizuno, Nobuo Ibaragi, Yukio Nagano
Summary: Japanese pepper has four main lineages, and analysis reveals different stages of domestication, with spineless plants being polyphyletic.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Seung-Won Yun, Young-Jin Seo, Jeong Eun Kwon, Dae Won Park, Yeong-Geun Lee, Tae Hwan Choe, Seul-Ki Kim, Hak Sung Lee, Hyunggun Kim, Se Chan Kang
Summary: Zanthoxylum piperitum extract (ZPE-LR) has been found to significantly alleviate pain and inflammation in collagen-induced arthritic (CIA) mice, prevent joint damage and phalangeal injury. Its anti-inflammatory and analgesic effects are attributed to the reduction of inflammatory mediators and the modulation of phosphor-ERK and BDNF levels.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Applied
Mirko Umberto Granata, Francesco Bracco, Rosangela Catoni, Valeria Cavalloro, Emanuela Martino
Summary: The study analyzed the production of leaf secondary metabolites and physiological traits in hazelnut, revealing higher concentrations of flavonoids in the wild type than in the cultivar. This difference may be attributed to the ecological role of flavonoids and the genetic background of the cultivar, which requires less production of these compounds due to controlled environmental conditions.
NATURAL PRODUCT RESEARCH
(2021)
Article
Environmental Sciences
Saulo Duarte Ozelin, Juliana Marques Senedese, Jacqueline Morais Alves, Carla Carolina Munari, Juliana De Carvalho Da Costa, Flavia Aparecida Resende, Debora Leite Campos, Ildercilio Mota De Souza Lima, Augusto Faria Andrade, Eliana Aparecida Varanda, Jairo Kenupp Bastos, Denise Crispim Tavares
Summary: The study found that the aerial parts extract of Copaifera langsdorffii has antioxidant activity and can exhibit antigenotoxic effects against certain mutagenic substances.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2021)
Article
Biochemistry & Molecular Biology
Tatsunosuke Tomita, Yasuhiro Kawano, Masahiro Kassai, Hiroyuki Onda, Yoshihiro Nakajima, Koyomi Miyazaki
Summary: We demonstrated that hydroxy-beta-sanshool, a secondary metabolite in Zanthoxylum piperitum, can shorten the circadian rhythm at the cellular level. It also upregulates the expression of clock genes and clock-controlled oxidative stress responsive genes.
Review
Biochemistry & Molecular Biology
Eungyeong Jang
Summary: Hyperoside, a flavonol glycoside abundant in various fruits, vegetables, and medicinal plants, has been suggested to exhibit cardiovascular, renal, neuroprotective, antifungal, antifibrotic, and anticancer effects. This review summarizes preclinical data on the beneficial effects of Hyperoside in improving liver pathophysiology and focuses on its hepatic antioxidant defense signaling in liver diseases.
Article
Biochemistry & Molecular Biology
Xinyu Zhang, Jianqing Su, Xiaoya Wang, Xueyan Wang, Ruixue Liu, Xiang Fu, Ying Li, Jiaojiao Xue, Xiaoli Li, Rui Zhang, Xiuling Chu
Summary: This study prepared inclusion complexes of Hyperoside (Hyp) with different cyclodextrins (CD) using the ultrasonic method and characterized them. The results showed that the inclusion complexes significantly improved the solubility and antioxidant activity of Hyp. This research provides useful information for the potential clinical application of complexation with Hyp.
Article
Plant Sciences
Mi Hye Kim, Haesu Lee, In Jin Ha, Woong Mo Yang
Summary: ZP administration in osteoporotic mice resulted in increased bone mineral density, restoration of serum bone biomarker levels, decreased osteoclast counts, and inhibition of osteoclast formation. These findings suggest that ZP may be a potential therapeutic agent for osteoporosis.
Article
Immunology
Yongqing Cai, Bin Li, Dan Peng, Xianfeng Wang, Pan Li, Mingchun Huang, Haiyan Xing, Jianhong Chen
Summary: This study revealed that Hyp can protect the liver from oxidative damage by promoting Bach1 nuclear export and enhancing Nrf2 binding to ARE. Furthermore, this protective effect is achieved by enhancing Crm1 expression and ERK1/2 activity.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biology
Kikwang Oh, Md Adnan, Dongha Cho
Summary: This study aimed to investigate the bioactives of Zanthoxylum piperitum fruits on rheumatoid arthritis using network pharmacology. The results suggest that Zanthoxylum piperitum fruits may alleviate inflammatory symptoms of rheumatoid arthritis, making it a promising herbal treatment option.
Review
Chemistry, Medicinal
Junren Chen, Gangmin Li, Chen Sun, Fu Peng, Lei Yu, Yan Chen, Yuzhu Tan, Xiaoyu Cao, Yunli Tang, Xiaofang Xie, Cheng Peng
Summary: This paper systematically reviews the natural sources, pharmacological activities, and roles of quercitrin in various diseases, as well as its pharmacokinetics, structure-activity relationship, and toxicity. The underlying molecular mechanisms of quercitrin in treating related diseases and the dose-effect relationships are discussed, along with the need for further high-quality studies to establish its clinical efficacy.
PHYTOTHERAPY RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Ye Seul Park, Gun He Nam, Kyung Jo Jo, Hye Won Kawk, Sang Yung Kim, Young Min Kim
Summary: The study demonstrated that Zanthoxylum piperitum extract (ZPE) inhibits the proliferation of AGS gastric cancer cells and induces apoptosis by suppressing Akt and MDM2 expression.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Ye Seul Park, Gun He Nam, Kyung Jo Jo, Hye Won Kawk, Sang Yung Kim, Young Min Kim
Summary: The study demonstrated that Zanthoxylum piperitum extract (ZPE) inhibits the growth of gastric cancer cells and induces apoptosis. ZPE modulates the expression of apoptosis-related proteins to impact cell apoptosis, providing a new direction and strategy for gastric cancer treatment.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Food Science & Technology
Seul Ki Yoo, Jin Yong Kang, Uk Lee, Seon Kyeong Park, Jong Min Kim, Hye Ju Han, Dae Ok Kim, Ho Jin Heo
Summary: The study found that EFAL can improve cognitive decline caused by hyperglycemia by reducing oxidative stress and suppressing the decrease of neurotransmitters.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Chemistry, Medicinal
Hye Ju Han, Seon Kyeong Park, Jin Yong Kang, Jong Min Kim, Seul Ki Yoo, Dae-Ok Kim, Gun-Hee Kim, Ho Jin Heo
Summary: The mixture P4F6 showed a potential anti-amnesic effect on A beta-induced cognitive deficit mice by reducing oxidative stress, enhancing mitochondrial function, regulating tau hyperphosphorylation, promoting BDNF expression, and improving cholinergic system function.
Article
Biochemistry & Molecular Biology
Hyoung-Geun Kim, Youn Hee Nam, Young Sung Jung, Seon Min Oh, Trong Nguyen Nguyen, Min-Ho Lee, Dae-Ok Kim, Tong Ho Kang, Dae Young Lee, Nam-In Baek
Summary: The study identified high flavonoid content in Coreopsis lanceolata flowers (CLFs) and isolated four flavonoids with antioxidative and anti-inflammatory activities, potentially serving as anti-diabetic agents.
Article
Biochemistry & Molecular Biology
Min-Jeong Kim, Eun-Sang Hwang, Kwan Joong Kim, Sungho Maeng, Ho Jin Heo, Ji-Ho Park, Dae-Ok Kim
Summary: This study found that EGCG can alleviate scopolamine-induced learning and memory impairments and improve brain function. This may be achieved through mechanisms such as improving cholinergic function and reducing oxidative stress.
Article
Chemistry, Applied
Mi-Seon Kim, Young Sung Jung, Davin Jang, Chi Heung Cho, Sang-Hoon Lee, Nam Soo Han, Dae-Ok Kim
Summary: This study evaluated the antioxidant capacity, bioaccessibility, and bioavailability of 12 soy isoflavones (SIs). The results showed that SIs were stable under gastric digestion conditions but unstable under small intestinal digestion conditions for acetyl and malonyl conjugates. SI aglycones had higher permeability and cellular accumulation than their glucosides. A small amount of intact SI conjugates were found in the cell and in the basolateral side of each Transwell.
Article
Food Science & Technology
Briana M. Nosal, Junichi R. Sakaki, Dae-Ok Kim, Ock K. Chun
Summary: The brewing methods and types of coffee can affect the antioxidant capacity of coffee consumers, with capsule coffee showing higher total phenolic content and antioxidant capacity.
FOOD SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Eun-Sang Hwang, Ga-Young Choi, Kwan Joong Kim, Min-Jeong Kim, Seok Lee, Jin-Won Lee, Dae-Ok Kim, Ji-Ho Park
Summary: Vitamin C (VC) can lower blood pressure in spontaneously hypertensive rats (SHRs) by directly targeting ACE I production and may improve endothelial function, with the frequency of administration affecting its effectiveness.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Agriculture, Multidisciplinary
Young Sung Jung, Hyoung-Geun Kim, Seon Min Oh, Dae Young Lee, Cheon-Seok Park, Dae-Ok Kim, Nam-In Baek
Summary: Using amylosucrase from Deinococcus geothermalis, alpha-linked glucosylation of Soybean isoflavone aglycones (SIAs) was achieved, resulting in 13 alpha-linked glucosyl SIAs with confirmed colors in solution. The structures of the compounds were identified using mass spectrometry and multidimensional nuclear magnetic resonance spectroscopy. The study suggests a strategy for the synthesis of bioactive compounds with enhanced water solubility through alpha-linked glucosylation, with the products attached to the C-4 ' of SIAs found to be more water-soluble than those attached to the C-7 and/or beta-linkages.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kwan Joong Kim, Eun-Sang Hwang, Min-Jeong Kim, Chan-Su Rha, Myoung Chong Song, Sungho Maeng, Ji-Ho Park, Dae-Ok Kim
Summary: The study demonstrated the cognitive-enhancing effect of Pinus densiflora Sieb. et Zucc. bark extract (PBE). PBE improved cognitive impairment in rats through its antioxidant properties and enhancement of long-term potentiation (LTP) induction in organotypic hippocampal slices.
Article
Chemistry, Applied
Chan-Su Rha, Eun Kyu Jang, Jong Suk Lee, Ji-Sung Kim, Min-Ji Ko, Sol Lim, Gun Hwan Park, Dae-Ok Kim
Summary: A study was conducted on the chemical constituents of soybean leaves and their correlations across phenotypes, growing periods, and cultivation areas using targeted metabolomics and machine learning models. The distribution of isoflavones and flavonols was found to be influenced by the growing period and cultivation area, and the neural network model showed the best predictive capacity for the differences in soybean leaves.
Article
Food Science & Technology
Ga-Young Choi, Kwan Joong Kim, Ho-Sub Park, Eun-Sang Hwang, Jae-Min Cho, Hyun-Bum Kim, Dae-Ok Kim, Ji-Ho Park
Summary: The study investigated the potential anti-atopic dermatitis (AD) effects of a herbal combination of Lithospermum erythrorhizon (LE), Houttuynia cordata (HC), and Spirodela polyrhiza (SP). Through ultra-high-pressure liquid chromatography (UHPLC)-Orbitrap mass spectrometer (MS), a total of 42 compounds were identified in LE, HC, SP, and the combined herb extract of LE, HC, and SP (LHS). The LHS showed increased concentration of flavonoid glycosides compared to individual extracts, and effectively inhibited the key characteristics of AD such as epidermal thickness increase, mast cell proliferation, and immunoglobulin E release.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Review
Food Science & Technology
Young Sung Jung, Hyunbin Seong, Nam Soo Han, Dae-Ok Kim
Summary: Soybean is an important crop and a significant dietary source of isoflavones. Understanding the bioaccessibility and bioavailability of soy isoflavones is crucial for comprehending their bioactivities. This review evaluates reports using in vitro methods to study the bioavailability of soy isoflavones and discusses how their molecular structures influence their bioactivities.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Food Science & Technology
Eun-Ha Park, Inil Lee, Gi-Cheol Park, Seung-Ju Lee, Kwan Joong Kim, Jisuk Yun, Dae-Ok Kim
Summary: Canola meal, a by-product of canola oil processing, has antioxidant and skin anti-aging effects. This is due to the bioactive compounds found in canola meal, particularly the antioxidative phenolics present in canola meal extract (CME).
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Young Sung Jung, Hyoung-Geun Kim, Seon Min Oh, Dae Young Lee, Cheon-Seok Park, Dae-Ok Kim, Nam-In Baek
Summary: Soybean isoflavone aglycones (SIAs) have low water solubility in the human body. By glycosylation, SIAs can obtain structural diversity and change their physicochemical properties, including water solubility. The alpha-linked glucosylation of SIAs was achieved using amylosucrase from Deinococcus geothermalis. 13 alpha-linked glucosyl SIAs were obtained and their structures were identified by mass spectrometry and multidimensional nuclear magnetic resonance spectroscopy. The glucosylated SIAs attached to C-4' were found to be more water-soluble than those attached to C-7 and/or beta-linkages.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Min Young Um, Minseok Yoon, Minji Kim, Jonghoon Jung, Seonghui Kim, Dae-Ok Kim, Suengmok Cho
Summary: This study aimed to investigate the effects and underlying mechanisms of curcuminoids and their constituents on the sleep-wake cycle of mice. The results showed that curcuminoids reduced sleep latency and increased sleep duration by interacting with H1R. These findings suggest the potential importance of curcuminoids in treating insomnia.
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
