Article
Biochemistry & Molecular Biology
Sara Pagnotta, Antonella Tramutola, Eugenio Barone, Fabio Di Domenico, Valeria Pittala, Loredana Salerno, Valentina Folgiero, Matteo Caforio, Franco Locatelli, Stefania Petrini, D. Allan Butterfield, Marzia Perluigi
Summary: This study focuses on the role of BACH1/NRF2 ratio in the regulation of antioxidant response and its impact on patients with Down syndrome. The results show that overexpression of BACH1 disrupts the induction of antioxidant response genes, leading to oxidative damage accumulation. Additionally, administration of CAPE and VP961 promotes NRF2 nuclear translocation in cells from Down syndrome patients, improving antioxidant response.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jun Lu, Yi Zhang, Huiyue Dong, Jingjing Sun, Ling Zhu, Pengyang Liu, Fuli Wen, Rong Lin
Summary: Triptolide activates the cGAS-STING signaling pathway in kidney tubular cells, leading to renal injury. Inhibiting over-activation of the cGAS-STING pathway may be a new strategy to alleviate triptolide-induced nephrotoxicity.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Manuj Ahuja, Navneet Ammal Kaidery, Debashis Dutta, Otis C. Attucks, Eliot H. Kazakov, Irina Gazaryan, Mitsuyo Matsumoto, Kazuhiko Igarashi, Sudarshana M. Sharma, Bobby Thomas
Summary: Parkinson's disease is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons. Although the exact cause is unclear, oxidative stress, mitochondrial dysfunction, neuroinflammation, and disruption of calcium homeostasis have been proposed as contributing factors. While drugs targeting these pathways have shown promise in preclinical models, a more effective therapeutic approach involving the activation of the Nrf2/Bach1 signaling pathway is being explored. This review discusses the potential benefits of simultaneously inhibiting Bach1 and stabilizing Nrf2 for the treatment of Parkinson's disease.
Article
Medicine, Research & Experimental
Daijin Li, Jing Xu, Jie Chang, Yujue Wang, Xiaoye Du, Hanhan Wu, Jingang Cui, Peiwei Wang, Teng Zhang, Yu Chen
Summary: Through in vitro and in vivo experiments, this study demonstrates for the first time that hyperoside can protect photoreceptors from oxidative stress-induced mitochondrial dysfunction and cell death, thereby reducing the degeneration of retinal projection cells and maintaining retinal homeostasis. These findings suggest that hyperoside has the potential to be a protective agent for the treatment of related photoreceptor degenerative diseases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Weifeng Zhu, Ming Ge, Xiuyu Li, Jiangfeng Wang, PanPan Wang, Tiange Tai, Yuxi Wang, Jianxu Sun, Guangliang Shi
Summary: The study found that hyperoside inhibited spleen injury caused by zearalenone through its antioxidant and anti-apoptotic effects. This provides a new treatment option for immune system diseases caused by zearalenone.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Neurosciences
Kexin Wang, Xinyue Zhang, Miaosi Zhang, Xin Li, Jiao Xie, Suwen Liu, Qun Huang, Jilite Wang, Qingbin Guo, Hao Wang
Summary: Traditional Chinese medicines with hyperoside such as Acanthopanax senticosus and Crataegus pinnatifida have demonstrated anti-oxidative stress properties. Hyperoside, the main component of antioxidant herbs, may delay the onset of neurodegenerative diseases. This study investigated the therapeutic mechanism of hyperoside as a natural antioxidant against Alzheimer's disease in Caenorhabditis elegans and PC12 cells, showing its ability to reduce reactive oxygen species levels and neurotoxicity induced by A beta 42.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lun Cai, Ali S. Arbab, Tae Jin Lee, Ashok Sharma, Bobby Thomas, Kazuhiko Igarashi, Raghavan Pillai Raju
Summary: The deletion of Bach1 gene improves organ function and survival in sepsis. It enhances antioxidant response, reduces oxidative stress and inflammation, preserves mitochondrial function, and regulates gene expression related to lipid metabolism. Bach1 deficiency also improves liver and lung blood flow in septic mice.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Medicinal
Shanshan Wei, Wanjun Ma, Chuanhao Jiang, Jiaqin Liu, Jian Liu, Bikui Zhang, Wenqun Li
Summary: The present study aimed to demonstrate the effect and mechanism of hyperoside in Doxorubicin-induced cardiotoxicity. Hyperoside attenuated the cardiac dysfunction and cardiomyocyte apoptosis induced by Doxorubicin, mainly through inhibiting the NOXs/ROS/NLRP3 inflammasome signaling pathway, which is related to oxidative stress.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Kazi Nadim Hossain, Md. Shafiqul Islam, Sheikh Hasibur Rahman, Subroto Sarker, Milon Mondal, Mohammad Asikur Rahman, Sadeq K. Alhag, Laila A. Al-Shuraym, Othman A. Alghamdi, Muhammad Torequl Islam, Ammar AL-Farga, Mohamed El-Shazly, Md. Jahir Alam, Heba A. S. El-Nashar
Summary: This study investigated the antioxidant, anti-inflammatory, and hepatoprotective activities of Wissadula periplocifolia. The results showed that it has strong antioxidant, anti-inflammatory, and hepatoprotective effects.
Article
Biochemistry & Molecular Biology
Sasa Vukmirovic, Vladimirka Ilic, Vanja Tadic, Ivan Capo, Nebojsa Pavlovic, Ana Tomas, Milica Paut Kusturica, Natasa Tomic, Svetolik Maksimovic, Nebojsa Stilinovic
Summary: This study aimed to investigate the chemical composition and antioxidant/hepatoprotective activity of black mulberry extracts obtained from different parts of the plant. Various extraction methods were used to obtain the extracts, and spectrophotometric, HPLC, and GC methods were employed for chemical composition analysis. In vitro and in vivo assays were conducted to evaluate antioxidant activity. The results showed that black mulberry leaf and bark extracts, as well as seed oil, exhibited significant antioxidant activity and had beneficial effects on liver tissue integrity.
Article
Biochemistry & Molecular Biology
Linlin Qu, Rongzhan Fu, Xiaoxuan Ma, Daidi Fan
Summary: Ginsenoside Rk3 shows promising therapeutic potential in protecting against APAP-induced acute liver injury by reducing hepatotoxicity, inhibiting liver inflammation and oxidative stress, and promoting continuous activation of autophagy.
Article
Microbiology
Ji Yeon Lee, Hyemin Kim, Yulah Jeong, Chang-Ho Kang
Summary: This study evaluated the protective effects of different lactic acid bacteria strains in ethanol-induced liver cells, with nine strains increasing ALDH levels and reducing lipid peroxidation and liver transferase. Specifically, L. brevis MG5280 and MG5311, L. reuteri MG5458, and L. fermentum MG4237 and MG4294 protected cells by regulating various factors involved in alcohol-induced liver damage.
Article
Biochemistry & Molecular Biology
Ying Tong, Mei-Hui Zhou, Sheng-Peng Li, Hui-Min Zhao, Ya-Ru Zhang, Dan Chen, Ya-Xian Wu, Qing-Feng Pang
Summary: The malfunction of vascular smooth muscle cells (VSMCs) is an initiating factor in the pathogenesis of pathological vascular remodeling, including hypertension-related vascular lesions. MicroRNAs (miRNAs) have been implicated in the development of VSMC proliferation and migration in cardiovascular remodeling. This study reveals that miR-155-5p attenuates VSMC migration and ameliorates vascular remodeling in spontaneously hypertensive rats (SHRs) by suppressing BACH1 expression.
Article
Immunology
Samia Salem Sokar, Mahmoud Abdelrahman Alkabbani, El-Sayed Akool, Sally El- Sayed Abu-Risha
Summary: The study demonstrated that carvedilol, crocin, and their combination have significant protective effects against leflunomide-induced liver injury. The combination treatment was found to be more effective than either drug alone.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Suzy Salama, Chin Siang Kue, Haryanti Mohamad, Fatima Omer, Mohamed Yousif Ibrahim, Mahmood Abdulla, Hapipah Ali, Abdalbasit Mariod, Soher Nagi Jayash
Summary: This study evaluated the antioxidant capacity and hepatoprotective potential of the compound quinazoline Q-Br in rats with sub-chronic liver toxicity. The results showed that Q-Br had mild antioxidant capacity, improved liver status, and inhibited oxidative stress. There was also a reduction in the degree of fibrosis. These findings suggest that Q-Br has significant hepatoprotective potential.
FRONTIERS IN PHARMACOLOGY
(2022)