AROS has a context-dependent effect on SIRT1

Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol

(2013) Mahadevan Lakshminarasimhan et al.   BIOSCIENCE REPORTS

Active regulator of SIRT1 is required for ribosome biogenesis and function

(2013) John R. P. Knight et al.   NUCLEIC ACIDS RESEARCH

The SIRT1 Modulators AROS and DBC1 Regulate HSF1 Activity and the Heat Shock Response

(2013) Rachel Raynes et al.   PLoS One

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity

(2013) J. R. P. Knight et al.   Open Biology

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells—Implications for age-related macular degeneration (AMD)

(2012) Anu Kauppinen et al.   IMMUNOLOGY LETTERS

Sirtuin Catalysis and Regulation

(2012) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From Sirtuin Biology to Human Diseases: An Update

(2012) Carlos Sebastián et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Are sirtuins viable targets for improving healthspan and lifespan?

(2012) Joseph A. Baur et al.   NATURE REVIEWS DRUG DISCOVERY

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

(2012) Melanie Gertz et al.   PLoS One

Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase

(2011) Tarja Kokkola et al.   FEBS LETTERS

Structure-Based Design of Pseudopeptidic Inhibitors for SIRT1 and SIRT2

(2011) Tero Huhtiniemi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptide Switch Is Essential for Sirt1 Deacetylase Activity

(2011) Hyeog Kang et al.   MOLECULAR CELL

Sirtuins, Aging, and Medicine

(2011) Leonard Guarente   NEW ENGLAND JOURNAL OF MEDICINE

Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor α activity and co-activator synergy

(2011) Eun Ji Yu et al.   NUCLEIC ACIDS RESEARCH

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Nε-Modified lysine containing inhibitors for SIRT1 and SIRT2

(2010) Tero Huhtiniemi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Interactions between DBC1 and SIRT1 are deregulated in breast cancer cells

(2010) Ja-Eun Kim et al.   CELL CYCLE

Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice

(2010) Carlos Escande et al.   JOURNAL OF CLINICAL INVESTIGATION

SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence

(2010) Limin Han et al.   NUCLEIC ACIDS RESEARCH

Comparative deacetylase activity of wild type and mutants of SIRT1

(2009) Renu Malik et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nϵ-Thioacetyl-Lysine-Containing Tri-, Tetra-, and Pentapeptides as SIRT1 and SIRT2 Inhibitors

(2009) Päivi H. Kiviranta et al.   JOURNAL OF MEDICINAL CHEMISTRY

CK2 Is the Regulator of SIRT1 Substrate-Binding Affinity, Deacetylase Activity and Cellular Response to DNA-Damage

(2009) Hyeog Kang et al.   PLoS One

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Negative regulation of the deacetylase SIRT1 by DBC1

(2008) Wenhui Zhao et al.   NATURE

DBC1 is a negative regulator of SIRT1

(2008) Ja-Eun Kim et al.   NATURE

Phosphorylation Regulates SIRT1 Function

(2008) Tsutomu Sasaki et al.   PLoS One