Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity

Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer

(2013) E. Wauters et al.   CANCER RESEARCH

Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism

(2013) Basil P Hubbard et al.   CELL CYCLE

Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes

(2013) Anna Biason-Lauber et al.   Cell Metabolism

The Ribosome as a Hub for Protein Quality Control

(2013) Sebastian Pechmann et al.   MOLECULAR CELL

Active regulator of SIRT1 is required for ribosome biogenesis and function

(2013) John R. P. Knight et al.   NUCLEIC ACIDS RESEARCH

The SIRT1 Modulators AROS and DBC1 Regulate HSF1 Activity and the Heat Shock Response

(2013) Rachel Raynes et al.   PLoS One

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

Janus-faced role of SIRT1 in tumorigenesis

(2012) Na-Young Song et al.   Annals of the New York Academy of Sciences

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

Epigenetics, sirtuins and osteoarthritis

(2012) Odile Gabay et al.   JOINT BONE SPINE

Translation drives mRNA quality control

(2012) Christopher J Shoemaker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expression patterns and potential roles of SIRT1 in human medulloblastoma cellsin vivoandin vitro

(2012) Jing-Xin Ma et al.   NEUROPATHOLOGY

SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis

(2011) Hsieh-Cheng Chen et al.   ANNALS OF SURGICAL ONCOLOGY

Changes in ribosome biogenesis may induce cancer by down-regulating the cell tumor suppressor potential

(2011) Lorenzo Montanaro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

(2011) H. Yuan et al.   BLOOD

SIRT1 Is Essential for Oncogenic Signaling by Estrogen/Estrogen Receptor   in Breast Cancer

(2011) S. Elangovan et al.   CANCER RESEARCH

Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth

(2011) J. Chen et al.   CANCER RESEARCH

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

SIRT1, metabolism and cancer

(2011) John R.P. Knight et al.   CURRENT OPINION IN ONCOLOGY

SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells

(2011) G Zhao et al.   GENE THERAPY

Sirt1 deacetylates c-Myc and promotes c-Myc/Max association

(2011) Beibei Mao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis

(2011) D. U. Frank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability

(2011) Glenn M. Marshall et al.   PLoS Genetics

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma

(2010) Ho Lee et al.   HUMAN PATHOLOGY

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

(2010) B Wang et al.   ONCOGENE

Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway

(2010) C Deisenroth et al.   ONCOGENE

SIRT1 Undergoes Alternative Splicing in a Novel Auto-Regulatory Loop with p53

(2010) Cian J. Lynch et al.   PLoS One

Cellular Regulation of SIRT1

(2009) Jo Milner   CURRENT PHARMACEUTICAL DESIGN

p53 regulates LIF expression in human medulloblastoma cells

(2009) Euan W. Baxter et al.   JOURNAL OF NEURO-ONCOLOGY

Human Sirt-1: Molecular Modeling and Structure-Function Relationships of an Unordered Protein

(2009) Ida Autiero et al.   PLoS One

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

PTEN Acetylation Modulates Its Interaction with PDZ Domain

(2008) T. Ikenoue et al.   CANCER RESEARCH

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

(2008) Alexander S. Banks et al.   Cell Metabolism

Negative regulation of the deacetylase SIRT1 by DBC1

(2008) Wenhui Zhao et al.   NATURE

DBC1 is a negative regulator of SIRT1

(2008) Ja-Eun Kim et al.   NATURE

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

(2008) Ron Firestein et al.   PLoS One