Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10

Tetraspanins Regulate ADAM10-Mediated Cleavage of TNF-  and Epidermal Growth Factor

(2014) C. Arduise et al.   JOURNAL OF IMMUNOLOGY

Two dileucine motifs mediate late endosomal/lysosomal targeting of transmembrane protein 192 (TMEM192) and a C-terminal cysteine residue is responsible for disulfide bond formation in TMEM192 homodimers

(2011) Jörg Behnke et al.   BIOCHEMICAL JOURNAL

Constitutive activation of metalloproteinase ADAM10 in mantle cell lymphoma promotes cell growth and activates the TNF /NF B pathway

(2011) H. Armanious et al.   BLOOD

Functional interplay between tetraspanins and proteases

(2011) María Yáñez-Mó et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

(2011) S. Weber et al.   DEVELOPMENT

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

(2011) Hermann C Altmeppen et al.   Molecular Neurodegeneration

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Upregulation of the α-secretase ADAM10 - risk or reason for hope?

(2010) Kristina Endres et al.   FEBS Journal

An Arginine Stretch Limits ADAM10 Exit from the Endoplasmic Reticulum

(2010) Elena Marcello et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

(2010) E. Jorissen et al.   JOURNAL OF NEUROSCIENCE

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

The role of ADAMs in disease pathophysiology

(2009) Michael J. Duffy et al.   CLINICA CHIMICA ACTA

Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein

(2009) Daosong Xu et al.   FASEB JOURNAL

Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin

(2009) Frank Tippmann et al.   FASEB JOURNAL

Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand β-glucocerebrosidase

(2009) Judith Blanz et al.   HUMAN MOLECULAR GENETICS

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

(2009) Thomas Tousseyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains

(2009) Tomoko Wakabayashi et al.   NATURE CELL BIOLOGY

ADAM10 is essential for proteolytic activation of Notch during thymocyte development

(2008) L. Tian et al.   INTERNATIONAL IMMUNOLOGY

Differential expression of five members of the ADAM family in the developing chicken brain

(2008) J. Lin et al.   NEUROSCIENCE

The “A Disintegrin And Metalloprotease” (ADAM) family of sheddases: Physiological and cellular functions

(2008) Karina Reiss et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY