Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity
出版年份 2012 全文链接
标题
Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity
作者
关键词
-
出版物
EXPERT REVIEWS IN MOLECULAR MEDICINE
Volume 14, Issue -, Pages -
出版商
Cambridge University Press (CUP)
发表日期
2012-07-26
DOI
10.1017/erm.2012.10
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Amyloid State of Proteins in Human Diseases
- (2012) David Eisenberg et al. CELL
- The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop
- (2012) Andreas B Schmid et al. EMBO JOURNAL
- Intrinsically disordered proteins and novel strategies for drug discovery
- (2012) Vladimir N. Uversky Expert Opinion on Drug Discovery
- Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
- (2012) Jolanta Grembecka et al. Nature Chemical Biology
- Agonism/antagonism switching in allosteric ensembles
- (2012) H. N. Motlagh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
- (2012) T. Maurer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural biology and drug discovery for protein–protein interactions
- (2012) Harry Jubb et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Macrocycles That Inhibit the Binding between Heat Shock Protein 90 and TPR-Containing Proteins
- (2011) Veronica C. Ardi et al. ACS Chemical Biology
- Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism
- (2011) Laura F. Silvian et al. ACS Chemical Biology
- Structure-Based Discovery of a Novel Inhibitor Targeting the β-Catenin/Tcf4 Interaction
- (2011) Wang Tian et al. BIOCHEMISTRY
- The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones
- (2011) Jing Li et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Hot Spots for Allosteric Regulation on Protein Surfaces
- (2011) Kimberly A. Reynolds et al. CELL
- Interactome Networks and Human Disease
- (2011) Marc Vidal et al. CELL
- Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition
- (2011) Lisa von Kleist et al. CELL
- Insight into Amyloid Structure Using Chemical Probes
- (2011) Ashley A. Reinke et al. Chemical Biology & Drug Design
- Chemical Screens against a Reconstituted Multiprotein Complex: Myricetin Blocks DnaJ Regulation of DnaK through an Allosteric Mechanism
- (2011) Lyra Chang et al. CHEMISTRY & BIOLOGY
- Context-Based Identification of Protein-Protein Interfaces and “Hot-Spot” Residues
- (2011) Tim Geppert et al. CHEMISTRY & BIOLOGY
- Branched Peptides for the Modulation of Protein-Protein Interactions: More Arms are Better than One?
- (2011) M. Ruvo et al. CURRENT MEDICINAL CHEMISTRY
- Chemical and structural lessons from recent successes in protein–protein interaction inhibition (2P2I)
- (2011) Xavier Morelli et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies
- (2011) Yoshinari Miyata et al. Future Medicinal Chemistry
- Modulating Protein–Protein Interactions with Small Molecules: The Importance of Binding Hotspots
- (2011) Ratna Rajesh Thangudu et al. JOURNAL OF MOLECULAR BIOLOGY
- An orthosteric inhibitor of the Ras-Sos interaction
- (2011) Anupam Patgiri et al. Nature Chemical Biology
- Heat shock protein 70 kDa chaperone/DnaJ cochaperone complex employs an unusual dynamic interface
- (2011) A. Ahmad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information
- (2011) M. C. Good et al. SCIENCE
- Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors
- (2010) Andrea L. Jochim et al. ACS Chemical Biology
- Binding of a Small Molecule at a Protein–Protein Interface Regulates the Chaperone Activity of Hsp70–Hsp40
- (2010) Susanne Wisén et al. ACS Chemical Biology
- Nucleating the Assembly of Macromolecular Complexes
- (2010) Kimberly J. Peterson-Kaufman et al. CHEMBIOCHEM
- Homodimeric Enzymes as Drug Targets
- (2010) D. Cardinale et al. CURRENT MEDICINAL CHEMISTRY
- Enhancements of screening collections to address areas of unmet medical need: an industry perspective
- (2010) David H Drewry et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy
- (2010) James R Porter et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Discovery of Modulators of Protein-Protein Interactions: Current Approaches and Limitations
- (2010) Lidio M.C. Meireles et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Transcriptional Switches: Chemical Approaches to Gene Regulation
- (2010) Lori W. Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ATPases as Drug Targets: Insights from Heat Shock Proteins 70 and 90
- (2010) Andrew J. Massey JOURNAL OF MEDICINAL CHEMISTRY
- Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target
- (2010) Christopher G. Evans et al. JOURNAL OF MEDICINAL CHEMISTRY
- Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication
- (2010) Frauke Christ et al. Nature Chemical Biology
- The HSP70 chaperone machinery: J proteins as drivers of functional specificity
- (2010) Harm H. Kampinga et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Atomic Analysis of Protein-Protein Interfaces with Known Inhibitors: The 2P2I Database
- (2010) Raphaël Bourgeas et al. PLoS One
- Cellular strategies for the assembly of molecular machines
- (2010) Ashwin Chari et al. TRENDS IN BIOCHEMICAL SCIENCES
- Computational Analysis of Protein Hotspots
- (2010) Chao-Yie Yang et al. ACS Medicinal Chemistry Letters
- Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors
- (2009) Sara J. Buhrlage et al. ACS Chemical Biology
- Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90-Cdc37, a Kinome Chaperone-Cochaperone, by Triterpene Celastrol
- (2009) Sridhar Sreeramulu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Atomic Interactions and Profile of Small Molecules Disrupting Protein-Protein Interfaces: the TIMBAL Database
- (2009) Alícia P. Higueruelo et al. Chemical Biology & Drug Design
- The road less traveled: modulating signal transduction enzymes by inhibiting their protein–protein interactions
- (2009) Michelle R Arkin et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Alternate Strategies of Hsp90 Modulation for the Treatment of Cancer and Other Diseases
- (2009) Gary Brandt et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Pharmacological Targeting of the Hsp70 Chaperone
- (2009) Srikanth Patury et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Characterization of Celastrol to Inhibit Hsp90 and Cdc37 Interaction
- (2009) Tao Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Affinities between the Binding Partners of the HIV-1 Integrase Dimer-Lens Epithelium-derived Growth Factor (IN Dimer-LEDGF) Complex
- (2009) Manuel Tsiang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Covalent Modifiers: An Orthogonal Approach to Drug Design
- (2009) Michele H. Potashman et al. JOURNAL OF MEDICINAL CHEMISTRY
- Allostery in Hsp70 Chaperones Is Transduced by Subdomain Rotations
- (2009) Akash Bhattacharya et al. JOURNAL OF MOLECULAR BIOLOGY
- Identifying Modulators of Protein−Protein Interactions Using Photonic Crystal Biosensors
- (2009) James T. Heeres et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A Small Molecule Inhibitor of Inducible Heat Shock Protein 70
- (2009) J. I-Ju Leu et al. MOLECULAR CELL
- A synergistic small-molecule combination directly eradicates diverse prion strain structures
- (2009) Blake E Roberts et al. Nature Chemical Biology
- The rise of fragment-based drug discovery
- (2009) Christopher W. Murray et al. Nature Chemistry
- Converging concepts of protein folding in vitro and in vivo
- (2009) F Ulrich Hartl et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Trapping Moving Targets with Small Molecules
- (2009) G. M. Lee et al. SCIENCE
- A Novel Class of Small Molecule Inhibitors of Hsp90
- (2008) Fang Yi et al. ACS Chemical Biology
- Expanding the repertoire of small molecule transcriptional activation domains
- (2008) Ryan J. Casey et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Principles of Protein−Protein Interactions: What are the Preferred Ways For Proteins To Interact?
- (2008) Ozlem Keskin et al. CHEMICAL REVIEWS
- Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide- binding Pocket
- (2008) Alison Donnelly et al. CURRENT MEDICINAL CHEMISTRY
- The Human Cdc37·Hsp90 Complex Studied by Heteronuclear NMR Spectroscopy
- (2008) Sridhar Sreeramulu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Cell-penetrating Helical Peptide as a Potential HIV-1 Inhibitor
- (2008) Hongtao Zhang et al. JOURNAL OF MOLECULAR BIOLOGY
- From hatching to dispatching: the multiple cellular roles of the Hsp70 molecular chaperone machinery
- (2008) Eirini Meimaridou et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- A General and Rapid Cell-Free Approach for the Interrogation of Protein−Protein, Protein−DNA, and Protein−RNA Interactions and their Antagonists Utilizing Split-Protein Reporters
- (2008) Jason R. Porter et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structural identification of the pathway of long-range communication in an allosteric enzyme
- (2008) P. S. Gandhi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
- (2008) S. Shangary et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK
- (2007) Lyra Chang et al. ANALYTICAL BIOCHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More