Effector mechanisms of influenza-specific antibodies: neutralization and beyond

Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies

(2018) Yao-Qing Chen et al.   CELL

From Original Antigenic Sin to the Universal Influenza Virus Vaccine

(2018) Carole Henry et al.   TRENDS IN IMMUNOLOGY

Towards a universal influenza vaccine: different approaches for one goal

(2018) Giuseppe A. Sautto et al.   Virology Journal

NAction! How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines?

(2018) Florian Krammer et al.   mBio

How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin

(2018) Michael B. Doud et al.   Nature Communications

Strategies to induce broadly protective antibody responses to viral glycoproteins

(2017) F Krammer   Expert Review of Vaccines

Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice

(2017) Christine K. Wong et al.   JOURNAL OF IMMUNOLOGY

Dissection of Epitope-Specific Mechanisms of Neutralization of Influenza Virus by Intact IgG and Fab Fragments

(2017) James A. Williams et al.   JOURNAL OF VIROLOGY

Influenza

(2017) Catharine Paules et al.   LANCET

Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin

(2017) Madhusudan Rajendran et al.   mBio

Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice

(2017) Wenqian He et al.   Nature Communications

Antibody-dependent cellular cytotoxicity and influenza virus

(2017) Hillary A Vanderven et al.   Current Opinion in Virology

Tackling influenza with broadly neutralizing antibodies

(2017) Davide Corti et al.   Current Opinion in Virology

Synergy between the classical and alternative pathways of complement is essential for conferring effective protection against the pandemic influenza A(H1N1) 2009 virus infection

(2017) Ajitanuj Rattan et al.   PLoS Pathogens

Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain

(2017) Christopher S. Anderson et al.   Scientific Reports

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

(2016) M. Gordon Joyce et al.   CELL

Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection

(2016) Carole J. Henry Dunand et al.   Cell Host & Microbe

Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?

(2016) Karlynn E Neu et al.   CURRENT OPINION IN IMMUNOLOGY

The life cycle of phagosomes: formation, maturation, and resolution

(2016) Roni Levin et al.   IMMUNOLOGICAL REVIEWS

A comparison of hemagglutination inhibition and neutralization assays for characterizing immunity to seasonal influenza A

(2016) Shaun Truelove et al.   Influenza and Other Respiratory Viruses

Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection

(2016) David J. DiLillo et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation and Protective Ability of Influenza Virus–Specific Antibody-Dependent Cellular Cytotoxicity in Humans Elicited by Vaccination, Natural Infection, and Experimental Challenge

(2016) Sinthujan Jegaskanda et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination

(2016) Jiwon Lee et al.   NATURE MEDICINE

Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact

(2016) Paul E. Leon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus

(2016) Wenqian He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner

(2016) Caitlin E. Mullarkey et al.   mBio

Two Escape Mechanisms of Influenza A Virus to a Broadly Neutralizing Stalk-Binding Antibody

(2016) Ning Chai et al.   PLoS Pathogens

Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection

(2016) Gene S. Tan et al.   PLoS Pathogens

HA Antibody-Mediated FcγRIIIa Activity Is Both Dependent on FcR Engagement and Interactions between HA and Sialic Acids

(2016) Freek Cox et al.   Frontiers in Immunology

Heterosubtypic T-Cell Immunity to Influenza in Humans: Challenges for Universal T-Cell Influenza Vaccines

(2016) Saranya Sridhar   Frontiers in Immunology

What Lies Beneath: Antibody Dependent Natural Killer Cell Activation by Antibodies to Internal Influenza Virus Proteins

(2016) Hillary A. Vanderven et al.   EBioMedicine

Influenza-Specific Antibody-Dependent Phagocytosis

(2016) Fernanda Ana-Sosa-Batiz et al.   PLoS One

The role of Fc–FcγR interactions in IgG-mediated microbial neutralization

(2015) Stylianos Bournazos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibody to Influenza Virus Neuraminidase: An Independent Correlate of Protection

(2015) Arnold S. Monto et al.   JOURNAL OF INFECTIOUS DISEASES

Cross-Reactive Neuraminidase-Inhibiting Antibodies Elicited by Immunization with Recombinant Neuraminidase Proteins of H5N1 and Pandemic H1N1 Influenza A Viruses

(2015) Wen-Chun Liu et al.   JOURNAL OF VIROLOGY

Advances in the development of influenza virus vaccines

(2015) Florian Krammer et al.   NATURE REVIEWS DRUG DISCOVERY

Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody

(2015) Xiaoli Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus

(2015) Ying Wu et al.   Nature Communications

Structural characterization of a protective epitope spanning A(H1N1)pdm09 influenza virus neuraminidase monomers

(2015) Hongquan Wan et al.   Nature Communications

A Human Anti-M2 Antibody Mediates Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Cytokine Secretion by Resting and Cytokine-Preactivated Natural Killer (NK) Cells

(2015) Venkateswara R. Simhadri et al.   PLoS One

Phagocytosis: receptors, signal integration, and the cytoskeleton

(2014) Spencer A. Freeman et al.   IMMUNOLOGICAL REVIEWS

A Novel Role for Non-Neutralizing Antibodies against Nucleoprotein in Facilitating Resistance to Influenza Virus

(2014) D. M. Carragher et al.   JOURNAL OF IMMUNOLOGY

A Broadly Neutralizing Human Monoclonal Antibody Directed against a Novel Conserved Epitope on the Influenza Virus H3 Hemagglutinin Globular Head

(2014) E. Benjamin et al.   JOURNAL OF VIROLOGY

Characterization of a Broadly Neutralizing Monoclonal Antibody That Targets the Fusion Domain of Group 2 Influenza A Virus Hemagglutinin

(2014) G. S. Tan et al.   JOURNAL OF VIROLOGY

Biological and Protective Properties of Immune Sera Directed to the Influenza Virus Neuraminidase

(2014) Stefan J. Halbherr et al.   JOURNAL OF VIROLOGY

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

(2014) David J DiLillo et al.   NATURE MEDICINE

Enabling the 'host jump': structural determinants of receptor-binding specificity in influenza A viruses

(2014) Yi Shi et al.   NATURE REVIEWS MICROBIOLOGY

Relating influenza virus membrane fusion kinetics to stoichiometry of neutralizing antibodies at the single-particle level

(2014) Jason J. Otterstrom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phagocytosis

(2014) Ann M. Carias et al.   Current Opinion in HIV and AIDS

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

Broadly neutralizing antibodies against influenza viruses

(2013) Nick S. Laursen et al.   ANTIVIRAL RESEARCH

In VitroAssessment of the Immunological Significance of a Human Monoclonal Antibody Directed to the Influenza A Virus Nucleoprotein

(2013) Rogier Bodewes et al.   Clinical and Vaccine Immunology

H3N2 Influenza Virus Infection Induces Broadly Reactive Hemagglutinin Stalk Antibodies in Humans and Mice

(2013) I. Margine et al.   JOURNAL OF VIROLOGY

Mechanisms of Hemagglutinin Targeted Influenza Virus Neutralization

(2013) Boerries Brandenburg et al.   PLoS One

A common solution to group 2 influenza virus neutralization

(2013) R. H. E. Friesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New World Bats Harbor Diverse Influenza A Viruses

(2013) Suxiang Tong et al.   PLoS Pathogens

Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates

(2013) Tijana Ivanovic et al.   eLife

Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium

(2013) Eva Böttcher-Friebertshäuser et al.   Pathogens and Disease

Contribution of antibody production against neuraminidase to the protection afforded by influenza vaccines

(2012) Glendie Marcelin et al.   REVIEWS IN MEDICAL VIROLOGY

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

Comparison of complement dependent lytic, hemagglutination inhibition and microneutralization antibody responses in influenza vaccinated individuals

(2012) Mary Dawn T. Co et al.   Human Vaccines & Immunotherapeutics

Structural basis of influenza virus neutralization

(2011) Thomas Han et al.   Annals of the New York Academy of Sciences

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

(2011) Jens Wrammert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Complement-Dependent Lysis of Influenza A Virus-Infected Cells by Broadly Cross-Reactive Human Monoclonal Antibodies

(2011) M. Terajima et al.   JOURNAL OF VIROLOGY

Architecture of a nascent viral fusion pore

(2010) Kelly K Lee   EMBO JOURNAL

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

(2010) J. Steel et al.   mBio

Going Adaptive

(2009) Nadia Danilova et al.   Annals of the New York Academy of Sciences

Activating and inhibitory Fcγ receptors in immunotherapy: being the actor or being the target

(2009) Riad Abès et al.   Expert Review of Clinical Immunology

Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA

(2009) J. Zhang et al.   JOURNAL OF GENERAL VIROLOGY

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift

(2009) S. E. Hensley et al.   SCIENCE

Therapeutic potential of a fully human monoclonal antibody against influenza A virus M2 protein

(2008) R WANG et al.   ANTIVIRAL RESEARCH