Influenza vaccines: T-cell responses deserve more attention

Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants

(2012) Colleen Olive   Expert Review of Vaccines

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Early Priming Minimizes the Age-Related Immune Compromise of CD8+ T Cell Diversity and Function

(2012) Sophie A. Valkenburg et al.   PLoS Pathogens

Influenza A Virus Infection of Human Primary Dendritic Cells Impairs Their Ability to Cross-Present Antigen to CD8 T Cells

(2012) Anna Smed-Sörensen et al.   PLoS Pathogens

Effect on Cellular and Humoral Immune Responses of the AS03 Adjuvant System in an A/H1N1/2009 Influenza Virus Vaccine Administered to Adults during Two Randomized Controlled Trials

(2011) François Roman et al.   Clinical and Vaccine Immunology

Systematic review of clinical and epidemiological features of the pandemic influenza A (H1N1) 2009

(2011) Gulam Khandaker et al.   Influenza and Other Respiratory Viruses

Inflammatory chemokine receptors regulate CD8+T cell contraction and memory generation following infection

(2011) Jacob E. Kohlmeier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cross-protective immunity against influenza pH1N1 2009 viruses induced by seasonal influenza A (H3N2) virus is mediated by virus-specific T-cells

(2011) M. L. B. Hillaire et al.   JOURNAL OF GENERAL VIROLOGY

Influenza Hemagglutination-Inhibition Antibody Titer as a Correlate of Vaccine-Induced Protection

(2011) Suzanne E. Ohmit et al.   JOURNAL OF INFECTIOUS DISEASES

Live and Inactivated Influenza Vaccines Induce Similar Humoral Responses, but Only Live Vaccines Induce Diverse T-Cell Responses in Young Children

(2011) Daniel F. Hoft et al.   JOURNAL OF INFECTIOUS DISEASES

Vaccination against Seasonal Influenza A/H3N2 Virus Reduces the Induction of Heterosubtypic Immunity against Influenza A/H5N1 Virus Infection in Ferrets

(2011) R. Bodewes et al.   JOURNAL OF VIROLOGY

DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials

(2011) Julie E Ledgerwood et al.   LANCET INFECTIOUS DISEASES

Hemagglutination Inhibition Antibody Titers as a Correlate of Protection for Inactivated Influenza Vaccines in Children

(2011) Steven Black et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Influenza A Virus Hemagglutinin Antibody Escape Promotes Neuraminidase Antigenic Variation and Drug Resistance

(2011) Scott E. Hensley et al.   PLoS One

Safety and immunogenicity of two different doses of a Vero cell-derived, whole virus clade 2 H5N1 (A/Indonesia/05/2005) influenza vaccine

(2011) Paul A. Tambyah et al.   VACCINE

Superior Immunogenicity of Inactivated Whole Virus H5N1 Influenza Vaccine is Primarily Controlled by Toll-like Receptor Signalling

(2011) Felix Geeraedts et al.   PLoS Pathogens

Cross-Reactive T Cells Are Involved in Rapid Clearance of 2009 Pandemic H1N1 Influenza Virus in Nonhuman Primates

(2011) Jason T. Weinfurter et al.   PLoS Pathogens

Potent CD8+ T-Cell Immunogenicity in Humans of a Novel Heterosubtypic Influenza A Vaccine, MVA-NP+M1

(2010) T. K. Berthoud et al.   CLINICAL INFECTIOUS DISEASES

H5N1 Influenza Vaccine Formulated with AS03A Induces Strong Cross-Reactive and Polyfunctional CD4 T-Cell Responses

(2010) Philippe Moris et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The route of priming influences the ability of respiratory virus–specific memory CD8+T cells to be activated by residual antigen

(2010) Shiki Takamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evaluation of a modified vaccinia virus Ankara (MVA)-based candidate pandemic influenza A/H1N1 vaccine in the ferret model

(2010) J. H. C. M. Kreijtz et al.   JOURNAL OF GENERAL VIROLOGY

A Whole Virus Pandemic Influenza H1N1 Vaccine Is Highly Immunogenic and Protective in Active Immunization and Passive Protection Mouse Models

(2010) Otfried Kistner et al.   PLoS One

Cross-reactive CD8+T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses

(2010) Stephanie Gras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus

(2010) B. Manicassamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The need for quadrivalent vaccine against seasonal influenza

(2010) Robert B. Belshe   VACCINE

Evaluation of the cellular immune responses induced by a non-adjuvanted inactivated whole virus A/H5N1/VN/1203 pandemic influenza vaccine in humans

(2010) Brian A. Crowe et al.   VACCINE

Prior infection of pigs with swine influenza viruses is a barrier to infection with avian influenza viruses

(2010) Annebel De Vleeschauwer et al.   VETERINARY MICROBIOLOGY

Current status and progress of prepandemic and pandemic influenza vaccine development

(2009) Isabel Leroux-Roels et al.   Expert Review of Vaccines

Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments

(2009) Michael Schotsaert et al.   Expert Review of Vaccines

Defective Ribosomal Products Are the Major Source of Antigenic Peptides Endogenously Generated from Influenza A Virus Neuraminidase

(2009) B. P. Dolan et al.   JOURNAL OF IMMUNOLOGY

Prolonged Influenza Virus Infection during Lymphocytopenia and Frequent Detection of Drug‐Resistant Viruses

(2009) Jairo Gooskens et al.   JOURNAL OF INFECTIOUS DISEASES

Yearly influenza vaccinations: a double-edged sword?

(2009) Rogier Bodewes et al.   LANCET INFECTIOUS DISEASES

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

(2009) Jie Sun et al.   NATURE MEDICINE

Poverty, Wealth, and Access to Pandemic Influenza Vaccines

(2009) Tadataka Yamada   NEW ENGLAND JOURNAL OF MEDICINE

Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus

(2009) Kathy Hancock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccination against Human Influenza A/H3N2 Virus Prevents the Induction of Heterosubtypic Immunity against Lethal Infection with Avian Influenza A/H5N1 Virus

(2009) Rogier Bodewes et al.   PLoS One

Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population

(2009) J. A. Greenbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels

(2009) G. Galli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prior infection with an H1N1 swine influenza virus partially protects pigs against a low pathogenic H5N1 avian influenza virus

(2009) Kristien Van Reeth et al.   VACCINE

Time Lines of Infection and Disease in Human Influenza: A Review of Volunteer Challenge Studies

(2008) Fabrice Carrat et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Pre-clinical development of cell culture (Vero)-derived H5N1 pandemic vaccines

(2008) M. Keith Howard et al.   BIOLOGICAL CHEMISTRY

Correlation of Cellular Immune Responses with Protection against Culture-Confirmed Influenza Virus in Young Children

(2008) B. D. Forrest et al.   Clinical and Vaccine Immunology

The Chemokine Receptor CCR5 Plays a Key Role in the Early Memory CD8+ T Cell Response to Respiratory Virus Infections

(2008) Jacob E. Kohlmeier et al.   IMMUNITY

Better Influenza Vaccines for Older People: What Will It Take?

(2008) Janet E. McElhaney et al.   JOURNAL OF INFECTIOUS DISEASES

Recombinant Modified Vaccinia Virus Ankara Expressing the Hemagglutinin Gene Confers Protection against Homologous and Heterologous H5N1 Influenza Virus Infections in Macaques

(2008) J. H. C. M. Kreijtz et al.   JOURNAL OF INFECTIOUS DISEASES

Cross-Recognition of Avian H5N1 Influenza Virus by Human Cytotoxic T-Lymphocyte Populations Directed to Human Influenza A Virus

(2008) J. H. C. M. Kreijtz et al.   JOURNAL OF VIROLOGY

A Clinical Trial of a Whole-Virus H5N1 Vaccine Derived from Cell Culture

(2008) Hartmut J. Ehrlich et al.   NEW ENGLAND JOURNAL OF MEDICINE