The role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets

Differential Expression and Molecular Associations of Syk in Systemic Lupus Erythematosus T Cells

(2014) S. Krishnan et al.   JOURNAL OF IMMUNOLOGY

Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population

(2014) Chieko Kyogoku et al.   Modern Rheumatology

Suppression of Glomerulonephritis in Lupus-Prone NZB × NZW Mice by RN486, a Selective Inhibitor of Bruton's Tyrosine Kinase

(2013) Paola Mina-Osorio et al.   ARTHRITIS AND RHEUMATISM

Lck Availability during Thymic Selection Determines the Recognition Specificity of the T Cell Repertoire

(2013) François Van Laethem et al.   CELL

T Cell-Derived Protein S Engages TAM Receptor Signaling in Dendritic Cells to Control the Magnitude of the Immune Response

(2013) Eugenio A. Carrera Silva et al.   IMMUNITY

Ibrutinib and novel BTK inhibitors in clinical development

(2013) Akintunde Akinleye et al.   Journal of Hematology & Oncology

Bruton's Tyrosine Kinase Is Required for Apoptotic Cell Uptake via Regulating the Phosphorylation and Localization of Calreticulin

(2013) J. C. Byrne et al.   JOURNAL OF IMMUNOLOGY

The Autoimmunity Risk Variant LYP-W620 Cooperates with CSK in the Regulation of TCR Signaling

(2013) María Luisa de la Puerta et al.   PLoS One

Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling

(2013) Alexandros P. Grammatikos et al.   PLoS One

Bruton’s Tyrosine Kinase Mediates the Synergistic Signalling between TLR9 and the B Cell Receptor by Regulating Calcium and Calmodulin

(2013) Elaine F. Kenny et al.   PLoS One

Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation

(2013) C. Lamagna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitors of BTK and ITK: State of the New Drugs for Cancer, Autoimmunity and Inflammatory Diseases

(2013) L. Vargas et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity

(2013) Pedro Recarte-Pelz et al.   ARTHRITIS RESEARCH & THERAPY

Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity

(2013) Gaetano Zizzo et al.   ARTHRITIS RESEARCH & THERAPY

Ibrutinib (PCI-32765), the First BTK (Bruton’s Tyrosine Kinase) Inhibitor in Clinical Trials

(2013) Jennifer R. Brown   Current Hematologic Malignancy Reports

Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis

(2012) B. T. van den Brand et al.   ARTHRITIS AND RHEUMATISM

Platelet-derived growth factors and their receptors: Structural and functional perspectives

(2012) Po-Han Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice

(2012) L. P. Kil et al.   BLOOD

Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state

(2012) Sebastian Königsberger et al.   EMBO JOURNAL

Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis

(2012) Young Ho Lee et al.   INFLAMMATION RESEARCH

Regulation of the Src Family Kinases by Csk

(2012) Masato Okada   International Journal of Biological Sciences

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

(2012) Nataly Manjarrez-Orduño et al.   NATURE GENETICS

Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus

(2012) Jack Hutcheson et al.   ARTHRITIS RESEARCH & THERAPY

Lack of Association of TYK2 Gene Polymorphisms in Chinese Patients with Systemic Lupus Erythematosus

(2011) P. LI et al.   JOURNAL OF RHEUMATOLOGY

Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis

(2011) Jun Wu et al.   ARTHRITIS RESEARCH & THERAPY

An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: A three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents

(2010) Mark C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Lack of Interaction Between Systemic Lupus Erythematosus-associated Polymorphisms in TYK2 and IRF5

(2010) M. SUAREZ-GESTAL et al.   JOURNAL OF RHEUMATOLOGY

TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus

(2010) Chang-Hee Suh et al.   ARTHRITIS RESEARCH & THERAPY

Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus

(2009) Tiina M. Järvinen et al.   EXPERIMENTAL DERMATOLOGY

Genetic associations of LYN with systemic lupus erythematosus

(2009) R Lu et al.   GENES AND IMMUNITY

T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

(2009) Robert J. Salmond et al.   IMMUNOLOGICAL REVIEWS

Bruton’s tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

(2009) Abdalla J. Mohamed et al.   IMMUNOLOGICAL REVIEWS

Fyn and CD70 Expression in CD4+ T Cells from Patients with Systemic Lupus Erythematosus

(2009) A. KOZLOWSKA et al.   JOURNAL OF RHEUMATOLOGY

Evidence for Genetic Association and Interaction Between the TYK2 and IRF5 Genes in Systemic Lupus Erythematosus

(2009) A. HELLQUIST et al.   JOURNAL OF RHEUMATOLOGY

An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus

(2008) Frances Rena Bahjat et al.   ARTHRITIS AND RHEUMATISM

Is there a future for small molecule drugs in the treatment of rheumatic diseases?

(2008) Joanna Stanczyk et al.   CURRENT OPINION IN RHEUMATOLOGY

Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells

(2008) Kristina E. Halcomb et al.   MOLECULAR IMMUNOLOGY

Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth

(2008) Shigeru Yamada et al.   NEUROREPORT

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE