Immunodiscordant responses to HAART – mechanisms and consequences

Restoration of the CD4 T Cell Compartment after Long-Term Highly Active Antiretroviral Therapy without Phenotypical Signs of Accelerated Immunological Aging

(2014) N. Vrisekoop et al.   JOURNAL OF IMMUNOLOGY

NKp44L expression on CD4+ T cells is associated with impaired immunological recovery in HIV-infected patients under highly active antiretroviral therapy

(2013) Alexis Sennepin et al.   AIDS

The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial

(2013) P. W. Hunt et al.   BLOOD

Interleukin-7 promotes HIV persistence during antiretroviral therapy

(2013) C. Vandergeeten et al.   BLOOD

Assessing main death pathways in T lymphocytes from HIV infected individuals

(2013) Marta Massanella et al.   CYTOMETRY PART A

A Dendritic Cell-Based Vaccine Elicits T Cell Responses Associated with Control of HIV-1 Replication

(2013) F. Garcia et al.   Science Translational Medicine

Raltegravir intensification shows differing effects on CD8 and CD4 T cells in HIV-infected HAART-suppressed individuals with poor CD4 T-cell recovery

(2012) Marta Massanella et al.   AIDS

The association of CD4+ T-cell counts and cardiovascular risk in treated HIV disease

(2012) Jennifer E. Ho et al.   AIDS

Differential alterations of the CD4 and CD8 T cell subsets in HIV-infected patients on highly active antiretroviral therapy with low CD4 T cell restoration

(2012) G. Mendez-Lagares et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Naive T cells are dispensable for memory CD4 + T cell homeostasis in progressive simian immunodeficiency virus infection

(2012) Afam A. Okoye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Severe Immune Dysregulation Affects CD4+CD25hiFoxP3+ Regulatory T Cells in HIV-Infected Patients With Low-level CD4 T-Cell Repopulation Despite Suppressive Highly Active Antiretroviral Therapy

(2012) Gema Méndez-Lagares et al.   JOURNAL OF INFECTIOUS DISEASES

Thymic tissue is not evident on high-resolution computed tomography and [18F]Fluoro-deoxy-glucose positron emission tomography scans of aviraemic HIV patients with poor recovery of CD4+ T cells

(2011) Sara Tanaskovic et al.   AIDS

Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients

(2011) Victor Appay et al.   AIDS

Long-term complications in patients with poor immunological recovery despite virological successful HAART in Dutch ATHENA cohort

(2011) Steven F.L. van Lelyveld et al.   AIDS

Hepatitis C coinfection enhances sensitization of CD4+ T-cells towards Fas-induced apoptosis in viraemic and HAART-controlled HIV-1-positive patients

(2011) Christian Körner et al.   ANTIVIRAL THERAPY

Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: a randomized 48-week study

(2011) Josep M Llibre et al.   ANTIVIRAL THERAPY

Decreases in IL-7 levels during antiretroviral treatment of HIV infection suggest a primary mechanism of receptor-mediated clearance

(2011) J. N. Hodge et al.   BLOOD

Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders

(2011) S. Piconi et al.   BLOOD

High T-cell immune activation and immune exhaustion among individuals with suboptimal CD4 recovery after 4 years of antiretroviral therapy in an African cohort

(2011) Damalie Nakanjako et al.   BMC INFECTIOUS DISEASES

CD4 and CD8 T Cell Immune Activation during Chronic HIV Infection: Roles of Homeostasis, HIV, Type I IFN, and IL-7

(2011) M. Catalfamo et al.   JOURNAL OF IMMUNOLOGY

A Randomized, Controlled Trial of Raltegravir Intensification in Antiretroviral-treated, HIV-infected Patients with a Suboptimal CD4+ T Cell Response

(2011) Hiroyu Hatano et al.   JOURNAL OF INFECTIOUS DISEASES

Intensification of Antiretroviral Therapy With Raltegravir or Addition of Hyperimmune Bovine Colostrum in HIV-Infected Patients With Suboptimal CD4+ T-Cell Response: A Randomized Controlled Trial

(2011) Helen Byakwaga et al.   JOURNAL OF INFECTIOUS DISEASES

Valganciclovir Reduces T Cell Activation in HIV-Infected Individuals With Incomplete CD4+ T Cell Recovery on Antiretroviral Therapy

(2011) Peter W. Hunt et al.   JOURNAL OF INFECTIOUS DISEASES

Immunologic Failure Despite Suppressive Antiretroviral Therapy Is Related to Activation and Turnover of Memory CD4 Cells

(2011) Michael M. Lederman et al.   JOURNAL OF INFECTIOUS DISEASES

Skewed T-cell maturation and function in HIV-infected patients failing CD4+ recovery upon long-term virologically suppressive HAART

(2010) Giulia Marchetti et al.   AIDS

Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy

(2010) Steven A Yukl et al.   AIDS

CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART

(2010) Marta Massanella et al.   AIDS

Treatment with Recombinant Growth Hormone Is Associated with Modest Improvement in CD4 Lymphocyte Reconstitution in HIV-Infected Persons on Antiretroviral Therapy: Results of ACTG A5174

(2010) Kimberly Smith et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV Infection, Inflammation, Immunosenescence, and Aging

(2010) Steven G. Deeks   Annual Review of Medicine

Nadir CD4 T Cell Count as Predictor and High CD4 T Cell Intrinsic Apoptosis as Final Mechanism of Poor CD4 T Cell Recovery in Virologically Suppressed HIV‐Infected Patients: Clinical Implications

(2010) Eugènia Negredo et al.   CLINICAL INFECTIOUS DISEASES

T-Cell Dysfunction in HIV-1-Infected Patients With Impaired Recovery of CD4 Cells Despite Suppression of Viral Replication

(2010) Christian Erikstrup et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

A CD4+ Cell Count

(2010) Mona R Loutfy et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Identification of PD-1 as a Unique Marker for Failing Immune Reconstitution in HIV-1–Infected Patients on Treatment

(2010) Katharina Grabmeier-Pfistershammer et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

(2010) Julie R. Brahmer et al.   JOURNAL OF CLINICAL ONCOLOGY

Differences in HIV Burden and Immune Activation within the Gut of HIV‐Positive Patients Receiving Suppressive Antiretroviral Therapy

(2010) Steven A. Yukl et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects

(2010) Maria J Buzón et al.   NATURE MEDICINE

The Effect of Raltegravir Intensification on Low-level Residual Viremia in HIV-Infected Patients on Antiretroviral Therapy: A Randomized Controlled Trial

(2010) Rajesh T. Gandhi et al.   PLOS MEDICINE

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

(2009) I. Sereti et al.   BLOOD

The Absence of CD4+T Cell Count Recovery Despite Receipt of Virologically Suppressive Highly Active Antiretroviral Therapy: Clinical Risk, Immunological Gaps, and Therapeutic Options

(2009) Lidia Gazzola et al.   CLINICAL INFECTIOUS DISEASES

Incomplete Peripheral CD4+Cell Count Restoration in HIV‐Infected Patients Receiving Long‐Term Antiretroviral Treatment

(2009) Colleen F. Kelley et al.   CLINICAL INFECTIOUS DISEASES

Incomplete Reconstitution of T Cell Subsets on Combination Antiretroviral Therapy in the AIDS Clinical Trials Group Protocol 384

(2009) Gregory K. Robbins et al.   CLINICAL INFECTIOUS DISEASES

Effects of HCV co-infection on apoptosis of CD4+T-cells in HIV-positive patients

(2009) Christian Körner et al.   CLINICAL SCIENCE

Risk Factors, CD4 Long-Term Evolution and Mortality of HIV-Infected Patients who Persistently Maintain Low CD4 Counts, Despite Virological Response to HAART

(2009) Yolanda Pacheco et al.   CURRENT HIV RESEARCH

Poor Initial CD4+ Recovery With Antiretroviral Therapy Prolongs Immune Depletion and Increases Risk for AIDS and Non-AIDS Diseases

(2009) Jason V Baker et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Premature immunosenescence in HIV-infected patients on highly active antiretroviral therapy with low-level CD4 T cell repopulation

(2009) S. Molina-Pinelo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral‐Treated HIV Infection

(2009) Wei Jiang et al.   JOURNAL OF INFECTIOUS DISEASES

Risk of Myocardial Infarction in Patients with HIV Infection Exposed to Specific Individual Antiretroviral Drugs from the 3 Major Drug Classes: The Data Collection on Adverse Events of Anti‐HIV Drugs (D:A:D) Study

(2009) Signe Westring Worm et al.   JOURNAL OF INFECTIOUS DISEASES

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Interleukin-2 Therapy in Patients with HIV Infection

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

HIV-1 Residual Viremia Correlates with Persistent T-Cell Activation in Poor Immunological Responders to Combination Antiretroviral Therapy

(2009) Maud Mavigner et al.   PLoS One

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

(2009) H. Tsukamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy

(2008) Giulia Marchetti et al.   AIDS

Increased levels of regulatory T cells (Tregs) in human immunodeficiency virus-infected patients after 5 years of highly active anti-retroviral therapy may be due to increased thymic production of naive Tregs

(2008) L. Kolte et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Rate of Comorbidities Not Related to HIV Infection or AIDS among HIV‐Infected Patients, by CD4 Cell Count and HAART Use Status

(2008) Richard D. Moore et al.   CLINICAL INFECTIOUS DISEASES

Altered Clonogenic Capability and Stromal Cell Function Characterize Bone Marrow of HIV‐Infected Subjects with Low CD4+T Cell Counts Despite Viral Suppression during HAART

(2008) Antonella Isgrò et al.   CLINICAL INFECTIOUS DISEASES

Patients Characteristics and Clinical Implications of Suboptimal CD4 T-Cell Gains After 1 Year of Successful Antiretroviral Therapy

(2008) Felix Gutierrez et al.   CURRENT HIV RESEARCH

Clinical Outcome of HIV-Infected Antiretroviral-Naive Patients With Discordant Immunologic and Virologic Responses to Highly Active Antiretroviral Therapy

(2008) Ruimin Tan et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection

(2008) Lin Shen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Collagen Deposition Limits Immune Reconstitution in the Gut

(2008) Jacob Estes et al.   JOURNAL OF INFECTIOUS DISEASES

Inferior Clinical Outcome of the CD4+Cell Count–Guided Antiretroviral Treatment Interruption Strategy in the SMART Study: Role of CD4+Cell Counts and HIV RNA Levels during Follow‐up

(2008)   JOURNAL OF INFECTIOUS DISEASES

Persistence of HIV in Gut‐Associated Lymphoid Tissue despite Long‐Term Antiretroviral Therapy

(2008) Tae‐Wook Chun et al.   JOURNAL OF INFECTIOUS DISEASES

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE

HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells

(2008) M. Catalfamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

(2008) S. Palmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intensification of a suppressive HAART regimen increases CD4 counts and decreases CD8+ T-cell activation

(2007) Michael A. Kolber et al.   CLINICAL IMMUNOLOGY

Relationship between T Cell Activation and CD4+T Cell Count in HIV‐Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy

(2007) Peter W. Hunt et al.   JOURNAL OF INFECTIOUS DISEASES

Immune activation and inflammation in HIV-1 infection: causes and consequences

(2007) V Appay et al.   JOURNAL OF PATHOLOGY