Targeting HIV latency: resting memory T cells, hematopoietic progenitor cells and future directions

Functional Adaptation of Nef to the Immune Milieu of HIV-1 Infection In Vivo

(2014) M. J. Lewis et al.   JOURNAL OF IMMUNOLOGY

HIV DNA Subspecies Persist in both Activated and Resting Memory CD4+ T Cells during Antiretroviral Therapy

(2014) J. M. Murray et al.   JOURNAL OF VIROLOGY

CD4+ Memory Stem Cells Are Infected by HIV-1 in a Manner Regulated in Part by SAMHD1 Expression

(2014) C. O. Tabler et al.   JOURNAL OF VIROLOGY

Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial

(2014) Beatriz Grinsztejn et al.   LANCET INFECTIOUS DISEASES

HIV-1 persistence in CD4+ T cells with stem cell–like properties

(2014) Maria J Buzon et al.   NATURE MEDICINE

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Residual Viremia in an RT-SHIV Rhesus Macaque HAART Model Marked by the Presence of a Predominant Plasma Clone and a Lack of Viral Evolution

(2014) Robert C. Kauffman et al.   PLoS One

Expansion of HAART Coverage Is Associated with Sustained Decreases in HIV/AIDS Morbidity, Mortality and HIV Transmission: The “HIV Treatment as Prevention” Experience in a Canadian Setting

(2014) Julio S.G. Montaner et al.   PLoS One

Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy

(2014) A. R. Cillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunologic strategies for HIV-1 remission and eradication

(2014) D. H. Barouch et al.   SCIENCE

HIV-1 Latency in Monocytes/Macrophages

(2014) Amit Kumar et al.   Viruses-Basel

Quantifying Susceptibility of CD4+ Stem Memory T-Cells to Infection by Laboratory Adapted and Clinical HIV-1 Strains

(2014) Jacqueline Flynn et al.   Viruses-Basel

Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART

(2014) Paul W. Denton et al.   PLoS Pathogens

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

(2014) Datsen George Wei et al.   PLoS Pathogens

Thirty Years of HIV and AIDS: Future Challenges and Opportunities

(2013) Carl W. Dieffenbach et al.   ANNALS OF INTERNAL MEDICINE

HIV-1 infection of hematopoietic progenitor cells in vivo in humanized mice

(2013) C. C. Nixon et al.   BLOOD

Interleukin-7 promotes HIV persistence during antiretroviral therapy

(2013) C. Vandergeeten et al.   BLOOD

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

Restrictions to HIV-1 replication in resting CD4+ T lymphocytes

(2013) Xiaoyu Pan et al.   CELL RESEARCH

A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1-Infected Adults on Antiretroviral Therapy

(2013) A. M. Spivak et al.   CLINICAL INFECTIOUS DISEASES

Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce

(2013) Alberto Yáñez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immune interventions in HIV infection

(2013) Guislaine Carcelain et al.   IMMUNOLOGICAL REVIEWS

Dynamics of CD8 T-Cell Activation After Discontinuation of HIV Treatment Intensification

(2013) Marta Massanella et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Plasma Viremia and Cellular HIV-1 DNA Persist Despite Autologous Hematopoietic Stem Cell Transplantation for HIV-Related Lymphoma

(2013) Anthony R. Cillo et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Long-Term Reduction in Peripheral Blood HIV Type 1 Reservoirs Following Reduced-Intensity Conditioning Allogeneic Stem Cell Transplantation

(2013) T. J. Henrich et al.   JOURNAL OF INFECTIOUS DISEASES

CD133+ Hematopoietic Progenitor Cells Harbor HIV Genomes in a Subset of Optimally Treated People With Long-Term Viral Suppression

(2013) L. A. McNamara et al.   JOURNAL OF INFECTIOUS DISEASES

High Levels of CD2 Expression Identify HIV-1 Latently Infected Resting Memory CD4+ T Cells in Virally Suppressed Subjects

(2013) M. Iglesias-Ussel et al.   JOURNAL OF VIROLOGY

Epigenetic Regulation of HIV-1 Latency in Astrocytes

(2013) S. D. Narasipura et al.   JOURNAL OF VIROLOGY

Endothelial Cell Stimulation Overcomes Restriction and Promotes Productive and Latent HIV-1 Infection of Resting CD4+ T Cells

(2013) A. Shen et al.   JOURNAL OF VIROLOGY

Immune clearance of highly pathogenic SIV infection

(2013) Scott G. Hansen et al.   NATURE

Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant

(2013) Deborah Persaud et al.   NEW ENGLAND JOURNAL OF MEDICINE

Administration of a Toll-Like Receptor 9 Agonist Decreases the Proviral Reservoir in Virologically Suppressed HIV-Infected Patients

(2013) Anni A. Winckelmann et al.   PLoS One

Gag-Positive Reservoir Cells Are Susceptible to HIV-Specific Cytotoxic T Lymphocyte Mediated Clearance In Vitro and Can Be Detected In Vivo

(2013) Erin H. Graf et al.   PLoS One

Drug-Induced Reactivation of Apoptosis Abrogates HIV-1 Infection

(2013) Hartmut M. Hanauske-Abel et al.   PLoS One

Reactivation of latent HIV by histone deacetylase inhibitors

(2013) Kotaro Shirakawa et al.   TRENDS IN MICROBIOLOGY

Epigenetic analysis of HIV-1 proviral genomes from infected individuals: Predominance of unmethylated CpG's

(2013) Stefanie Weber et al.   VIROLOGY

Stem-Cell-Based Gene Therapy for HIV Infection

(2013) Anjie Zhen et al.   Viruses-Basel

Altering cell death pathways as an approach to cure HIV infection

(2013) A D Badley et al.   Cell Death & Disease

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

(2013) Hirotaka Ebina et al.   Scientific Reports

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

Therapeutics for HIV-1 reactivation from latency

(2013) Marco Sgarbanti et al.   Current Opinion in Virology

Establishment and molecular mechanisms of HIV-1 latency in T cells

(2013) Renée M van der Sluis et al.   Current Opinion in Virology

Eliminating the latent HIV reservoir by reactivation strategies: Advancing to clinical trials

(2013) Thomas Rasmussen et al.   Human Vaccines & Immunotherapeutics

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

(2013) Celsa A. Spina et al.   PLoS Pathogens

Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study

(2013) Asier Sáez-Cirión et al.   PLoS Pathogens

The effect of intensification with raltegravir on the HIV-1 reservoir of latently infected memory CD4 T cells in suppressed patients

(2012) Alejandro Vallejo et al.   AIDS

Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog

(2012) Geneviève Doyon et al.   AIDS

The development of immune-modulating compounds to disrupt HIV latency

(2012) Anna Lisa Remoli et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Targeting HIV latency: pharmacologic strategies toward eradication

(2012) Sifei Xing et al.   DRUG DISCOVERY TODAY

Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study

(2012) JP Routy et al.   HIV MEDICINE

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

(2012) Liang Shan et al.   IMMUNITY

Interferon Alfa Therapy: Toward an Improved Treatment for HIV Infection

(2012) L. A. McNamara et al.   JOURNAL OF INFECTIOUS DISEASES

Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration

(2012) Livio Azzoni et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 DNA Is Detected in Bone Marrow Populations Containing CD4+ T Cells but Is not Found in Purified CD34+ Hematopoietic Progenitor Cells in Most Patients on Antiretroviral Therapy

(2012) Christine M. Durand et al.   JOURNAL OF INFECTIOUS DISEASES

Hematopoietic Precursor Cells Isolated From Patients on Long-term Suppressive HIV Therapy Did Not Contain HIV-1 DNA

(2012) Lina Josefsson et al.   JOURNAL OF INFECTIOUS DISEASES

Latent HIV-1 Infection Occurs in Multiple Subsets of Hematopoietic Progenitor Cells and Is Reversed by NF- B Activation

(2012) L. A. McNamara et al.   JOURNAL OF VIROLOGY

Generation of an HIV-1-Resistant Immune System with CD34+ Hematopoietic Stem Cells Transduced with a Triple-Combination Anti-HIV Lentiviral Vector

(2012) J. E. Walker et al.   JOURNAL OF VIROLOGY

Immune Selection In Vitro Reveals Human Immunodeficiency Virus Type 1 Nef Sequence Motifs Important for Its Immune Evasion Function In Vivo

(2012) M. J. Lewis et al.   JOURNAL OF VIROLOGY

Paucity of HIV DNA Methylation in Latently Infected, Resting CD4+ T Cells from Infected Individuals Receiving Antiretroviral Therapy

(2012) J. Blazkova et al.   JOURNAL OF VIROLOGY

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Pre-Clinical Evaluation of a 213Bi-Labeled 2556 Antibody to HIV-1 gp41 Glycoprotein in HIV-1 Mouse Models as a Reagent for HIV Eradication

(2012) Ekaterina Dadachova et al.   PLoS One

Macrophages and their relevance in Human Immunodeficiency Virus Type I infection

(2012) Herwig Koppensteiner et al.   Retrovirology

Direct Toll-Like Receptor-Mediated Stimulation of Hematopoietic Stem and Progenitor Cells Occurs In Vivo and Promotes Differentiation Toward Macrophages

(2012) Javier Megías et al.   STEM CELLS

Directly Infected Resting CD4+T Cells Can Produce HIV Gag without Spreading Infection in a Model of HIV Latency

(2012) Matthew J. Pace et al.   PLoS Pathogens

In Vivo Suppression of HIV by Antigen Specific T Cells Derived from Engineered Hematopoietic Stem Cells

(2012) Scott G. Kitchen et al.   PLoS Pathogens

Attacking the HIV Reservoir from the Immune and Viral Perspective

(2012) Marta Massanella et al.   Current HIV/AIDS Reports

HIV-1 Utilizes the CXCR4 Chemokine Receptor to Infect Multipotent Hematopoietic Stem and Progenitor Cells

(2011) Christoph C. Carter et al.   Cell Host & Microbe

Hematopoiesis sculpted by pathogens: Toll-like receptors and inflammatory mediators directly activate stem cells

(2011) Julie R. Boiko et al.   CYTOKINE

TLR8 Activates HIV from Latently Infected Cells of Myeloid-Monocytic Origin Directly via the MAPK Pathway and from Latently Infected CD4 + T Cells Indirectly via TNF-α

(2011) Erika Schlaepfer et al.   JOURNAL OF IMMUNOLOGY

Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells

(2011) B. L. Esplin et al.   JOURNAL OF IMMUNOLOGY

Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation

(2011) S. Xing et al.   JOURNAL OF VIROLOGY

Clonal Sequences Recovered from Plasma from Patients with Residual HIV-1 Viremia and on Intensified Antiretroviral Therapy Are Identical to Replicating Viral RNAs Recovered from Circulating Resting CD4+ T Cells

(2011) J. A. Anderson et al.   JOURNAL OF VIROLOGY

Latent HIV-1 Infection of Resting CD4+ T Cells in the Humanized Rag2-/-  c-/- Mouse

(2011) S. K. Choudhary et al.   JOURNAL OF VIROLOGY

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE

Inflammatory signals regulate hematopoietic stem cells

(2011) Megan T. Baldridge et al.   TRENDS IN IMMUNOLOGY

HIV reservoirs and latency models

(2011) Matthew J. Pace et al.   VIROLOGY

Deep Molecular Characterization of HIV-1 Dynamics under Suppressive HAART

(2011) Maria J. Buzón et al.   PLoS Pathogens

Homeostatic Proliferation Fails to Efficiently Reactivate HIV-1 Latently Infected Central Memory CD4+ T Cells

(2011) Alberto Bosque et al.   PLoS Pathogens

Episomal Viral cDNAs Identify a Reservoir That Fuels Viral Rebound after Treatment Interruption and That Contributes to Treatment Failure

(2011) Mark Sharkey et al.   PLoS Pathogens

Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy

(2010) Steven A Yukl et al.   AIDS

Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation

(2010) K. Allers et al.   BLOOD

Manipulation of Host Cell Death Pathways during Microbial Infections

(2010) Mohamed Lamkanfi et al.   Cell Host & Microbe

Simian Immunodeficiency Virus–Infected Macaques Treated with Highly Active Antiretroviral Therapy Have Reduced Central Nervous System Viral Replication and Inflammation but Persistence of Viral DNA

(2010) M. Christine Zink et al.   JOURNAL OF INFECTIOUS DISEASES

Establishment of HIV Latency in Primary CD4+ Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction

(2010) M. Tyagi et al.   JOURNAL OF VIROLOGY

Studies of HIV-1 latency in an ex vivo model that uses primary central memory T cells

(2010) Alberto Bosque et al.   METHODS

HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs

(2010) Christoph C Carter et al.   NATURE MEDICINE

HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects

(2010) Maria J Buzón et al.   NATURE MEDICINE

Antiretroviral Intensification and Valproic Acid Lack Sustained Effect on Residual HIV-1 Viremia or Resting CD4+ Cell Infection

(2010) Nancie M. Archin et al.   PLoS One

Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage

(2010) Valentin Le Douce et al.   Retrovirology

HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals

(2010) D. Trono et al.   SCIENCE

Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir

(2009) Nathalie Sagot-Lerolle et al.   AIDS

Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid

(2009) Nancie M. Archin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

(2009) Melissa J. Churchill et al.   ANNALS OF NEUROLOGY

Suberoylanilide Hydroxamic Acid Reactivates HIV from Latently Infected Cells

(2009) Xavier Contreras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Viral Sanctuaries during Highly Active Antiretroviral Therapy in a Nonhuman Primate Model for AIDS

(2009) T. W. North et al.   JOURNAL OF VIROLOGY

Analysis of Human Immunodeficiency Virus Type 1 Viremia and Provirus in Resting CD4+ T Cells Reveals a Novel Source of Residual Viremia in Patients on Antiretroviral Therapy

(2009) T. P. Brennan et al.   JOURNAL OF VIROLOGY

Defective Human Immunodeficiency Virus-Specific CD8+ T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral Therapy

(2009) S. A. Migueles et al.   JOURNAL OF VIROLOGY

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

TLR5 stimulation is sufficient to trigger reactivation of latent HIV-1 provirus in T lymphoid cells and activate virus gene expression in central memory CD4+ T cells

(2009) Sandra Thibault et al.   VIROLOGY

CpG Methylation Controls Reactivation of HIV from Latency

(2009) Jana Blazkova et al.   PLoS Pathogens

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

(2009) Steven E. Kauder et al.   PLoS Pathogens

Hexamethylbisacetamide and Disruption of Human Immunodeficiency Virus Type 1 Latency in CD4+T Cells

(2008) Shailesh K. Choudhary et al.   JOURNAL OF INFECTIOUS DISEASES

Low-level plasma HIVs in patients on prolonged suppressive highly active antiretroviral therapy are produced mostly by cells other than CD4 T-cells

(2008) Gautam K. Sahu et al.   JOURNAL OF MEDICAL VIROLOGY

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

(2008) S. Palmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA