Targeting HIV latency: resting memory T cells, hematopoietic progenitor cells and future directions
出版年份 2014 全文链接
标题
Targeting HIV latency: resting memory T cells, hematopoietic progenitor cells and future directions
作者
关键词
-
出版物
Expert Review of Anti-Infective Therapy
Volume 12, Issue 10, Pages 1187-1201
出版商
Informa UK Limited
发表日期
2014-09-05
DOI
10.1586/14787210.2014.956094
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Functional Adaptation of Nef to the Immune Milieu of HIV-1 Infection In Vivo
- (2014) M. J. Lewis et al. JOURNAL OF IMMUNOLOGY
- HIV DNA Subspecies Persist in both Activated and Resting Memory CD4+ T Cells during Antiretroviral Therapy
- (2014) J. M. Murray et al. JOURNAL OF VIROLOGY
- CD4+ Memory Stem Cells Are Infected by HIV-1 in a Manner Regulated in Part by SAMHD1 Expression
- (2014) C. O. Tabler et al. JOURNAL OF VIROLOGY
- Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial
- (2014) Beatriz Grinsztejn et al. LANCET INFECTIOUS DISEASES
- HIV-1 persistence in CD4+ T cells with stem cell–like properties
- (2014) Maria J Buzon et al. NATURE MEDICINE
- New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo
- (2014) C Korin Bullen et al. NATURE MEDICINE
- Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV
- (2014) Pablo Tebas et al. NEW ENGLAND JOURNAL OF MEDICINE
- Residual Viremia in an RT-SHIV Rhesus Macaque HAART Model Marked by the Presence of a Predominant Plasma Clone and a Lack of Viral Evolution
- (2014) Robert C. Kauffman et al. PLoS One
- Expansion of HAART Coverage Is Associated with Sustained Decreases in HIV/AIDS Morbidity, Mortality and HIV Transmission: The “HIV Treatment as Prevention” Experience in a Canadian Setting
- (2014) Julio S.G. Montaner et al. PLoS One
- Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy
- (2014) A. R. Cillo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Immunologic strategies for HIV-1 remission and eradication
- (2014) D. H. Barouch et al. SCIENCE
- HIV-1 Latency in Monocytes/Macrophages
- (2014) Amit Kumar et al. Viruses-Basel
- Quantifying Susceptibility of CD4+ Stem Memory T-Cells to Infection by Laboratory Adapted and Clinical HIV-1 Strains
- (2014) Jacqueline Flynn et al. Viruses-Basel
- Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART
- (2014) Paul W. Denton et al. PLoS Pathogens
- Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing
- (2014) Datsen George Wei et al. PLoS Pathogens
- Thirty Years of HIV and AIDS: Future Challenges and Opportunities
- (2013) Carl W. Dieffenbach et al. ANNALS OF INTERNAL MEDICINE
- HIV-1 infection of hematopoietic progenitor cells in vivo in humanized mice
- (2013) C. C. Nixon et al. BLOOD
- Interleukin-7 promotes HIV persistence during antiretroviral therapy
- (2013) C. Vandergeeten et al. BLOOD
- Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure
- (2013) Ya-Chi Ho et al. CELL
- Restrictions to HIV-1 replication in resting CD4+ T lymphocytes
- (2013) Xiaoyu Pan et al. CELL RESEARCH
- A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1-Infected Adults on Antiretroviral Therapy
- (2013) A. M. Spivak et al. CLINICAL INFECTIOUS DISEASES
- Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce
- (2013) Alberto Yáñez et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Immune interventions in HIV infection
- (2013) Guislaine Carcelain et al. IMMUNOLOGICAL REVIEWS
- Dynamics of CD8 T-Cell Activation After Discontinuation of HIV Treatment Intensification
- (2013) Marta Massanella et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Plasma Viremia and Cellular HIV-1 DNA Persist Despite Autologous Hematopoietic Stem Cell Transplantation for HIV-Related Lymphoma
- (2013) Anthony R. Cillo et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Long-Term Reduction in Peripheral Blood HIV Type 1 Reservoirs Following Reduced-Intensity Conditioning Allogeneic Stem Cell Transplantation
- (2013) T. J. Henrich et al. JOURNAL OF INFECTIOUS DISEASES
- CD133+ Hematopoietic Progenitor Cells Harbor HIV Genomes in a Subset of Optimally Treated People With Long-Term Viral Suppression
- (2013) L. A. McNamara et al. JOURNAL OF INFECTIOUS DISEASES
- High Levels of CD2 Expression Identify HIV-1 Latently Infected Resting Memory CD4+ T Cells in Virally Suppressed Subjects
- (2013) M. Iglesias-Ussel et al. JOURNAL OF VIROLOGY
- Epigenetic Regulation of HIV-1 Latency in Astrocytes
- (2013) S. D. Narasipura et al. JOURNAL OF VIROLOGY
- Endothelial Cell Stimulation Overcomes Restriction and Promotes Productive and Latent HIV-1 Infection of Resting CD4+ T Cells
- (2013) A. Shen et al. JOURNAL OF VIROLOGY
- Immune clearance of highly pathogenic SIV infection
- (2013) Scott G. Hansen et al. NATURE
- Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant
- (2013) Deborah Persaud et al. NEW ENGLAND JOURNAL OF MEDICINE
- Administration of a Toll-Like Receptor 9 Agonist Decreases the Proviral Reservoir in Virologically Suppressed HIV-Infected Patients
- (2013) Anni A. Winckelmann et al. PLoS One
- Gag-Positive Reservoir Cells Are Susceptible to HIV-Specific Cytotoxic T Lymphocyte Mediated Clearance In Vitro and Can Be Detected In Vivo
- (2013) Erin H. Graf et al. PLoS One
- Drug-Induced Reactivation of Apoptosis Abrogates HIV-1 Infection
- (2013) Hartmut M. Hanauske-Abel et al. PLoS One
- Reactivation of latent HIV by histone deacetylase inhibitors
- (2013) Kotaro Shirakawa et al. TRENDS IN MICROBIOLOGY
- Epigenetic analysis of HIV-1 proviral genomes from infected individuals: Predominance of unmethylated CpG's
- (2013) Stefanie Weber et al. VIROLOGY
- Stem-Cell-Based Gene Therapy for HIV Infection
- (2013) Anjie Zhen et al. Viruses-Basel
- Altering cell death pathways as an approach to cure HIV infection
- (2013) A D Badley et al. Cell Death & Disease
- Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus
- (2013) Hirotaka Ebina et al. Scientific Reports
- HIV Latency
- (2013) R. F. Siliciano et al. Cold Spring Harbor Perspectives in Medicine
- Therapeutics for HIV-1 reactivation from latency
- (2013) Marco Sgarbanti et al. Current Opinion in Virology
- Establishment and molecular mechanisms of HIV-1 latency in T cells
- (2013) Renée M van der Sluis et al. Current Opinion in Virology
- Eliminating the latent HIV reservoir by reactivation strategies: Advancing to clinical trials
- (2013) Thomas Rasmussen et al. Human Vaccines & Immunotherapeutics
- An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients
- (2013) Celsa A. Spina et al. PLoS Pathogens
- Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study
- (2013) Asier Sáez-Cirión et al. PLoS Pathogens
- The effect of intensification with raltegravir on the HIV-1 reservoir of latently infected memory CD4 T cells in suppressed patients
- (2012) Alejandro Vallejo et al. AIDS
- Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog
- (2012) Geneviève Doyon et al. AIDS
- The development of immune-modulating compounds to disrupt HIV latency
- (2012) Anna Lisa Remoli et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Targeting HIV latency: pharmacologic strategies toward eradication
- (2012) Sifei Xing et al. DRUG DISCOVERY TODAY
- Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study
- (2012) JP Routy et al. HIV MEDICINE
- Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation
- (2012) Liang Shan et al. IMMUNITY
- Interferon Alfa Therapy: Toward an Improved Treatment for HIV Infection
- (2012) L. A. McNamara et al. JOURNAL OF INFECTIOUS DISEASES
- Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration
- (2012) Livio Azzoni et al. JOURNAL OF INFECTIOUS DISEASES
- HIV-1 DNA Is Detected in Bone Marrow Populations Containing CD4+ T Cells but Is not Found in Purified CD34+ Hematopoietic Progenitor Cells in Most Patients on Antiretroviral Therapy
- (2012) Christine M. Durand et al. JOURNAL OF INFECTIOUS DISEASES
- Hematopoietic Precursor Cells Isolated From Patients on Long-term Suppressive HIV Therapy Did Not Contain HIV-1 DNA
- (2012) Lina Josefsson et al. JOURNAL OF INFECTIOUS DISEASES
- Latent HIV-1 Infection Occurs in Multiple Subsets of Hematopoietic Progenitor Cells and Is Reversed by NF- B Activation
- (2012) L. A. McNamara et al. JOURNAL OF VIROLOGY
- Generation of an HIV-1-Resistant Immune System with CD34+ Hematopoietic Stem Cells Transduced with a Triple-Combination Anti-HIV Lentiviral Vector
- (2012) J. E. Walker et al. JOURNAL OF VIROLOGY
- Immune Selection In Vitro Reveals Human Immunodeficiency Virus Type 1 Nef Sequence Motifs Important for Its Immune Evasion Function In Vivo
- (2012) M. J. Lewis et al. JOURNAL OF VIROLOGY
- Paucity of HIV DNA Methylation in Latently Infected, Resting CD4+ T Cells from Infected Individuals Receiving Antiretroviral Therapy
- (2012) J. Blazkova et al. JOURNAL OF VIROLOGY
- Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
- (2012) N. M. Archin et al. NATURE
- Pre-Clinical Evaluation of a 213Bi-Labeled 2556 Antibody to HIV-1 gp41 Glycoprotein in HIV-1 Mouse Models as a Reagent for HIV Eradication
- (2012) Ekaterina Dadachova et al. PLoS One
- Macrophages and their relevance in Human Immunodeficiency Virus Type I infection
- (2012) Herwig Koppensteiner et al. Retrovirology
- Direct Toll-Like Receptor-Mediated Stimulation of Hematopoietic Stem and Progenitor Cells Occurs In Vivo and Promotes Differentiation Toward Macrophages
- (2012) Javier Megías et al. STEM CELLS
- Directly Infected Resting CD4+T Cells Can Produce HIV Gag without Spreading Infection in a Model of HIV Latency
- (2012) Matthew J. Pace et al. PLoS Pathogens
- In Vivo Suppression of HIV by Antigen Specific T Cells Derived from Engineered Hematopoietic Stem Cells
- (2012) Scott G. Kitchen et al. PLoS Pathogens
- Attacking the HIV Reservoir from the Immune and Viral Perspective
- (2012) Marta Massanella et al. Current HIV/AIDS Reports
- HIV-1 Utilizes the CXCR4 Chemokine Receptor to Infect Multipotent Hematopoietic Stem and Progenitor Cells
- (2011) Christoph C. Carter et al. Cell Host & Microbe
- Hematopoiesis sculpted by pathogens: Toll-like receptors and inflammatory mediators directly activate stem cells
- (2011) Julie R. Boiko et al. CYTOKINE
- TLR8 Activates HIV from Latently Infected Cells of Myeloid-Monocytic Origin Directly via the MAPK Pathway and from Latently Infected CD4 + T Cells Indirectly via TNF-α
- (2011) Erika Schlaepfer et al. JOURNAL OF IMMUNOLOGY
- Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells
- (2011) B. L. Esplin et al. JOURNAL OF IMMUNOLOGY
- Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation
- (2011) S. Xing et al. JOURNAL OF VIROLOGY
- Clonal Sequences Recovered from Plasma from Patients with Residual HIV-1 Viremia and on Intensified Antiretroviral Therapy Are Identical to Replicating Viral RNAs Recovered from Circulating Resting CD4+ T Cells
- (2011) J. A. Anderson et al. JOURNAL OF VIROLOGY
- Latent HIV-1 Infection of Resting CD4+ T Cells in the Humanized Rag2-/- c-/- Mouse
- (2011) S. K. Choudhary et al. JOURNAL OF VIROLOGY
- A human memory T cell subset with stem cell–like properties
- (2011) Luca Gattinoni et al. NATURE MEDICINE
- Inflammatory signals regulate hematopoietic stem cells
- (2011) Megan T. Baldridge et al. TRENDS IN IMMUNOLOGY
- HIV reservoirs and latency models
- (2011) Matthew J. Pace et al. VIROLOGY
- Deep Molecular Characterization of HIV-1 Dynamics under Suppressive HAART
- (2011) Maria J. Buzón et al. PLoS Pathogens
- Homeostatic Proliferation Fails to Efficiently Reactivate HIV-1 Latently Infected Central Memory CD4+ T Cells
- (2011) Alberto Bosque et al. PLoS Pathogens
- Episomal Viral cDNAs Identify a Reservoir That Fuels Viral Rebound after Treatment Interruption and That Contributes to Treatment Failure
- (2011) Mark Sharkey et al. PLoS Pathogens
- Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy
- (2010) Steven A Yukl et al. AIDS
- Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation
- (2010) K. Allers et al. BLOOD
- Manipulation of Host Cell Death Pathways during Microbial Infections
- (2010) Mohamed Lamkanfi et al. Cell Host & Microbe
- Simian Immunodeficiency Virus–Infected Macaques Treated with Highly Active Antiretroviral Therapy Have Reduced Central Nervous System Viral Replication and Inflammation but Persistence of Viral DNA
- (2010) M. Christine Zink et al. JOURNAL OF INFECTIOUS DISEASES
- Establishment of HIV Latency in Primary CD4+ Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction
- (2010) M. Tyagi et al. JOURNAL OF VIROLOGY
- Studies of HIV-1 latency in an ex vivo model that uses primary central memory T cells
- (2010) Alberto Bosque et al. METHODS
- HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs
- (2010) Christoph C Carter et al. NATURE MEDICINE
- HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects
- (2010) Maria J Buzón et al. NATURE MEDICINE
- Antiretroviral Intensification and Valproic Acid Lack Sustained Effect on Residual HIV-1 Viremia or Resting CD4+ Cell Infection
- (2010) Nancie M. Archin et al. PLoS One
- Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage
- (2010) Valentin Le Douce et al. Retrovirology
- HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals
- (2010) D. Trono et al. SCIENCE
- Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir
- (2009) Nathalie Sagot-Lerolle et al. AIDS
- Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid
- (2009) Nancie M. Archin et al. AIDS RESEARCH AND HUMAN RETROVIRUSES
- Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia
- (2009) Melissa J. Churchill et al. ANNALS OF NEUROLOGY
- Suberoylanilide Hydroxamic Acid Reactivates HIV from Latently Infected Cells
- (2009) Xavier Contreras et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Viral Sanctuaries during Highly Active Antiretroviral Therapy in a Nonhuman Primate Model for AIDS
- (2009) T. W. North et al. JOURNAL OF VIROLOGY
- Analysis of Human Immunodeficiency Virus Type 1 Viremia and Provirus in Resting CD4+ T Cells Reveals a Novel Source of Residual Viremia in Patients on Antiretroviral Therapy
- (2009) T. P. Brennan et al. JOURNAL OF VIROLOGY
- Defective Human Immunodeficiency Virus-Specific CD8+ T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral Therapy
- (2009) S. A. Migueles et al. JOURNAL OF VIROLOGY
- HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
- (2009) Nicolas Chomont et al. NATURE MEDICINE
- Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation
- (2009) Gero Hütter et al. NEW ENGLAND JOURNAL OF MEDICINE
- TLR5 stimulation is sufficient to trigger reactivation of latent HIV-1 provirus in T lymphoid cells and activate virus gene expression in central memory CD4+ T cells
- (2009) Sandra Thibault et al. VIROLOGY
- CpG Methylation Controls Reactivation of HIV from Latency
- (2009) Jana Blazkova et al. PLoS Pathogens
- Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation
- (2009) Steven E. Kauder et al. PLoS Pathogens
- Hexamethylbisacetamide and Disruption of Human Immunodeficiency Virus Type 1 Latency in CD4+T Cells
- (2008) Shailesh K. Choudhary et al. JOURNAL OF INFECTIOUS DISEASES
- Low-level plasma HIVs in patients on prolonged suppressive highly active antiretroviral therapy are produced mostly by cells other than CD4 T-cells
- (2008) Gautam K. Sahu et al. JOURNAL OF MEDICAL VIROLOGY
- Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy
- (2008) S. Palmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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