New targets in the search for preventive and therapeutic agents for botulism

Current strategies for designing antidotes against botulinum neurotoxins

(2014) Kruti Patel et al.   Expert Opinion on Drug Discovery

Botulinum Neurotoxin Vaccines:  Past history and recent developments

(2014) Janice M. Rusnak et al.   Human vaccines & immunotherapeutics

Identification of Clinically Viable Quinolinol Inhibitors of Botulinum Neurotoxin A Light Chain

(2014) Dejan Caglič et al.   JOURNAL OF MEDICINAL CHEMISTRY

Botulinum neurotoxins: genetic, structural and mechanistic insights

(2014) Ornella Rossetto et al.   NATURE REVIEWS MICROBIOLOGY

Evaluating the Synergistic Neutralizing Effect of Anti-Botulinum Oligoclonal Antibody Preparations

(2014) Eran Diamant et al.   PLoS One

Transcriptomic Analysis of (Group I) Clostridium botulinum ATCC 3502 Cold Shock Response

(2014) Elias Dahlsten et al.   PLoS One

Probiotics and prebiotics in pediatric diarrheal disorders

(2013) Y Vandenplas et al.   EXPERT OPINION ON PHARMACOTHERAPY

Enhancing the Protective Immune Response against Botulism

(2013) Amanda Przedpelski et al.   INFECTION AND IMMUNITY

Molecular Characterization of a Novel Botulinum Neurotoxin Type H Gene

(2013) Nir Dover et al.   JOURNAL OF INFECTIOUS DISEASES

A Novel Strain of Clostridium botulinum That Produces Type B and Type H Botulinum Toxins

(2013) Jason R. Barash et al.   JOURNAL OF INFECTIOUS DISEASES

Mechanisms of enhanced neutralization of botulinum neurotoxin by monoclonal antibodies conjugated to antibodies specific for the erythrocyte complement receptor

(2013) Rashmi Sharma et al.   MOLECULAR IMMUNOLOGY

Regulation of toxin synthesis in Clostridium botulinum and Clostridium tetani

(2013) Chloé Connan et al.   TOXICON

Evidence-based review and assessment of botulinum neurotoxin for the treatment of movement disorders

(2013) Mark Hallett et al.   TOXICON

Botulinum neurotoxins

(2013) O. Rossetto et al.   TOXICON

The life history of a botulinum toxin molecule

(2013) Lance Simpson   TOXICON

Potent tetravalent replicon vaccines against botulinum neurotoxins using DNA-based Semliki Forest virus replicon vectors

(2013) Yun-Zhou Yu et al.   VACCINE

Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure–activity relationship and pharmacophore modeling

(2012) Gyanendra Kumar et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies

(2012) Peter Šilhár et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Vaccines against botulism

(2012) Andrew P-A Karalewitz et al.   CURRENT OPINION IN MICROBIOLOGY

The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals

(2012) Marco Pirazzini et al.   FEBS LETTERS

Reversal of BoNT/A-mediated inhibition of muscle paralysis by 3,4-diaminopyridine and roscovitine in mouse phrenic nerve-hemidiaphragm preparations

(2012) Michael Adler et al.   NEUROCHEMISTRY INTERNATIONAL

RNAi suppression of rice endogenous storage proteins enhances the production of rice-based Botulinum neutrotoxin type A vaccine

(2012) Yoshikazu Yuki et al.   VACCINE

Antagonistic effect of different bacteria onClostridium botulinumtypes A, B, D and E in vitro: TABLE 1:

(2012) A. Shehata et al.   VETERINARY RECORD

Botulinum toxin: Therapeutic agent to cosmetic enhancement to lethal biothreat

(2011) Peter Katona   ANAEROBE

Structural Characterization of Three Novel Hydroxamate-Based Zinc Chelating Inhibitors of theClostridium botulinumSerotype A Neurotoxin Light Chain Metalloprotease Reveals a Compact Binding Site Resulting from 60/70 Loop Flexibility

(2011) Aaron A. Thompson et al.   BIOCHEMISTRY

Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization

(2011) Joseph S. Zakhari et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors

(2011) Bing Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease

(2011) Peter Šilhár et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action

(2011) Nicholas T. Salzameda et al.   CHEMICAL COMMUNICATIONS

Equine Botulinum Antitoxin for the Treatment of Infant Botulism

(2011) Elida E. Vanella de Cuetos et al.   Clinical and Vaccine Immunology

Molecular structures and functional relationships in clostridial neurotoxins

(2011) Subramanyam Swaminathan   FEBS Journal

Enhancement of the immunogenicity of DNA replicon vaccine ofClostridium botulinumneurotoxin serotype A byGM-CSFgene adjuvant

(2011) Na Li et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Rapid Immune Responses to a Botulinum Neurotoxin Hc Subunit Vaccine throughIn VivoTargeting to Antigen-Presenting Cells

(2011) David M. White et al.   INFECTION AND IMMUNITY

Botulinum Neurotoxins and Botulism: A Novel Therapeutic Approach

(2011) Jeeraphong Thanongsaksrikul et al.   Toxins

Symptomatic Relief of Botulinum Neurotoxin/A Intoxication with Aminopyridines: A New Twist on an Old Molecule

(2010) Alexander V. Mayorov et al.   ACS Chemical Biology

Efficacy of a Potential Trivalent Vaccine Based on Hc Fragments of Botulinum Toxins A, B, and E Produced in a Cell-Free Expression System

(2010) R. Zichel et al.   Clinical and Vaccine Immunology

Botulism, where are we now?

(2010) Jiu-Cong Zhang et al.   CLINICAL TOXICOLOGY

Lag time variability in individual spores of Clostridium botulinum

(2010) S.C. Stringer et al.   FOOD MICROBIOLOGY

Clostridium botulinum in the post-genomic era

(2010) Michael W. Peck et al.   FOOD MICROBIOLOGY

Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication

(2010) Bing Li et al.   MOLECULES

Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases

(2010) Jacqueline M. Tremblay et al.   TOXICON

Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease

(2010) Lisa M. Eubanks et al.   ACS Medicinal Chemistry Letters

Contrasting Effects of Heat Treatment and Incubation Temperature on Germination and Outgrowth of Individual Spores of Nonproteolytic Clostridium botulinum Bacteria

(2009) S. C. Stringer et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Toosendanin: Synthesis of the AB-ring and investigations of its anti-botulinum properties (Part II)

(2009) Yuya Nakai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Wound Botulism Complicating Internal Fixation of a Complex Radial Fracture

(2009) S. M. Taylor et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins

(2009) Kateřina Čapková et al.   TOXICON

Botulism and vaccines for its prevention

(2009) Leonard A. Smith   VACCINE

Cell-penetrating peptides: from molecular mechanisms to therapeutics

(2008) May C. Morris et al.   BIOLOGY OF THE CELL

Function-oriented synthesis applied to the anti-botulinum natural product toosendanin

(2008) Yuya Nakai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

An improved method for development of toxoid vaccines and antitoxins

(2008) Russell G.A. Jones et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Assessment of the potential for growth and neurotoxin formation by non-proteolytic Clostridium botulinum in short shelf-life commercial foods designed to be stored chilled☆

(2007) M PECK et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY