Molecular structures and functional relationships in clostridial neurotoxins

Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner

(2010) Jasmin Strotmeier et al.   BIOCHEMICAL JOURNAL

Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA,

(2010) Andrew P.-A. Karalewitz et al.   BIOCHEMISTRY

Basic Tetrapeptides as Potent Intracellular Inhibitors of Type A Botulinum Neurotoxin Protease Activity

(2010) Martha Hale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Botulinum Neurotoxin Type G Binding Domain: Insight into Cell Surface Binding

(2010) Pål Stenmark et al.   JOURNAL OF MOLECULAR BIOLOGY

Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A

(2010) Jorge E. Zuniga et al.   PLoS One

SV2 Mediates Entry of Tetanus Neurotoxin into Central Neurons

(2010) Felix L. Yeh et al.   PLoS Pathogens

Identification and Biochemical Characterization of Small-Molecule Inhibitors of Clostridium botulinum Neurotoxin Serotype A

(2009) V. Roxas-Duncan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quinolinol and peptide inhibitors of zinc protease in botulinum neurotoxin A: Effects of zinc ion and peptides on inhibition

(2009) Huiguo Lai et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Crystal structure of a catalytically active, non-toxic endopeptidase derivative of Clostridium botulinum toxin A

(2009) Geoffrey Masuyer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The N-terminal half of the receptor domain of botulinum neurotoxin A binds to microdomains of the plasma membrane

(2009) Lucia Muraro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F

(2009) Zhuji Fu et al.   BIOCHEMISTRY

Cell entry strategy of clostridial neurotoxins

(2009) Thomas Binz et al.   JOURNAL OF NEUROCHEMISTRY

Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F

(2009) Rakhi Agarwal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Potent New Small-Molecule Inhibitor of Botulinum Neurotoxin Serotype A Endopeptidase Developed by Synthesis-Based Computer-Aided Molecular Design

(2009) Yuan-Ping Pang et al.   PLoS One

Bimodal modulation of the botulinum neurotoxin protein-conducting channel

(2009) A. Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering botulinum neurotoxin to extend therapeutic intervention

(2009) S. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins

(2009) Kateřina Čapková et al.   TOXICON

Engineered toxins: New therapeutics

(2009) Keith A. Foster   TOXICON

Catalytic Features of the Botulinum Neurotoxin A Light Chain Revealed by High Resolution Structure of an Inhibitory Peptide Complex†‡

(2008) Nicholas R. Silvaggi et al.   BIOCHEMISTRY

SNAP-25 Substrate Peptide (Residues 180–183) Binds to but Bypasses Cleavage by Catalytically ActiveClostridium botulinumNeurotoxin E

(2008) Rakhi Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure- and Substrate-based Inhibitor Design forClostridium botulinumNeurotoxin Serotype A

(2008) Desigan Kumaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate Recognition Mechanism of VAMP/Synaptobrevin-cleaving Clostridial Neurotoxins

(2008) Stefan Sikorra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Chimeras of Botulinum Neurotoxins A and E Unveil Contributions from the Binding, Translocation, and Protease Domains to Their Functional Characteristics

(2008) Jiafu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Interaction of Botulinum Neurotoxin A Translocation (T) Domain

(2008) Marie Galloux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Domain Organization in Clostridium botulinum Neurotoxin Type E Is Unique: Its Implication in Faster Translocation

(2008) Desigan Kumaran et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of the receptor-binding sites in the carboxyl-terminal half of the heavy chain of botulinum neurotoxin types C and D

(2008) Kentaro Tsukamoto et al.   MICROBIAL PATHOGENESIS

Glycosylated SV2A and SV2B Mediate the Entry of Botulinum Neurotoxin E into Neurons

(2008) Min Dong et al.   MOLECULAR BIOLOGY OF THE CELL

A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate

(2008) Jorge E. Zuniga et al.   STRUCTURE

Translocation of botulinum neurotoxin light chain protease by the heavy chain protein-conducting channel

(2008) Mauricio Montal   TOXICON

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

(2008) Pål Stenmark et al.   PLoS Pathogens

Substrate Binding Mode and Its Implication on Drug Design for Botulinum Neurotoxin A

(2008) Desigan Kumaran et al.   PLoS Pathogens

Botulinum Neurotoxin Devoid of Receptor Binding Domain Translocates Active Protease

(2008) Audrey Fischer et al.   PLoS Pathogens