Current strategies for designing antidotes against botulinum neurotoxins

The C Terminus of the Catalytic Domain of Type A Botulinum Neurotoxin May Facilitate Product Release from the Active Site

(2013) Rahman M. Mizanur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular assembly of botulinum neurotoxin progenitor complexes

(2013) D. A. Benefield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence-based review and assessment of botulinum neurotoxin for the treatment of movement disorders

(2013) Mark Hallett et al.   TOXICON

Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity

(2013) Kwangkook Lee et al.   PLoS Pathogens

Identification of Fibroblast Growth Factor Receptor 3 (FGFR3) as a Protein Receptor for Botulinum Neurotoxin Serotype A (BoNT/A)

(2013) Birgitte P. S. Jacky et al.   PLoS Pathogens

Structural Framework for Covalent Inhibition ofClostridium botulinumNeurotoxin A by Targeting Cys165

(2012) Enrico A. Stura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversal of BoNT/A-mediated inhibition of muscle paralysis by 3,4-diaminopyridine and roscovitine in mouse phrenic nerve-hemidiaphragm preparations

(2012) Michael Adler et al.   NEUROCHEMISTRY INTERNATIONAL

Small-Molecule Quinolinol Inhibitor Identified Provides Protection against BoNT/A in Mice

(2012) Padma Singh et al.   PLoS One

Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A

(2012) John H. Cardellina et al.   ACS Medicinal Chemistry Letters

Neuronal targeting, internalization, and biological activity of a recombinant atoxic derivative of botulinum neurotoxin A

(2011) Sabine Pellett et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action

(2011) Nicholas T. Salzameda et al.   CHEMICAL COMMUNICATIONS

Molecular aptamers for drug delivery

(2011) Weihong Tan et al.   TRENDS IN BIOTECHNOLOGY

Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors

(2011) Lisheng Peng et al.   PLoS Pathogens

Botulinum Neurotoxins and Botulism: A Novel Therapeutic Approach

(2011) Jeeraphong Thanongsaksrikul et al.   Toxins

Botulinum Neurotoxin: A Marvel of Protein Design

(2010) Mauricio Montal   Annual Review of Biochemistry

In vitro selection of RNA aptamers that inhibit the activity of type A botulinum neurotoxin

(2010) Tzuu-Wang Chang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular Basis of Activation of Endopeptidase Activity of Botulinum Neurotoxin Type E

(2010) Roshan V. Kukreja et al.   BIOCHEMISTRY

Clostridial neurotoxins as a drug delivery vehicle targeting nervous system

(2010) Bal Ram Singh et al.   BIOCHIMIE

Basic Tetrapeptides as Potent Intracellular Inhibitors of Type A Botulinum Neurotoxin Protease Activity

(2010) Martha Hale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Biological Evaluation of Botulinum Neurotoxin A Protease Inhibitors

(2010) Bing Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Botulinum Neurotoxin A Protease: Discovery of Natural Product Exosite Inhibitors

(2010) Peter Šilhár et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A

(2010) Jorge E. Zuniga et al.   PLoS One

Small Molecules Showing Significant Protection of Mice against Botulinum Neurotoxin Serotype A

(2010) Yuan-Ping Pang et al.   PLoS One

Recombinant derivatives of botulinum neurotoxin A engineered for trafficking studies and neuronal delivery

(2010) Philip A. Band et al.   PROTEIN EXPRESSION AND PURIFICATION

Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease

(2010) Lisa M. Eubanks et al.   ACS Medicinal Chemistry Letters

Identification and Biochemical Characterization of Small-Molecule Inhibitors of Clostridium botulinum Neurotoxin Serotype A

(2009) V. Roxas-Duncan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potent New Small-Molecule Inhibitor of Botulinum Neurotoxin Serotype A Endopeptidase Developed by Synthesis-Based Computer-Aided Molecular Design

(2009) Yuan-Ping Pang et al.   PLoS One

Bimodal modulation of the botulinum neurotoxin protein-conducting channel

(2009) A. Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity

(2009) Melissa Pires-Alves et al.   TOXICON

The identification and biochemical characterization of drug-like compounds that inhibit botulinum neurotoxin serotype A endopeptidase activity

(2009) Shuowei Cai et al.   TOXICON

An efficient drug delivery vehicle for botulism countermeasure

(2009) Peng Zhang et al.   BMC Pharmacology & Toxicology

Structure- and Substrate-based Inhibitor Design forClostridium botulinumNeurotoxin Serotype A

(2008) Desigan Kumaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycosylated SV2A and SV2B Mediate the Entry of Botulinum Neurotoxin E into Neurons

(2008) Min Dong et al.   MOLECULAR BIOLOGY OF THE CELL

A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate

(2008) Jorge E. Zuniga et al.   STRUCTURE

Substrate Binding Mode and Its Implication on Drug Design for Botulinum Neurotoxin A

(2008) Desigan Kumaran et al.   PLoS Pathogens