Targeting GSK3 signaling as a potential therapy of neurodegenerative diseases and aging

Aging-associated changes in hippocampal glycogen metabolism in mice. Evidence for and against astrocyte-to-neuron lactate shuttle

(2018) Dominika Drulis-Fajdasz et al.   GLIA

Direct pharmacological Akt activation rescues Alzheimer's disease like memory impairments and aberrant synaptic plasticity

(2018) Jee Hyun Yi et al.   NEUROPHARMACOLOGY

The effect of chronic stimulation of serotonin receptor type 7 on recognition, passive avoidance memory, hippocampal long-term potentiation, and neuronal apoptosis in the amyloid β protein treated rat

(2018) Siamak Shahidi et al.   PSYCHOPHARMACOLOGY

Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study

(2018) Teodoro del Ser et al.   JOURNAL OF ALZHEIMERS DISEASE

Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review

(2017) Błażej Misiak et al.   MOLECULAR NEUROBIOLOGY

Glucocorticoid-mediated activation of GSK3β promotes tau phosphorylation and impairs memory in type 2 diabetes

(2017) Aditi Dey et al.   NEUROBIOLOGY OF AGING

Production of proinflammatory mediators in activated microglia is synergistically regulated by Notch-1, glycogen synthase kinase (GSK-3β) and NF-κB/p65 signalling

(2017) Qiong Cao et al.   PLoS One

Interactions between TGF-β1, canonical WNT/β-catenin pathway and PPAR γ in radiation-induced fibrosis

(2017) Alexandre Vallée et al.   Oncotarget

Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer’s Disease

(2017) Emiliano Peña-Altamira et al.   Frontiers in Aging Neuroscience

GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation

(2017) Agata Gozdz et al.   Frontiers in Molecular Neuroscience

Memantine Inhibits Calpain-Mediated Truncation of GSK-3 Induced by NMDA: Implications in Alzheimer's Disease

(2017) Paloma Goñi-Oliver et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased platelet glycogen sysnthase kinase 3beta in first-episode psychosis

(2017) Helena P.G. Joaquim et al.   SCHIZOPHRENIA RESEARCH

Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity

(2016) Zhao-xiang Ren et al.   ACTA PHARMACOLOGICA SINICA

Early effects of Aβ 1-42 oligomers injection in mice: Involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways

(2016) Fabiana Morroni et al.   BEHAVIOURAL BRAIN RESEARCH

Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease

(2016) Mudasir Maqbool et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fuzhisan ameliorates Aβ production and tau phosphorylation in hippocampal of 11 month old APP/PS1 transgenic mice: A Western blot study

(2016) Zhao-Xu Zhang et al.   EXPERIMENTAL GERONTOLOGY

GSK3β isoform-selective regulation of depression, memory and hippocampal cell proliferation

(2016) M. Pardo et al.   GENES BRAIN AND BEHAVIOR

Neurobehavioural evaluation of resveratrol in murine models of anxiety and schizophrenia

(2016) Mohammed Garba Magaji et al.   METABOLIC BRAIN DISEASE

Developmental Inhibition of Gsk3 Rescues Behavioral and Neurophysiological Deficits in a Mouse Model of Schizophrenia Predisposition

(2016) Makoto Tamura et al.   NEURON

Nucleotides in neuroregeneration and neuroprotection

(2016) M. Teresa Miras-Portugal et al.   NEUROPHARMACOLOGY

Disruption of Akt signaling decreases dopamine sensitivity in modulation of inhibitory synaptic transmission in rat prefrontal cortex

(2016) Yan-Chun Li et al.   NEUROPHARMACOLOGY

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

(2016) A. Licht-Murava et al.   Science Signaling

Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging

(2016) Mukesh K. Pandey et al.   Theranostics

Age-Dependent Switch of the Role of Serotonergic 5-HT1AReceptors in Gating Long-Term Potentiation in Rat Visual CortexIn Vivo

(2016) Peter J. Gagolewicz et al.   NEURAL PLASTICITY

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

(2016) A. Licht-Murava et al.   Science Signaling

Neuroprotective effect of resveratrol against brain ischemia reperfusion injury in rats entails reduction of DJ-1 protein expression and activation of PI3K/Akt/GSK3b survival pathway

(2016) Ghada A. Abdel-Aleem et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Resveratrol Supplementation Did Not Improve Cognition in Patients with Schizophrenia: Results from a Randomized Clinical Trial

(2016) Karine Zortea et al.   Frontiers in Psychiatry

Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus

(2015) Siobhan H. Dennis et al.   CEREBRAL CORTEX

Age-Dependent TDP-43-Mediated Motor Neuron Degeneration Requires GSK3, hat-trick, and xmas-2

(2015) Jemeen Sreedharan et al.   CURRENT BIOLOGY

Activation of m1 muscarinic acetylcholine receptor induces surface transport of KCNQ channels through a CRMP-2-mediated pathway

(2015) L. Jiang et al.   JOURNAL OF CELL SCIENCE

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

(2015) R. Scott Turner et al.   NEUROLOGY

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

Involvement of cellular metabolism in age-related LTP modifications in rat hippocampal slices

(2015) Dominika Drulis-Fajdasz et al.   Oncotarget

Lentiviral silencing of GSK-3β in adult dentate gyrus impairs contextual fear memory and synaptic plasticity

(2015) Benjamin Chew et al.   Frontiers in Behavioral Neuroscience

Mitochondrial Dysfunction in Parkinson's Disease

(2015) Hyo Eun Moon et al.   Experimental Neurobiology

Alzheimer's disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes

(2014) Tiago Silva et al.   AGEING RESEARCH REVIEWS

Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors

(2014) Federica Prati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

GSK-3β dysregulation contributes to parkinson’s-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein

(2014) J J Credle et al.   CELL DEATH AND DIFFERENTIATION

Myelination, oligodendrocytes, and serious mental illness

(2014) V. Haroutunian et al.   GLIA

Dynamic range of GSK3α not GSK3β is essential for bidirectional synaptic plasticity at hippocampal CA3-CA1 synapses

(2014) Lion Shahab et al.   HIPPOCAMPUS

Reflections on glycogen and β-amyloid: why does glycogenolytic β2-adrenoceptor stimulation not rescue memory after β-amyloid?

(2014) Marie Gibbs   METABOLIC BRAIN DISEASE

Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin

(2014) S M Ochs et al.   MOLECULAR PSYCHIATRY

Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP

(2014) Enrica Maria Petrini et al.   Nature Communications

Alpha-synuclein biology in Lewy body diseases

(2014) Woojin Scott Kim et al.   Alzheimers Research & Therapy

Cleavage of GSK-3β by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK-3β activity induced by H2O2

(2013) Ye Feng et al.   JOURNAL OF NEUROCHEMISTRY

β-Amyloid impairs the regulation of N-methyl-D-aspartate receptors by glycogen synthase kinase 3

(2013) Yulei Deng et al.   NEUROBIOLOGY OF AGING

Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments

(2013) Margaret K. King et al.   PHARMACOLOGY & THERAPEUTICS

GSK3B and MAPT Polymorphisms Are Associated with Grey Matter and Intracranial Volume in Healthy Individuals

(2013) Carol Dobson-Stone et al.   PLoS One

Activation of GSK-3β and Caspase-3 Occurs in Nigral Dopamine Neurons during the Development of Apoptosis Activated by a Striatal Injection of 6-Hydroxydopamine

(2013) Daniel Hernandez-Baltazar et al.   PLoS One

FLZ Alleviates the Memory Deficits in Transgenic Mouse Model of Alzheimer’s Disease via Decreasing Beta-Amyloid Production and Tau Hyperphosphorylation

(2013) Xiu-Qi Bao et al.   PLoS One

Glycogen Synthase Kinase-3 Inhibitors as Potent Therapeutic Agents for the Treatment of Parkinson Disease.

(2012) J. A. Morales-García et al.   ACS Chemical Neuroscience

Accumulation of Toxic  -Synuclein Oligomer within Endoplasmic Reticulum Occurs in  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model

(2012) Siva Sundara Kumar Durairajan et al.   NEUROBIOLOGY OF AGING

Neuroglialpharmacology: Myelination as a shared mechanism of action of psychotropic treatments

(2012) George Bartzokis   NEUROPHARMACOLOGY

Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase

(2012) Norelle C. Wildburger et al.   Frontiers in Molecular Neuroscience

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Long-term plasticity at inhibitory synapses

(2011) Pablo E Castillo et al.   CURRENT OPINION IN NEUROBIOLOGY

GSK3 controls axon growth via CLASP-mediated regulation of growth cone microtubules

(2011) E.-M. Hur et al.   GENES & DEVELOPMENT

Effects of lithium on lipopolysaccharide-induced inflammation in rat primary glia cells

(2011) Sigalit Nahman et al.   Innate Immunity

Evidence for Irreversible Inhibition of Glycogen Synthase Kinase-3β by Tideglusib

(2011) Juan Manuel Domínguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice

(2011) W. Timothy O’Brien et al.   JOURNAL OF CLINICAL INVESTIGATION

Glycogen synthase kinase-3β inactivation inhibits tumor necrosis factor-α production in microglia by modulating nuclear factor κB and MLK3/JNK signaling cascades

(2011) Mei-Jen Wang et al.   Journal of Neuroinflammation

A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health

(2011) Jean-Martin Beaulieu   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors

(2011) Haythum O. Tayeb et al.   PHARMACOLOGY & THERAPEUTICS

Genome-Wide Analysis of a Wnt1-Regulated Transcriptional Network Implicates Neurodegenerative Pathways

(2011) E. M. Wexler et al.   Science Signaling

Glycogen Synthase Kinase-3 is an Intermediate Modulator of Serotonin Neurotransmission

(2011) Abigail M. Polter et al.   Frontiers in Molecular Neuroscience

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

(2011) Hagit Eldar-Finkelman et al.   Frontiers in Molecular Neuroscience

Glycogen Synthase Kinase-3 Is an Early Determinant in the Differentiation of Pathogenic Th17 Cells

(2010) E. Beurel et al.   JOURNAL OF IMMUNOLOGY

GSK3  Regulates Myelin-Dependent Axon Outgrowth Inhibition through CRMP4

(2010) Y. Z. Alabed et al.   JOURNAL OF NEUROSCIENCE

GSK-3  Inhibits Presynaptic Vesicle Exocytosis by Phosphorylating P/Q-Type Calcium Channel and Interrupting SNARE Complex Formation

(2010) L.-Q. Zhu et al.   JOURNAL OF NEUROSCIENCE

Regulation of GSK3 isoforms by phosphatases PP1 and PP2A

(2010) Félix Hernández et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles

(2010) Emma L Clayton et al.   NATURE NEUROSCIENCE

Inhibition of neuronal calcium oscillations by cell surface APP phosphorylated on T668

(2010) Susana Ferrao Santos et al.   NEUROBIOLOGY OF AGING

M1 Muscarinic Receptors Boost Synaptic Potentials and Calcium Influx in Dendritic Spines by Inhibiting Postsynaptic SK Channels

(2010) Andrew J. Giessel et al.   NEURON

Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells

(2010) Christian Lange et al.   NEUROSCIENCE LETTERS

GSK3 Influences Social Preference and Anxiety-Related Behaviors during Social Interaction in a Mouse Model of Fragile X Syndrome and Autism

(2010) Marjelo A. Mines et al.   PLoS One

Regulation of GABAergic synapse formation and plasticity by GSK3 -dependent phosphorylation of gephyrin

(2010) S. K. Tyagarajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

Nonprimed and DYRK1A-primed GSK3 -phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons

(2009) T. M. E. Scales et al.   JOURNAL OF CELL SCIENCE

Lithium Trial in Alzheimer's Disease

(2009) Harald Hampel et al.   JOURNAL OF CLINICAL PSYCHIATRY

Calcineurin dephosphorylates glycogen synthase kinase-3 beta at serine-9 in neuroblast-derived cells

(2009) Yeni Kim et al.   JOURNAL OF NEUROCHEMISTRY

Lithium Treatment Decreases Activities of Tau Kinases in a Murine Model of Senescence

(2009) Marta Tajes et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

Expression QTL and regulatory network analysis of microtubule-associated protein tau gene

(2009) Qin Shen et al.   PARKINSONISM & RELATED DISORDERS

Involvment of Cytosolic and Mitochondrial GSK-3β in Mitochondrial Dysfunction and Neuronal Cell Death of MPTP/MPP+-Treated Neurons

(2009) Agnès Petit-Paitel et al.   PLoS One

Akt/GSK3 Signaling in the Action of Psychotropic Drugs

(2008) Jean-Martin Beaulieu et al.   Annual Review of Pharmacology and Toxicology

Upregulation of GSK3β expression in frontal and temporal cortex in ALS with cognitive impairment (ALSci)

(2008) Wencheng Yang et al.   BRAIN RESEARCH

Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity

(2008) Christopher J. Yuskaitis et al.   CELLULAR SIGNALLING

Glycogen Synthase Kinase (GSK) 3β Directly Phosphorylates Serine 212 in the Regulatory Loop and Inhibits Microtubule Affinity-regulating Kinase (MARK) 2

(2008) Thomas Timm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Regulation of STAT Family Members by Glycogen Synthase Kinase-3

(2008) Eléonore Beurel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-β-induced neuronal cell death

(2008) Min-Young Noh et al.   JOURNAL OF NEUROCHEMISTRY

GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals

(2008) Shuxin Hu et al.   NEUROBIOLOGY OF DISEASE

Glycogen synthase kinase-3beta is associated with Parkinson's disease

(2008) Masahiro Nagao et al.   NEUROSCIENCE LETTERS

Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: Novel cytoprotective mechanism against oxidative damage

(2008) Ju Hee Lim et al.   PHARMACOLOGICAL RESEARCH

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE