Article
Chemistry, Multidisciplinary
Zhenyi Hu, Po-Han Chen, Wenxue Li, Todd Douglas, John Hines, Yansheng Liu, Craig M. Crews
Summary: Microtubule-associated protein tau is crucial for microtubule assembly and stabilization. Tau hyperphosphorylation is implicated in the development of Alzheimer's disease and tauopathies. In this study, we used small molecule-based PhosTACs to induce efficient and sustained tau dephosphorylation by recruiting tau to PP2A, a native tau phosphatase. Mass spectrometry data validated that PhosTACs downregulated multiple phosphorylation sites of tau. Our findings suggest that PhosTACs represent a potential avenue for disease-modifying therapies for tauopathies.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Biochemistry & Molecular Biology
Divya M. Teli, Anuradha K. Gajjar
Summary: Elevated glucose level due to β-cell dysfunction is a key marker of Type-II diabetes. GSK-3, an enzyme involved in glycogen metabolism control, has been explored for its potential as a target for diabetes treatment. This review article examines the structural analysis and molecular modeling of GSK-3, as well as advancements in the development of GSK-3 inhibitors as potential therapeutics for Type II diabetes.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Huifang Zhang, Yingchao Han, Ling Zhang, Xiaofang Jia, Qiao Niu
Summary: The neurotoxic effects of aluminum on hippocampal LTP may be mediated through the GSK-3 beta/beta-catenin signaling pathway and involve decreased BDNF expression. In this study, aluminum administration led to suppression of LTP and reduced levels of BDNF, beta-catenin, and phosphorylated GSK-3 beta, which were all reversed by a GSK-3 beta inhibitor.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tianyu Gao, Ce Gao, Zhidong Liu, Yun Wang, Xiaoxia Jia, Hao Tian, Qian Lu, Lin Guo
Summary: Activation of sigma-1 receptor can inhibit microglia activation and neuroinflammation through the non-canonical Ca2+ oscillation/Calcineurin/GSK-3β signaling pathway, which suggests a potential novel anti-inflammatory strategy.
NEUROCHEMICAL RESEARCH
(2022)
Article
Neurosciences
Shaohui Wang, Yao Jiang, Yabo Liu, Qianhui Liu, Hongwei Sun, Mengjie Mei, Xiaomei Liao
Summary: This study demonstrates that ferroptosis promotes abnormal aggregation of tau protein and may serve as a promising therapeutic target for tauopathies.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xinjiang Cai, Yan Zhao, Yang Yang, Xiuju Wu, Li Zhang, Jocelyn A. Ma, Jaden Ji, Kristina I. Bostrom, Yucheng Yao
Summary: Glycogen synthase kinase-3 beta (GSK3 beta) inhibition or endothelial-specific deletion of GSK3 beta reduces atherosclerotic calcification. The changes in beta-catenin and SMAD1 induced by GSK3 beta inhibition in the aortas of Apoe(-/-) mice are similar to Mgp(-/-) mice. This suggests that GSK3 beta inhibition reduces vascular calcification in atherosclerotic lesions through a similar mechanism to that in Mgp(-/-) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jing Wen, Xin Li, Qing-Xia Zhao, Xiao-Fan Yang, Meng-Li Wu, Qihong Yan, Junbiao Chang, Haikun Wang, Xia Jin, Xiao Su, Kai Deng, Ling Chen, Jian-Hua Wang
Summary: In this study, the researchers identified the Wnt downstream beta-catenin/TCF1 pathway as a crucial modulator for HIV-1 latency. Activation of this pathway with GSK3 inhibitors effectively promoted HIV-1 proviral DNA transcription and reactivated latency in CD4(+) T cells.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Fisheries
Xiaotong Sun, Hongtao Nie, Xiwu Yan
Summary: This study identified and investigated three novel glycogen metabolism-related proteins in Manila clam, suggesting their potential involvement in innate immunity and important role in immune defense.
Article
Cell Biology
S. Grace Herod, Annie Dyatel, Stefanie Hodapp, Marko Jovanovic, Luke E. Berchowitz
Summary: Amyloids play important roles in age-related diseases. Some cells use reversible amyloid-like structures for translational control. Yeast 14-3-3 proteins bind to amyloid-like assemblies and facilitate their clearance, contributing to global protein aggregate homeostasis. These findings suggest that 14-3-3 proteins may protect against pathological protein aggregates.
Review
Biochemistry & Molecular Biology
Chia-Ling Chen, Po-Chun Tseng, Rahmat Dani Satria, Thi Thuy Nguyen, Cheng-Chieh Tsai, Chiou-Feng Lin
Summary: GSK-3 is a vital regulator of glycogen synthesis that plays a crucial role in cellular bioregulation. Abnormal GSK-3 activation and inactivation can lead to liver damage. Targeting GSK-3 with drugs is a potential therapeutic approach for liver protection. Additionally, blocking GSK-3 has a protective effect in IFN-gamma-mediated immune hepatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Parisa Badiee, Michelle F. Maritz, Benjamin Thierry
Summary: A nanoformulation of a small molecule GSK3 inhibitor has been developed as a potential alternative to antibody-based checkpoint inhibition. The nanoformulation efficiently inhibits PD-1 expression and improves the survival and proliferation of CAR-T cells, while also increasing the population of memory T cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Maria-Angeles Cortes-Gomez, Esther Llorens-Alvarez, Jordi Alom, Teodoro del Ser, Jesus Avila, Javier Saez-Valero, Maria-Salud Garcia-Ayllon
Summary: This study demonstrates that P-tau can modulate AChE expression, and suggests that AChE may increase in the initial phases of AD.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Immunology
Ricarda Cortes-Vieyra, Octavio Silva-Garcia, Anel Gomez-Garcia, Sergio Gutierrez-Castellanos, Cleto Alvarez-Aguilar, Victor M. Baizabal-Aguirre
Summary: Understanding the regulation of GSK3 beta activity in inflammatory responses caused by pathogenic microorganisms is crucial for controlling the intensity of inflammation. Recent studies have shown that regulating GSK3 beta activity can reduce the detrimental effects of the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Long He, Jennifer Endress, Sungyun Cho, Zhongchi Li, Yuxiang Zheng, John M. Asara, John Blenis
Summary: Serine/one-carbon metabolism plays a critical role in cancer cell growth, but the regulatory mechanisms are not well understood. This study reveals that glycogen synthase kinase 3 (GSK3) plays a key role in regulating the expression of serine/one-carbon metabolic enzymes. Inhibition of nuclear GSK3 signaling enhances the efficacy of serine/one-carbon metabolism inhibitors in suppressing cancer cell proliferation.
Article
Biochemistry & Molecular Biology
Yuko Nagao, Kikuko Amo-Shiinoki, Hiroko Nakabayashi, Masayuki Hatanaka, Manabu Kondo, Kimie Matsunaga, Masahiro Emoto, Shigeru Okuya, Yukio Tanizawa, Katsuya Tanabe
Summary: Endoplasmic reticulum stress is a key pathogenic factor in type 1 and 2 diabetes. Gsk-3 inhibition prevents proteasomal degradation of ATF4 and alleviates apoptosis by regulating phosphorylation of ATF4-S214. Mechanistically, Gsk-3 inhibition modulates transcription targets of ATF4 and facilitates dephosphorylation of eIF2 alpha under ER stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Young-Kwon Park, Limin Wang, Anne Giampietro, Binbin Lai, Ji-Eun Lee, Kai Ge
MOLECULAR AND CELLULAR BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Binbin Lai, Ji-Eun Lee, Younghoon Jang, Lifeng Wang, Weiqun Peng, Kai Ge
NUCLEIC ACIDS RESEARCH
(2017)
Article
Multidisciplinary Sciences
Ji-Eun Lee, Young-Kwon Park, Sarah Park, Younghoon Jang, Nicholas Waring, Anup Dey, Keiko Ozato, Binbin Lai, Weiqun Peng, Kai Ge
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Lenan Zhuang, Younghoon Jang, Young-Kwon Park, Ji-Eun Lee, Shalini Jain, Eugene Froimchuk, Aaron Broun, Chengyu Liu, Oksana Gavrilova, Kai Ge
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Younghoon Jang, Aaron Broun, Chaochen Wang, Young-Kwon Park, Lenan Zhuang, Ji-Eun Lee, Eugene Froimchuk, Chengyu Liu, Kai Ge
NUCLEIC ACIDS RESEARCH
(2019)
Review
Biochemistry & Molecular Biology
Ji-Eun Lee, Hannah Schmidt, Binbin Lai, Kai Ge
MOLECULAR AND CELLULAR BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Yi Zhang, Younghoon Jang, Ji-Eun Lee, JaeWoo Ahn, Longxia Xu, Michael R. Holden, Evan M. Cornett, Krzysztof Krajewski, Brianna J. Klein, Shu-Ping Wang, Yali Dou, Robert G. Roeder, Brian D. Strahl, Scott B. Rothbart, Xiaobing Shi, Kai Ge, Tatiana G. Kutateladze
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Ju-Gyeong Kang, Cory U. Lago, Ji-Eun Lee, Ji-Hoon Park, Matthew P. Donnelly, Matthew F. Starost, Chengyu Liu, Jaeyul Kwon, Audrey C. Noguchi, Kai Ge, Ping-yuan Wang, Paul M. Hwang
Article
Biochemistry & Molecular Biology
Ji-Eun Lee, Young-Wook Cho, Chu-Xia Deng, Kai Ge
MOLECULAR AND CELLULAR BIOLOGY
(2020)
Article
Cell Biology
Consiglia Pacelli, Iolanda Adipietro, Natascia Malerba, Gabriella Maria Squeo, Claudia Piccoli, Angela Amoresano, Gabriella Pinto, Pietro Pucci, Ji-Eun Lee, Kai Ge, Nazzareno Capitanio, Giuseppe Merla
Article
Multidisciplinary Sciences
Young-Kwon Park, Ji-Eun Lee, Zhijiang Yan, Kaitlin McKernan, Tommy O'Haren, Weidong Wang, Weiqun Peng, Kai Ge
Summary: The study reveals that BAF and MLL4 are interdependent in promoting enhancer activation by lineage-determining transcription factors during adipogenesis, providing a positive feedback mechanism for the activation of cell type-specific enhancers.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Younghoon Jang, Young-Kwon Park, Ji-Eun Lee, Danyang Wan, Nhien Tran, Oksana Gavrilova, Kai Ge
Summary: Our study reveals that MED1 is not generally required for transcription during adipogenesis, but plays a crucial role in postnatal adipose expansion and induction of lipid synthesis genes after diet switch.
GENES & DEVELOPMENT
(2021)
Article
Cell Biology
Jihong Cui, Chi Zhang, Ji-Eun Lee, Boris A. Bartholdy, Dapeng Yang, Yu Liu, Piril Erler, Phillip M. Galbo Jr, Dayle Q. Hodge, Danwei Huangfu, Deyou Zheng, Kai Ge, Wenjun Guo
Summary: In this study, it was found that deletion of the epigenetic regulator MLL3 promotes the acquisition of hybrid EMT in breast cancer cells, leading to increased metastasis. MLL3 loss enhances responses to stimuli inducing EMT and mesenchymal-epithelial transition in epithelial and mesenchymal cells, respectively. Mechanistically, MLL3 loss increases IFN gamma signaling, contributing to the induction of hybrid EMT cells and enhanced metastatic capacity.
NATURE CELL BIOLOGY
(2023)
Article
Genetics & Heredity
Guojia Xie, Ji-Eun Lee, Anna D. Senft, Young-Kwon Park, Younghoon Jang, Shreeta Chakraborty, Joyce J. J. Thompson, Kaitlin McKernan, Chengyu Liu, Todd S. S. Macfarlan, Pedro P. P. Rocha, Weiqun Peng, Kai Ge
Summary: The enzymatic activities of MLL3 and MLL4 are critical for embryonic development and embryonic stem cell differentiation.
Article
Immunology
Katarzyna Placek, Gangqing Hu, Kairong Cui, Dunfang Zhang, Yi Ding, Ji-Eun Lee, Younghoon Jang, Chaochen Wang, Joanne Elizabeth Konkel, Jiuzhou Song, Chengyu Liu, Kai Ge, Wanjun Chen, Keji Zhao
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)