Placental growth factor in cancer

Role of Inflammation-Associated Microenvironment in Tumorigenesis and Metastasis

(2014) Feng Gao et al.   CURRENT CANCER DRUG TARGETS

Epigenetic control of hypoxia inducible factor-1α-dependent expression of placental growth factor in hypoxic conditions

(2014) Laura Tudisco et al.   Epigenetics

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

(2014) M. M. Martino et al.   SCIENCE

Antiangiogenesis therapy: an update after the first decade

(2014) Sandro De Falco   KOREAN JOURNAL OF INTERNAL MEDICINE

Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo

(2013) Nadine Jetten et al.   ANGIOGENESIS

Pazopanib exposure decreases as a result of an ifosfamide-dependent drug–drug interaction: results of a phase I study

(2013) P Hamberg et al.   BRITISH JOURNAL OF CANCER

Targeting Placental Growth Factor/Neuropilin 1 Pathway Inhibits Growth and Spread of Medulloblastoma

(2013) Matija Snuderl et al.   CELL

A Phase II and Biomarker Study of Ramucirumab, a Human Monoclonal Antibody Targeting the VEGF Receptor-2, as First-Line Monotherapy in Patients with Advanced Hepatocellular Cancer

(2013) A. X. Zhu et al.   CLINICAL CANCER RESEARCH

Efficacy, Safety, Pharmacokinetics, and Biomarkers of Cediranib Monotherapy in Advanced Hepatocellular Carcinoma: A Phase II Study

(2013) A. X. Zhu et al.   CLINICAL CANCER RESEARCH

Aflibercept

(2013) K. K. Ciombor et al.   CLINICAL CANCER RESEARCH

Placental growth factor supports neuroendocrine tumor growth and predicts disease prognosis in patients

(2013) Georg Hilfenhaus et al.   ENDOCRINE-RELATED CANCER

Inhibition of Stromal PlGF Suppresses the Growth of Prostate Cancer Xenografts

(2013) Karin Zins et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteolytic Processing Regulates Placental Growth Factor Activities

(2013) Daniel C. Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Placental Growth Factor (PlGF)-Specific Uptake in Tumor Microenvironment of 89Zr-Labeled PlGF Antibody RO5323441

(2013) T. H. Oude Munnink et al.   JOURNAL OF NUCLEAR MEDICINE

The Association of Alternate VEGF Ligands with Resistance to Anti-VEGF Therapy in Metastatic Colorectal Cancer

(2013) Christopher H. Lieu et al.   PLoS One

Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth

(2013) Xiaojuan Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor-1 Ligands

(2013) A. Anisimov et al.   Science Signaling

PlGF: A Multitasking Cytokine with Disease-Restricted Activity

(2013) M. Dewerchin et al.   Cold Spring Harbor Perspectives in Medicine

A phase I study of ABT-510 plus bevacizumab in advanced solid tumors

(2013) Hope E. Uronis et al.   Cancer Medicine

Prognostic impact of placenta growth factor and vascular endothelial growth factor A in patients with breast cancer

(2012) Else Maae et al.   BREAST CANCER RESEARCH AND TREATMENT

Hepatocyte-Stellate Cell Cross-Talk in the Liver Engenders a Permissive Inflammatory Microenvironment That Drives Progression in Hepatocellular Carcinoma

(2012) C. Coulouarn et al.   CANCER RESEARCH

A Phase I Trial and Pharmacokinetic Study of Aflibercept (VEGF Trap) in Children with Refractory Solid Tumors: A Children's Oncology Group Phase I Consortium Report

(2012) J. G. Bender et al.   CLINICAL CANCER RESEARCH

Inhibition of the placental growth factor decreases burden of cholangiocarcinoma and hepatocellular carcinoma in a transgenic mouse model

(2012) Femke Heindryckx et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Role of placenta growth factor in cancer and inflammation

(2012) Ki-Jo Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The discovery of placenta growth factor and its biological activity

(2012) Sandro De Falco   EXPERIMENTAL AND MOLECULAR MEDICINE

Inhibition of placenta growth factor with TB-403: a novel antiangiogenic cancer therapy

(2012) Dorte Lisbet Nielsen et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Tumor associated macrophages and neutrophils in tumor progression

(2012) Maria R. Galdiero et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model

(2012) Femke Heindryckx et al.   JOURNAL OF HEPATOLOGY

Increased placenta growth factor mRNA level is significantly associated with progression, recurrence and poor prognosis of oral squamous cell carcinoma

(2012) Shih-Jung Cheng et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

CD105 and placental growth factor – Potent prognostic factors in childhood acute lymphoblastic leukaemia

(2012) Patrycja Sujka-Kordowska et al.   LEUKEMIA RESEARCH

Exploratory investigation of eight circulating plasma markers in brain tumor patients

(2012) Aysegul Ilhan-Mutlu et al.   NEUROSURGICAL REVIEW

Elevated PLGF contributes to small-cell lung cancer brain metastasis

(2012) B Li et al.   ONCOGENE

Efficacy, Safety, and Biomarkers of Single-Agent Bevacizumab Therapy in Patients with Advanced Hepatocellular Carcinoma

(2012) V. Boige et al.   ONCOLOGIST

Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs

(2012) E.-M. E. Hedlund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis

(2012) Melissa J. Cudmore et al.   Nature Communications

Correlation of Circulating Angiogenic Factors with Circulating Tumor Cells and Disease Recurrence in Patients Undergoing Curative Resection for Colorectal Liver Metastases

(2011) Nuh N. Rahbari et al.   ANNALS OF SURGICAL ONCOLOGY

Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer

(2011) Nuh N Rahbari et al.   BMC CANCER

Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer

(2011) F Loupakis et al.   BRITISH JOURNAL OF CANCER

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia

(2011) Thomas Schmidt et al.   CANCER CELL

Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors

(2011) J. Laurent et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Myeloid Biomarkers Associated with Glioblastoma Response to Anti-VEGF Therapy with Aflibercept

(2011) J. F. de Groot et al.   CLINICAL CANCER RESEARCH

Placental Growth Factor Upregulation Is a Host Response to Antiangiogenic Therapy

(2011) R. G. Bagley et al.   CLINICAL CANCER RESEARCH

Phase I/II and Pharmacodynamic Study of Dovitinib (TKI258), an Inhibitor of Fibroblast Growth Factor Receptors and VEGF Receptors, in Patients with Advanced Melanoma

(2011) K. B. Kim et al.   CLINICAL CANCER RESEARCH

Monoclonal Antibody TB-403: A First-in-Human, Phase I, Double-Blind, Dose Escalation Study Directed Against Placental Growth Factor in Healthy Male Subjects

(2011) Titti Martinsson-Niskanen et al.   CLINICAL THERAPEUTICS

A phase II study of aflibercept in patients with advanced epithelial ovarian cancer and symptomatic malignant ascites

(2011) Nicoletta Colombo et al.   GYNECOLOGIC ONCOLOGY

Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice

(2011) Christophe Van Steenkiste et al.   HEPATOLOGY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

HCC and angiogenesis: possible targets and future directions

(2011) Andrew X. Zhu et al.   Nature Reviews Clinical Oncology

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Placenta Growth Factor-1 Exerts Time-Dependent Stabilization of Adherens Junctions Following VEGF-Induced Vascular Permeability

(2011) Jun Cai et al.   PLoS One

Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy

(2011) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiogenesis: A Target in Solid Tumors, Also in Leukemia?

(2011) T. Schmidt et al.   Hematology-American Society of Hematology Education Program

Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model

(2010) Sandra R. Brave et al.   ANGIOGENESIS

Placental growth factor (PlGF) enhances breast cancer cell motility by mobilising ERK1/2 phosphorylation and cytoskeletal rearrangement

(2010) A P Taylor et al.   BRITISH JOURNAL OF CANCER

Premetastatic Lung "Niche": Is Vascular Endothelial Growth Factor Receptor 1 Activation Required?

(2010) D. G. Duda et al.   CANCER RESEARCH

Anti-Placental Growth Factor Reduces Bone Metastasis by Blocking Tumor Cell Engraftment and Osteoclast Differentiation

(2010) L. Coenegrachts et al.   CANCER RESEARCH

A Placental Growth Factor Variant Unable to Recognize Vascular Endothelial Growth Factor (VEGF) Receptor-1 Inhibits VEGF-Dependent Tumor Angiogenesis via Heterodimerization

(2010) V. Tarallo et al.   CANCER RESEARCH

PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth

(2010) Carlos Bais et al.   CELL

Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease

(2010) Sara Van de Veire et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Evading tumor evasion: Current concepts and perspectives of anti-angiogenic cancer therapy

(2010) Amir Abdollahi et al.   DRUG RESISTANCE UPDATES

Expression of placenta growth factor: An independent factor for prediction of progression and prognosis of oral cancer

(2010) Shih-Jung Cheng et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Expression and prognostic significance of placental growth factor in hepatocellular carcinoma and peritumoral liver tissue

(2010) Hua-Xiang Xu et al.   INTERNATIONAL JOURNAL OF CANCER

Biomarkers as Predictors of Response to Treatment with Motesanib in Patients with Progressive Advanced Thyroid Cancer

(2010) Michael B. Bass et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

NFAT1 Mediates Placental Growth Factor-Induced Myelomonocytic Cell Recruitment via the Induction of TNF - α

(2010) Yanping Ding et al.   JOURNAL OF IMMUNOLOGY

Vascular endothelial growth factor B controls endothelial fatty acid uptake

(2010) Carolina E. Hagberg et al.   NATURE

Ribosome Display and Selection of Human Anti-Placental Growth Factor scFv Derived from Ovarian Cancer Patients

(2010) Fang Li et al.   PROTEIN AND PEPTIDE LETTERS

"Antimyeloangiogenic" Therapy for Cancer by Inhibiting PlGF

(2009) S. Loges et al.   CLINICAL CANCER RESEARCH

Efficacy, Safety, and Potential Biomarkers of Sunitinib Monotherapy in Advanced Hepatocellular Carcinoma: A Phase II Study

(2009) Andrew X. Zhu et al.   JOURNAL OF CLINICAL ONCOLOGY

Kaplan et al. reply

(2009) Rosandra N. Kaplan et al.   NATURE

VEGFR1-activity-independent metastasis formation

(2009) Michelle R. Dawson et al.   NATURE

Biomarkers of response and resistance to antiangiogenic therapy

(2009) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

VEGFR1 Activity Modulates Myeloid Cell Infiltration in Growing Lung Metastases but Is Not Required for Spontaneous Metastasis Formation

(2009) Michelle R. Dawson et al.   PLoS One

Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature

(2009) E.-M. Hedlund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Measurement of Phosphorylated Extracellular Signal-Regulated Kinase 1 and 2 in an Undergraduate Teaching Laboratory with ALPHAscreen Technology

(2009) D. L. Hay   Science Signaling

Flt-1 Signaling in Macrophages Promotes Glioma Growth In vivo

(2008) M. Kerber et al.   CANCER RESEARCH

Antitumor Activity and Biomarker Analysis of Sunitinib in Patients With Bevacizumab-Refractory Metastatic Renal Cell Carcinoma

(2008) Brian I. Rini et al.   JOURNAL OF CLINICAL ONCOLOGY

Development of targeted angiogenic medicine

(2008) S. LOGES et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS