The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor-1 Ligands

PlGF: A Multitasking Cytokine with Disease-Restricted Activity

(2013) M. Dewerchin et al.   Cold Spring Harbor Perspectives in Medicine

The discovery of placenta growth factor and its biological activity

(2012) Sandro De Falco   EXPERIMENTAL AND MOLECULAR MEDICINE

Targeting Extracellular Domains D4 and D7 of Vascular Endothelial Growth Factor Receptor 2 Reveals Allosteric Receptor Regulatory Sites

(2012) C. A. C. Hyde et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R

(2012) Xiaolei Ma et al.   STRUCTURE

The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis

(2012) Melissa J. Cudmore et al.   Nature Communications

Developmental and Pathological Angiogenesis

(2011) Alicia S. Chung et al.   Annual Review of Cell and Developmental Biology

Signal transduction by vascular endothelial growth factor receptors

(2011) Sina Koch et al.   BIOCHEMICAL JOURNAL

Taming of the wild vessel: promoting vessel stabilization for safe therapeutic angiogenesis: Figure 1

(2011) Silvia Reginato et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization

(2011) M. S. Brozzo et al.   BLOOD

Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering

(2011) Kaisa Kisko et al.   FASEB JOURNAL

Progress and prospects: hurdles to cardiovascular gene therapy clinical trials

(2011) M Hedman et al.   GENE THERAPY

An Antibody Targeted to VEGFR-2 Ig Domains 4-7 Inhibits VEGFR-2 Activation and VEGFR-2-Dependent Angiogenesis without Affecting Ligand Binding

(2011) J. Kendrew et al.   MOLECULAR CANCER THERAPEUTICS

Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy

(2011) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effective Suppression of Vascular Network Formation by Combination of Antibodies Blocking VEGFR Ligand Binding and Receptor Dimerization

(2010) Denis Tvorogov et al.   CANCER CELL

A Placental Growth Factor Variant Unable to Recognize Vascular Endothelial Growth Factor (VEGF) Receptor-1 Inhibits VEGF-Dependent Tumor Angiogenesis via Heterodimerization

(2010) V. Tarallo et al.   CANCER RESEARCH

PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth

(2010) Carlos Bais et al.   CELL

Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease

(2010) Sara Van de Veire et al.   CELL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation

(2010) T Chihara et al.   CELL DEATH AND DIFFERENTIATION

Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation

(2010) Maija Bry et al.   CIRCULATION

Structural Insights into the Binding of Vascular Endothelial Growth Factor-B by VEGFR-1D2

(2010) Shalini Iyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppressive Effects of Vascular Endothelial Growth Factor-B on Tumor Growth in a Mouse Model of Pancreatic Neuroendocrine Tumorigenesis

(2010) Imke Albrecht et al.   PLoS One

Structural determinants of growth factor binding and specificity by VEGF receptor 2

(2010) V.-M. Leppanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex

(2010) A. Hye-Ryong Shim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling

(2010) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular Endothelial Growth Factor-B Induces Myocardium-Specific Angiogenesis and Arteriogenesis via Vascular Endothelial Growth Factor Receptor-1– and Neuropilin Receptor-1–Dependent Mechanisms

(2009) Johanna E. Lähteenvuo et al.   CIRCULATION

Activated Forms of VEGF-C and VEGF-D Provide Improved Vascular Function in Skeletal Muscle

(2009) Andrey Anisimov et al.   CIRCULATION RESEARCH

Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands

(2009) Y. Cao   Science Signaling

Hematopoietic cytokines

(2008) D. Metcalf   BLOOD