Inhibition of placenta growth factor with TB-403: a novel antiangiogenic cancer therapy

Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia

(2011) Thomas Schmidt et al.   CANCER CELL

Abstract 1370: RO5323441, a humanized monoclonal antibody against the placenta growth factor, blocks PlGF-induced VEGFR-1 phosphorylation in vitro and tumor growth in vivo

(2011) Christine Rizzo et al.   CANCER RESEARCH

Monoclonal Antibody TB-403: A First-in-Human, Phase I, Double-Blind, Dose Escalation Study Directed Against Placental Growth Factor in Healthy Male Subjects

(2011) Titti Martinsson-Niskanen et al.   CLINICAL THERAPEUTICS

Preoperative Serum Placenta Growth Factor Level Is a Prognostic Biomarker in Colorectal Cancer

(2011) Shu-Chen Wei et al.   DISEASES OF THE COLON & RECTUM

Bevacizumab Treatment for Solid Tumors

(2011) Daniel F. Hayes   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Angiogenesis: A Target in Solid Tumors, Also in Leukemia?

(2011) T. Schmidt et al.   Hematology-American Society of Hematology Education Program

Placental growth factor (PlGF) enhances breast cancer cell motility by mobilising ERK1/2 phosphorylation and cytoskeletal rearrangement

(2010) A P Taylor et al.   BRITISH JOURNAL OF CANCER

Final Results of a Phase II Trial Evaluating Trastuzumab and Bevacizumab as First Line Treatment of HER2-Amplified Advanced Breast Cancer.

(2010) S. Hurvitz et al.   CANCER RESEARCH

Anti-Placental Growth Factor Reduces Bone Metastasis by Blocking Tumor Cell Engraftment and Osteoclast Differentiation

(2010) L. Coenegrachts et al.   CANCER RESEARCH

A Placental Growth Factor Variant Unable to Recognize Vascular Endothelial Growth Factor (VEGF) Receptor-1 Inhibits VEGF-Dependent Tumor Angiogenesis via Heterodimerization

(2010) V. Tarallo et al.   CANCER RESEARCH

PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth

(2010) Carlos Bais et al.   CELL

Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease

(2010) Sara Van de Veire et al.   CELL

Bevacizumab: current updates in treatment

(2010) Margaret EM Van Meter et al.   CURRENT OPINION IN ONCOLOGY

Antiangiogenesis agents in colorectal cancer

(2010) Joleen Hubbard et al.   CURRENT OPINION IN ONCOLOGY

Mechanisms of resistance to antiangiogenesis therapy

(2010) Faisal Azam et al.   EUROPEAN JOURNAL OF CANCER

Expression of placenta growth factor: An independent factor for prediction of progression and prognosis of oral cancer

(2010) Shih-Jung Cheng et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Expression and prognostic significance of placental growth factor in hepatocellular carcinoma and peritumoral liver tissue

(2010) Hua-Xiang Xu et al.   INTERNATIONAL JOURNAL OF CANCER

Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals

(2009) Xiang H.-F. Zhang et al.   CANCER CELL

Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions

(2009) C. Roncal et al.   CARDIOVASCULAR RESEARCH

"Antimyeloangiogenic" Therapy for Cancer by Inhibiting PlGF

(2009) S. Loges et al.   CLINICAL CANCER RESEARCH

VEGFs and receptors involved in angiogenesis versus lymphangiogenesis

(2009) Marja Lohela et al.   CURRENT OPINION IN CELL BIOLOGY

Pathways mediating VEGF-independent tumor angiogenesis

(2009) Napoleone Ferrara   CYTOKINE & GROWTH FACTOR REVIEWS

Current status and future prospects for anti-angiogenic therapies in cancer

(2009) Carolyn A Staton et al.   Expert Opinion on Drug Discovery

Phase II Trial of Infusional Fluorouracil, Irinotecan, and Bevacizumab for Metastatic Colorectal Cancer: Efficacy and Circulating Angiogenic Biomarkers Associated With Therapeutic Resistance

(2009) Scott Kopetz et al.   JOURNAL OF CLINICAL ONCOLOGY

VEGFR1-activity-independent metastasis formation

(2009) Michelle R. Dawson et al.   NATURE

VEGFR1 Activity Modulates Myeloid Cell Infiltration in Growing Lung Metastases but Is Not Required for Spontaneous Metastasis Formation

(2009) Michelle R. Dawson et al.   PLoS One

Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands

(2009) Y. Cao   Science Signaling

Drug resistance associated with antiangiogenesis therapy

(2009) Hans Petter Eikesdal et al.   SEMINARS IN CANCER BIOLOGY

VEGF receptor protein–tyrosine kinases: Structure and regulation

(2008) Robert Roskoski   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of choroidal neovascularization by blocking vascular endothelial growth factor receptor tyrosine kinase

(2008) Junko Kami et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

Antitumor Activity and Biomarker Analysis of Sunitinib in Patients With Bevacizumab-Refractory Metastatic Renal Cell Carcinoma

(2008) Brian I. Rini et al.   JOURNAL OF CLINICAL ONCOLOGY

Bevacizumab Beyond First Progression Is Associated With Prolonged Overall Survival in Metastatic Colorectal Cancer: Results From a Large Observational Cohort Study (BRiTE)

(2008) Axel Grothey et al.   JOURNAL OF CLINICAL ONCOLOGY

Basic Science Review: Current Insights on the Biology and Clinical Aspects of VEGF Regulation

(2008) Daniel M. Birk et al.   Vascular and Endovascular Surgery

Combined targeting of EGFR-dependent and VEGF-dependent pathways: rationale, preclinical studies and clinical applications

(2008) Giampaolo Tortora et al.   Nature clinical practice. Oncology