Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy

Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1

(2015) Julie S. Barber-Rotenberg et al.   Oncotarget

Pharmacokinetic modeling optimizes inhibition of the ‘undruggable’ EWS-FLI1 transcription factor in Ewing Sarcoma

(2015) Sung-Hyeok Hong et al.   Oncotarget

Ecteinascidin 743 Interferes with the Activity of EWS-FLI1 in Ewing Sarcoma Cells

(2015) Patrick J. Grohar et al.   NEOPLASIA

EWS-FLI-1 regulates the neuronal repressor gene REST, which controls Ewing sarcoma growth and vascular morphology

(2014) Zhichao Zhou et al.   CANCER

Long-term cause-specific mortality in survivors of adolescent and young adult bone and soft tissue sarcoma: A population-based study of 28,844 patients

(2014) Paul Youn et al.   CANCER

Ewing’s sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors

(2014) Miwa Tanaka et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

(2014) Robert Huether et al.   Nature Communications

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Molecular Pathways: SWI/SNF (BAF) Complexes Are Frequently Mutated in Cancer--Mechanisms and Potential Therapeutic Insights

(2013) X. Wang et al.   CLINICAL CANCER RESEARCH

Functional epigenetic approach identifies frequently methylated genes in Ewing sarcoma

(2013) Abdullah Alholle et al.   Epigenetics

Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer

(2013) Sven Bilke et al.   GENOME RESEARCH

Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial

(2013) Gary K Schwartz et al.   LANCET ONCOLOGY

Combining PARP-1 Inhibition and Radiation in Ewing Sarcoma Results in Lethal DNA Damage

(2013) Hae-June Lee et al.   MOLECULAR CANCER THERAPEUTICS

Pharmacologic inhibition of epigenetic modification reveals targets of aberrant promoter methylation in ewing sarcoma

(2013) Shawnagay Nestheide et al.   PEDIATRIC BLOOD & CANCER

Phase 2 trial of cixutumumab in children, adolescents, and young adults with refractory solid tumors: A report from the Children's Oncology Group

(2013) Brenda Weigel et al.   PEDIATRIC BLOOD & CANCER

Preclinical evaluation of the PARP inhibitor, olaparib, in combination with cytotoxic chemotherapy in pediatric solid tumors

(2013) Robin E. Norris et al.   PEDIATRIC BLOOD & CANCER

FOXM1 Is an Oncogenic Mediator in Ewing Sarcoma

(2013) Laura Christensen et al.   PLoS One

BCL11B Is Up-Regulated by EWS/FLI and Contributes to the Transformed Phenotype in Ewing Sarcoma

(2013) Elizabeth T. Wiles et al.   PLoS One

Lysyl Oxidase Is Downregulated by the EWS/FLI1 Oncoprotein and Its Propeptide Domain Displays Tumor Supressor Activities in Ewing Sarcoma Cells

(2013) Noelia Agra et al.   PLoS One

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Late effects of chemotherapy and radiotherapy in osteosarcoma and Ewing sarcoma patients

(2012) Alessandra Longhi et al.   CANCER

Targeting the EWSR1-FLI1 Oncogene-Induced Protein Kinase PKC-  Abolishes Ewing Sarcoma Growth

(2012) D. Surdez et al.   CANCER RESEARCH

PARP-1 Inhibition as a Targeted Strategy to Treat Ewing's Sarcoma

(2012) J. C. Brenner et al.   CANCER RESEARCH

Insulin Growth Factor-Receptor (IGF-1R) Antibody Cixutumumab Combined with the mTOR Inhibitor Temsirolimus in Patients with Refractory Ewing's Sarcoma Family Tumors

(2012) A. Naing et al.   CLINICAL CANCER RESEARCH

Small-molecule screen identifies modulators of EWS/FLI1 target gene expression and cell survival in Ewing's sarcoma

(2012) Aleksandar Boro et al.   INTERNATIONAL JOURNAL OF CANCER

Phase II Study of Ganitumab, a Fully Human Anti–Type-1 Insulin-Like Growth Factor Receptor Antibody, in Patients With Metastatic Ewing Family Tumors or Desmoplastic Small Round Cell Tumors

(2012) William D. Tap et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification of Common and Distinctive Mechanisms of Resistance to Different Anti-IGF-IR Agents in Ewing's Sarcoma

(2012) Cecilia Garofalo et al.   MOLECULAR ENDOCRINOLOGY

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma

(2012) S Sankar et al.   ONCOGENE

Ewing Sarcoma: Clinical State-of-the-Art

(2012) Jenny Potratz et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

Influence of the Internalization Pathway on the Efficacy of siRNA Delivery by Cationic Fluorescent Nanodiamonds in the Ewing Sarcoma Cell Model

(2012) Anna Alhaddad et al.   PLoS One

 -Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma

(2012) H. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity

(2012) Silke Schlottmann et al.   Frontiers in Oncology

Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors

(2011) Peter C. Hollenhorst et al.   Annual Review of Biochemistry

Phase I Study of PARP Inhibitor ABT-888 in Combination with Topotecan in Adults with Refractory Solid Tumors and Lymphomas

(2011) S. Kummar et al.   CANCER RESEARCH

Microsatellites are EWS/FLI response elements: Genomic "junk" is EWS/FLI's treasure

(2011) Kunal Gangwal et al.   CELL CYCLE

Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors

(2011) Hayriye V. Erkizan et al.   CELL CYCLE

A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis

(2011) S. W. Leacock et al.   Disease Models & Mechanisms

Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription

(2011) M. Patel et al.   GENOME RESEARCH

Oncogenic Fusion Protein EWS/FLI1 Down-regulates Gene Expression by Both Transcriptional and Posttranscriptional Mechanisms

(2011) Kelly A. France et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study

(2011) Alberto S. Pappo et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I/II Trial and Pharmacokinetic Study of Cixutumumab in Pediatric Patients With Refractory Solid Tumors and Ewing Sarcoma: A Report From the Children's Oncology Group

(2011) Suman Malempati et al.   JOURNAL OF CLINICAL ONCOLOGY

Efficacy of Ganitumab (AMG 479), Alone and in Combination with Rapamycin, in Ewing's and Osteogenic Sarcoma Models

(2011) P. J. Beltran et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Identification of an Inhibitor of the EWS-FLI1 Oncogenic Transcription Factor by High-Throughput Screening

(2011) Patrick J. Grohar et al.   JNCI-Journal of the National Cancer Institute

A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs

(2011) E L McKinsey et al.   ONCOGENE

YK-4-279 Inhibits ERG and ETV1 Mediated Prostate Cancer Cell Invasion

(2011) Said Rahim et al.   PLoS One

IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis

(2011) Ana Sofia Martins et al.   PLoS One

Targeted Morphoproteomic Profiling of Ewing's Sarcoma Treated with Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors: Response/Resistance Signatures

(2011) Vivek Subbiah et al.   PLoS One

Modeling Initiation of Ewing Sarcoma in Human Neural Crest Cells

(2011) Cornelia von Levetzow et al.   PLoS One

Let-7a Is a Direct EWS-FLI-1 Target Implicated in Ewing's Sarcoma Development

(2011) Claudio De Vito et al.   PLoS One

R1507, an Anti-Insulin-Like Growth Factor-1 Receptor (IGF-1R) Antibody, and EWS/FLI-1 siRNA in Ewing's Sarcoma: Convergence at the IGF/IGFR/Akt Axis

(2011) Helen J. Huang et al.   PLoS One

Nanodiamond as a Vector for siRNA Delivery to Ewing Sarcoma Cells

(2011) Anna Alhaddad et al.   Small

Promiscuous partnerships in Ewing's sarcoma

(2011) Savita Sankar et al.   Cancer Genetics

FOXO1 is a direct target of EWS-Fli1 oncogenic fusion protein in Ewing’s sarcoma cells

(2010) Liu Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Platelet-derived growth factor receptor β inhibition increases tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity

(2010) Yongxin Wang et al.   CANCER

Aetiology of childhood leukaemia

(2010) Tim Eden   CANCER TREATMENT REVIEWS

A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature

(2010) Jeffrey D. Hancock et al.   CELL CYCLE

Targeting insulin-like growth factor 1 receptor in sarcomas

(2010) Katia Scotlandi et al.   CURRENT OPINION IN ONCOLOGY

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo

(2010) Gong-Hong Wei et al.   EMBO JOURNAL

EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells

(2010) N. Riggi et al.   GENES & DEVELOPMENT

Synthetic siRNA targeting the breakpoint of EWS/Fli-1 inhibits growth of Ewing sarcoma xenografts in a mouse model

(2010) Iori Takigami et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of the Insulin-Like Growth Factor I Receptor by Epigallocatechin Gallate Blocks Proliferation and Induces the Death of Ewing Tumor Cells

(2010) H.-G. Kang et al.   MOLECULAR CANCER THERAPEUTICS

ABT-869 Inhibits the Proliferation of Ewing Sarcoma Cells and Suppresses Platelet-Derived Growth Factor Receptor   and c-KIT Signaling Pathways

(2010) A. K. Ikeda et al.   MOLECULAR CANCER THERAPEUTICS

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program

(2010) E. Anders Kolb et al.   PEDIATRIC BLOOD & CANCER

Downstream EWS/FLI1 - upstream Ewing's sarcoma

(2010) Heinrich Kovar   Genome Medicine

The Insulin-like Growth Factor-1 Receptor-Targeting Antibody, CP-751,871, Suppresses Tumor-Derived VEGF and Synergizes with Rapamycin in Models of Childhood Sarcoma

(2009) R. T. Kurmasheva et al.   CANCER RESEARCH

EWS/FLI and Its Downstream Target NR0B1 Interact Directly to Modulate Transcription and Oncogenesis in Ewing's Sarcoma

(2009) M. Kinsey et al.   CANCER RESEARCH

GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein

(2009) Elspeth Beauchamp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical Model

(2009) Rashmi Chugh et al.   JOURNAL OF CLINICAL ONCOLOGY

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

(2009) Hayriye V Erkizan et al.   NATURE MEDICINE

GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance

(2009) W Luo et al.   ONCOGENE

O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing's sarcoma

(2009) R Bachmaier et al.   ONCOGENE

Health status at long-term follow-up in patients treated for extremity localized Ewing Sarcoma or osteosarcoma: A Scandinavian sarcoma group study

(2009) L.H. Aksnes et al.   PEDIATRIC BLOOD & CANCER

Differences in activities of daily living performance between long-term pediatric sarcoma survivors and a matched comparison group on standardized testing

(2009) Rebecca Parks et al.   PEDIATRIC BLOOD & CANCER

The Oncogenic EWS-FLI1 Protein Binds In Vivo GGAA Microsatellite Sequences with Potential Transcriptional Activation Function

(2009) Noëlle Guillon et al.   PLoS One

A Molecular Function Map of Ewing's Sarcoma

(2009) Maximilian Kauer et al.   PLoS One

EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

(2009) G. H. S. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsic Structural Disorder Confers Cellular Viability on Oncogenic Fusion Proteins

(2009) Hedi Hegyi et al.   PLoS Computational Biology

Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage

(2008) Iva V. Klevernic et al.   BIOCHEMICAL JOURNAL

EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells

(2008) N. Riggi et al.   CANCER RESEARCH

EWS-FLI1 Induces Developmental Abnormalities and Accelerates Sarcoma Formation in a Transgenic Mouse Model

(2008) Patrick P. Lin et al.   CANCER RESEARCH

Changes in Incidence and Survival of Ewing Sarcoma Patients Over the Past 3 Decades

(2008) Natia Esiashvili et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors

(2008) Gary Potikyan et al.   LABORATORY INVESTIGATION

DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells

(2008) E García-Aragoncillo et al.   ONCOGENE

Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program

(2008) E. Anders Kolb et al.   PEDIATRIC BLOOD & CANCER

Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: A report from the Children's Oncology Group

(2008) Steven G. DuBois et al.   PEDIATRIC BLOOD & CANCER

EWS/FLI Mediates Transcriptional Repression via NKX2.2 during Oncogenic Transformation in Ewing's Sarcoma

(2008) Leah A. Owen et al.   PLoS One

IGF1 Is a Common Target Gene of Ewing's Sarcoma Fusion Proteins in Mesenchymal Progenitor Cells

(2008) Luisa Cironi et al.   PLoS One

Microsatellites as EWS/FLI response elements in Ewing's sarcoma

(2008) K. Gangwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EWS-FLI1 Causes Neuroepithelial Defects and Abrogates Emigration of Neural Crest Stem Cells

(2008) Edward G. Coles et al.   STEM CELLS