Small molecules aimed at type III secretion systems to inhibit bacterial virulence

The Type III Secretion System as a Source of Novel Antibacterial Drug Targets

(2012) Toni Kline et al.   CURRENT DRUG TARGETS

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

Identification of Bacterial Target Proteins for the Salicylidene Acylhydrazide Class of Virulence-blocking Compounds

(2011) Dai Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chlamydia trachomatis secretion of hypothetical protein CT622 into host cell cytoplasm via a secretion pathway that can be inhibited by the type III secretion system inhibitor compound 1

(2011) S. Gong et al.   MICROBIOLOGY-SGM

Shifting the balance: antibiotic effects on host–microbiota mutualism

(2011) Benjamin P. Willing et al.   NATURE REVIEWS MICROBIOLOGY

Identification of Small-Molecule Inhibitors of Yersinia pestis Type III Secretion System YscN ATPase

(2011) Wieslaw Swietnicki et al.   PLoS One

A Sorting Platform Determines the Order of Protein Secretion in Bacterial Type III Systems

(2011) M. Lara-Tejero et al.   SCIENCE

Three-Dimensional Model of Salmonella's Needle Complex at Subnanometer Resolution

(2011) O. Schraidt et al.   SCIENCE

Biogenesis, Regulation, and Targeting of the Type III Secretion System

(2011) Thierry Izoré et al.   STRUCTURE

Identification and Characterization of Small-Molecule Inhibitors of Yop Translocation in Yersinia pseudotuberculosis

(2010) D. E. Harmon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery and Characterization of Inhibitors of Pseudomonas aeruginosa Type III Secretion

(2010) D. Aiello et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gram-negative bacterium Yersinia

(2010) Markus K. Dahlgren et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium

(2010) Kyota Kimura et al.   JOURNAL OF ANTIBIOTICS

Visible Fluorescence Detection of Type III Protein Secretion from Bacterial Pathogens

(2010) Jacob S. Yount et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imaging type-III secretion reveals dynamics and spatial segregation of Salmonella effectors

(2010) Schuyler B Van Engelenburg et al.   NATURE METHODS

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Topology and Organization of the Salmonella typhimurium Type III Secretion Needle Complex Components

(2010) Oliver Schraidt et al.   PLoS Pathogens

High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model

(2009) Terence I. Moy et al.   ACS Chemical Biology

Tethered thiazolidinone dimers as inhibitors of the bacterial type III secretion system

(2009) Toni Kline et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells

(2009) Sandra Muschiol et al.   BMC MICROBIOLOGY

Common Themes in the Design and Function of Bacterial Effectors

(2009) Jorge E. Galán   Cell Host & Microbe

Type III secretion systems shape up as they ship out

(2009) Thomas C Marlovits et al.   CURRENT OPINION IN MICROBIOLOGY

Salicylidene acylhydrazide-mediated inhibition of type III secretion system-1 in Salmonella enterica serovar Typhimurium is associated with iron restriction and can be reversed by free iron

(2009) Abigail N. Layton et al.   FEMS MICROBIOLOGY LETTERS

Characterization of the Effects of Salicylidene Acylhydrazide Compounds on Type III Secretion in Escherichia coli O157:H7

(2009) J. J. Tree et al.   INFECTION AND IMMUNITY

Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509

(2009) Masato Iwatsuki et al.   JOURNAL OF ANTIBIOTICS

Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509

(2009) Masato Iwatsuki et al.   JOURNAL OF ANTIBIOTICS

N-Hydroxybenzimidazole Inhibitors of the Transcription Factor LcrF inYersinia: Novel Antivirulence Agents

(2009) Oak K. Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

The type III secretion system of Pseudomonas aeruginosa: infection by injection

(2009) Alan R. Hauser   NATURE REVIEWS MICROBIOLOGY

Clickable fluorescent dyes for multimodal bioorthogonal imaging

(2009) Lun K. Tsou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Targeting Type III Secretion in Yersinia pestis

(2008) N. J. Pan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An Inhibitor of Gram-Negative Bacterial Virulence Protein Secretion

(2008) Heather B. Felise et al.   Cell Host & Microbe

Quantification of Real-Time Salmonella Effector Type III Secretion Kinetics Reveals Differential Secretion Rates for SopE2 and SptP

(2008) Schuyler B. VanEngelenburg et al.   CHEMISTRY & BIOLOGY

Total Synthesis and Determination of the Absolute Configuration of Guadinomines B and C2

(2008) Tomoyasu Hirose et al.   CHEMISTRY-A EUROPEAN JOURNAL

DCDHF Fluorophores for Single-Molecule Imaging in Cells

(2008) Samuel J. Lord et al.   CHEMPHYSCHEM

Small-Molecule Type III Secretion System Inhibitors Block Assembly of the Shigella Type III Secreton

(2008) A. K. J. Veenendaal et al.   JOURNAL OF BACTERIOLOGY

Virulence blockers as alternatives to antibiotics: type III secretion inhibitors against Gram-negative bacteria

(2008) P. Keyser et al.   JOURNAL OF INTERNAL MEDICINE

Substituted 2-Imino-5-arylidenethiazolidin-4-one Inhibitors of Bacterial Type III Secretion

(2008) Toni Kline et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Photoactivatable Push−Pull Fluorophore for Single-Molecule Imaging in Live Cells

(2008) Samuel J. Lord et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY