cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases

Crosstalk between Phosphodiesterase 7 and Glycogen Synthase Kinase-3: Two Relevant Therapeutic Targets for Neurological Disorders

(2014) Jose A. Morales-Garcia et al.   ACS Chemical Neuroscience

Lack of Efficacy of an Inhibitor of PDE4 in Phase 1 and 2 Trials of Patients With Nonalcoholic Steatohepatitis

(2014) Vlad Ratziu et al.   Clinical Gastroenterology and Hepatology

Apremilast: First Global Approval

(2014) Raewyn M. Poole et al.   DRUGS

PDE inhibitors currently in early clinical trials for the treatment of asthma

(2014) Maria Gabriella Matera et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Novel Class of Benzoic Acid Ester Derivatives as Potent PDE4 Inhibitors for Inhaled Administration in the Treatment of Respiratory Diseases

(2014) Elisabetta Armani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Advances in targeting cyclic nucleotide phosphodiesterases

(2014) Donald H. Maurice et al.   NATURE REVIEWS DRUG DISCOVERY

Apremilast for the treatment of psoriatic arthritis

(2014) Sowmya Varada et al.   Expert Review of Clinical Pharmacology

Synthesis and evaluation of quinazoline derivatives as phosphodiesterase 7 inhibitors

(2013) Ana I. Sánchez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phosphodiesterase 4-targeted treatments for autoimmune diseases

(2013) Neal Kumar et al.   BMC Medicine

Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis

(2013) C González-García et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival

(2013) E. M. Medina-Rodríguez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Select 3′,5′-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain

(2013) Michy P. Kelly et al.   CELLULAR SIGNALLING

Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities

(2013) Miriam Redondo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders

(2013) Maliheh Safavi et al.   Expert Opinion on Drug Discovery

Phosphodiesterase-4 inhibitors: a review of current developments (2010 – 2012)

(2013) Amadeu Gavaldà et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

PDE4 as a target for cognition enhancement

(2013) Wito Richter et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Novel systemic drugs for psoriasis: Mechanism of action for apremilast, a specific inhibitor of PDE4

(2013) Peter H. Schafer et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

PDE4 inhibitor leads wave of target-specific oral psoriasis drugs

(2013) Charlotte Harrison   NATURE REVIEWS DRUG DISCOVERY

Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

(2013) Rocio Perez-Gonzalez et al.   NEUROBIOLOGY OF AGING

A Yeast-Based Chemical Screen Identifies a PDE Inhibitor That Elevates Steroidogenesis in Mouse Leydig Cells via PDE8 and PDE4 Inhibition

(2013) Didem Demirbas et al.   PLoS One

Safety and tolerability of the inhaled phosphodiesterase 4 inhibitor GSK256066 in moderate COPD

(2013) Henrik Watz et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease

(2012) Ana García-Osta et al.   ACS Chemical Neuroscience

Identification in Silico and Experimental Validation of Novel Phosphodiesterase 7 Inhibitors with Efficacy in Experimental Autoimmune Encephalomyelitis Mice

(2012) Miriam Redondo et al.   ACS Chemical Neuroscience

Discovery of triazolopyrimidine-based PDE8B inhibitors: Exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes

(2012) Michael P. DeNinno et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson’s disease model

(2012) Abhisek Banerjee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Roflumilast: A Phosphodiesterase-4 Inhibitor for the Treatment of Severe Chronic Obstructive Pulmonary Disease

(2012) Nathan A. Pinner et al.   CLINICAL THERAPEUTICS

Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center

(2012) Yvonne R. Freund et al.   FEBS LETTERS

Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay

(2012) L.-C. L. Tsai et al.   GENES BRAIN AND BEHAVIOR

Regulation of Adrenal Steroidogenesis by the High-affinity Phosphodiesterase 8 Family

(2012) L-C. Tsai et al.   HORMONE AND METABOLIC RESEARCH

Effect of Phosphodiesterase 7 (PDE7) Inhibitors in Experimental Autoimmune Encephalomyelitis Mice. Discovery of a New Chemically Diverse Family of Compounds

(2012) Miriam Redondo et al.   JOURNAL OF MEDICINAL CHEMISTRY

The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury

(2012) Cristina Susín et al.   JOURNAL OF NEUROCHEMISTRY

Comparison of cAMP-specific phosphodiesterase mRNAs distribution in mouse and rat brain

(2012) Emily M. Johansson et al.   NEUROSCIENCE LETTERS

1,5-Substituted nipecotic amides: Selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability

(2011) Michael P. DeNinno et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses

(2011) O Bruno et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions

(2011) Sharron H. Francis et al.   PHYSIOLOGICAL REVIEWS

PDE 7 Inhibitors: New Potential Drugs for the Therapy of Spinal Cord Injury

(2011) Irene Paterniti et al.   PLoS One

Phosphodiesterase 7 Inhibition Preserves Dopaminergic Neurons in Cellular and Rodent Models of Parkinson Disease

(2011) Jose A. Morales-Garcia et al.   PLoS One

Autosomal-Dominant Striatal Degeneration Is Caused by a Mutation in the Phosphodiesterase 8B Gene

(2010) Silke Appenzeller et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment

(2010) Michel Gallant et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

(2010) F. Mori et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Phosphodiesterase 8A (PDE8A) regulates excitation–contraction coupling in ventricular myocytes

(2010) Enrico Patrucco et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The High-Affinity cAMP-Specific Phosphodiesterase 8B Controls Steroidogenesis in the Mouse Adrenal Gland

(2010) L.-C. L. Tsai et al.   MOLECULAR PHARMACOLOGY

Overall Synthesis of GSK356278: Quick Delivery of a PDE4 Inhibitor Using a Fit-for-Purpose Approach

(2010) Giuseppe Guercio et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

PDE8 Regulates Rapid Teff Cell Adhesion and Proliferation Independent of ICER

(2010) Amanda G. Vang et al.   PLoS One

Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation

(2009) Junqing Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

(2009) Tania Castaño et al.   ChemMedChem

PDE4 inhibitors: a review of current developments (2005 – 2009)

(2009) Lluís Pagès et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Differentiation of mouse Neuro 2A cells into dopamine neurons

(2009) Roger G. Tremblay et al.   JOURNAL OF NEUROSCIENCE METHODS

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity†‡

(2008) Huanchen Wang et al.   BIOCHEMISTRY

A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex

(2008) Anelia Horvath et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

PDE7 inhibitors as new drugs for neurological and inflammatory disorders

(2008) Carmen Gil et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

(2008) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advantageous toxicity profile of inhaled antisense oligonucleotides following chronic dosing in non-human primates

(2008) Alain Guimond et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example

(2007) Ana Castro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY